Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0012973
UniProt IDP04628
Primary gene name(s)WNT1
Synonym gene name(s)INT1
Protein nameProto-oncogene Wnt-1
Protein functionLigand for members of the frizzled family of seven transmembrane receptors. In some developmental processes, is also a ligand for the coreceptor RYK, thus triggering Wnt signaling. Probable developmental protein. May be a signaling molecule important in CNS development. Is likely to signal over only few cell diameters. Has a role in osteoblast function and bone development. {ECO:0000269|PubMed:23499309}.
Subcellular locationSecreted, extracellular space, extracellular matrix.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P04628
Gene Ontology
(Biological Process)
Complete annatation
animal organ regeneration [GO:0031100];
astrocyte-dopaminergic neuron signaling [GO:0036520];
beta-catenin destruction complex disassembly [GO:1904886];
bone development [GO:0060348];
branching involved in ureteric bud morphogenesis [GO:0001658];
canonical Wnt signaling pathway [GO:0060070];
canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation [GO:1904954];
canonical Wnt signaling pathway involved in negative regulation of apoptotic process [GO:0044336];
cell-cell signaling [GO:0007267];
cell fate commitment [GO:0045165];
cell proliferation in midbrain [GO:0033278];
cellular response to peptide hormone stimulus [GO:0071375];
central nervous system morphogenesis [GO:0021551];
cerebellum formation [GO:0021588];
diencephalon development [GO:0021536];
embryonic axis specification [GO:0000578];
embryonic brain development [GO:1990403];
forebrain anterior/posterior pattern specification [GO:0021797];
hematopoietic stem cell proliferation [GO:0071425];
hepatocyte differentiation [GO:0070365];
inner ear morphogenesis [GO:0042472];
midbrain development [GO:0030901];
midbrain-hindbrain boundary maturation during brain development [GO:0022004];
myoblast fusion [GO:0007520];
negative regulation of BMP signaling pathway [GO:0030514];
negative regulation of cell aging [GO:0090344];
negative regulation of cell-cell adhesion [GO:0022408];
negative regulation of cell-substrate adhesion [GO:0010812];
negative regulation of fat cell differentiation [GO:0045599];
negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:2000059];
negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512];
neuron fate determination [GO:0048664];
positive regulation of canonical Wnt signaling pathway [GO:0090263];
positive regulation of cell proliferation [GO:0008284];
positive regulation of dermatome development [GO:0061184];
positive regulation of fibroblast proliferation [GO:0048146];
positive regulation of insulin-like growth factor receptor signaling pathway [GO:0043568];
positive regulation of lamellipodium assembly [GO:0010592];
positive regulation of Notch signaling pathway [GO:0045747];
positive regulation of protein phosphorylation [GO:0001934];
positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091];
positive regulation of transcription, DNA-templated [GO:0045893];
positive regulation of transcription from RNA polymerase II promoter [GO:0045944];
response to wounding [GO:0009611];
signal transduction in response to DNA damage [GO:0042770];
Spemann organizer formation [GO:0060061];
spinal cord association neuron differentiation [GO:0021527];
T cell differentiation in thymus [GO:0033077];
ubiquitin-dependent SMAD protein catabolic process [GO:0030579];
Wnt signaling pathway [GO:0016055];
Wnt signaling pathway, planar cell polarity pathway [GO:0060071];
Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation [GO:1904953]
Gene Ontology
(Molecular Function)
Complete annatation
cytokine activity [GO:0005125];
frizzled binding [GO:0005109];
morphogen activity [GO:0016015];
receptor agonist activity [GO:0048018];
transcription regulatory region DNA binding [GO:0044212]
Gene Ontology
(Cellular Component)
Complete annatation
cell surface [GO:0009986];
cytoplasm [GO:0005737];
endocytic vesicle membrane [GO:0030666];
endoplasmic reticulum lumen [GO:0005788];
extracellular exosome [GO:0070062];
extracellular region [GO:0005576];
extracellular space [GO:0005615];
Golgi lumen [GO:0005796];
plasma membrane [GO:0005886];
proteinaceous extracellular matrix [GO:0005578]
Protein-protein interaction113308
Phylogenetic treeP04628
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3unknownunknownunknown
AZA vs. DISU-0.3092845704156220.3085674524172260.866242136589333
AZA vs. IL7-0.5830362721887290.02572616593138530.51224636602876
AZA vs. SAHA0.8770294411690820.005884504950581790.0688153821761598
DISU vs. CD3unknownunknownunknown
DISU vs. IL7-0.2927642716784790.3384128755178480.718835296383199
DISU vs. SAHA1.179110500433270.001370751816814790.0257588536548823
DMSO vs. AZA0.1979812757987760.3888167614978421
DMSO vs. CD33.770209074784240.005932703260212780.0158820759495045
DMSO vs. DISU0.5040876924999430.08006837030886130.528263158368072
DMSO vs. IL7-0.7729545729529140.001427641884701790.071739004706265
DMSO vs. SAHA0.6693027354935580.03939093874971020.220118961029619
HIV vs. Mock in Activationunknownunknownunknown
HIV vs. Mock in Latency-0.6589170547279980.09540233403553220.999834320637052
IL7 vs. CD3unknownunknownunknown
SAHA vs. CD34.419543620723970.003100945649842980.00945976739739548
SAHA vs. IL71.453590008651143.95156137418251e-050.000924935344012844
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) unknown
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -1.63626 0.000305467
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Tat downregulates 23152614
HIV-1 virus replication enhanced by expression of human gene 18187620

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04150 mTOR signaling pathway - Homo sapiens (human)
hsa04310 Wnt signaling pathway - Homo sapiens (human)
hsa04390 Hippo signaling pathway - Homo sapiens (human)
hsa04550 Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)
hsa04916 Melanogenesis - Homo sapiens (human)
hsa05166 HTLV-I infection - Homo sapiens (human)
hsa05200 Pathways in cancer - Homo sapiens (human)
hsa05205 Proteoglycans in cancer - Homo sapiens (human)
hsa05217 Basal cell carcinoma - Homo sapiens (human)
hsa05224 Breast cancer - Homo sapiens (human)