Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0012233
UniProt IDP28068
Primary gene name(s)HLA-DMB
Synonym gene name(s)DMB, RING7
Protein nameHLA class II histocompatibility antigen, DM beta chain
Protein functionPlays a critical role in catalyzing the release of class II-associated invariant chain peptide, CLIP from newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. {ECO:0000269|PubMed:16547258, ECO:0000269|PubMed:8849454, ECO:0000269|PubMed:9768757}.
Subcellular locationLate endosome membrane {ECO:0000269|PubMed:8757605};
Single-pass type I membrane protein {ECO:0000269|PubMed:8757605}. Lysosome membrane {ECO:0000269|PubMed:8757605};
Single-pass type I membrane protein {ECO:0000269|PubMed:8757605}. Note=Localizes to late endocytic compartment. Associates with lysosome membranes.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P28068
Gene Ontology
(Biological Process)
Complete annatation
antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886];
immune response [GO:0006955];
MHC class II protein complex assembly [GO:0002399];
peptide antigen assembly with MHC class II protein complex [GO:0002503];
positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell [GO:2001190];
positive regulation of T cell proliferation [GO:0042102]
Gene Ontology
(Molecular Function)
Complete annatation
MHC class II protein complex binding [GO:0023026]
Gene Ontology
(Cellular Component)
Complete annatation
integral component of membrane [GO:0016021];
late endosome membrane [GO:0031902];
lysosomal membrane [GO:0005765];
MHC class II protein complex [GO:0042613]
Protein-protein interaction109354
Phylogenetic treeP28068
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-1.866096007243559.52655789809853e-089.23371579679364e-07
AZA vs. DISU-0.7189404897508620.006216117950425650.202887995963702
AZA vs. IL7-0.1144389131820080.5717975067291830.999311006273513
AZA vs. SAHA1.672922349504515.29201127363876e-112.09925731417976e-08
DISU vs. CD31.137262746030170.002694868908405760.00966740931111575
DISU vs. IL70.5947031379991410.02321871709933390.193596327584324
DISU vs. SAHA2.392981959112691.19904086659517e-149.51091836866094e-12
DMSO vs. AZA0.06758219913669340.7048547484573881
DMSO vs. CD31.919187730050051.93657451186269e-081.94886406287317e-07
DMSO vs. DISU0.7840732123762810.001971230714273850.0928326464503343
DMSO vs. IL7-0.1748244439828990.356134522454730.820892812748705
DMSO vs. SAHA1.60023703529837.15033587894709e-112.04329802030005e-08
HIV vs. Mock in Activation-0.6694325015124380.3041773060713230.999983755607037
HIV vs. Mock in Latency-0.1539662853132760.3679913229302630.999834320637052
IL7 vs. CD31.757688514088223.6357493171657e-073.89565576028575e-06
SAHA vs. CD33.5165251439955700
SAHA vs. IL71.785357251320323.60977914226623e-129.06896846508687e-10
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) unknown
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.666138 0.000305467
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
1HDM X-ray 2.5Å B=19-218.
2BC4 X-ray 2.2Å B/D=19-256.
4FQX X-ray 2.6Å D=19-211.
4GBX X-ray 3.0Å D=19-211.
4I0P X-ray 3.2Å B/F=21-211.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Pr55(Gag) upregulates 18945465
Envelope transmembrane glycoprotein gp41 incorporates 10729169
Envelope surface glycoprotein gp120 interacts with 1869305
Envelope surface glycoprotein gp160; precursor associates with 3489470
Nef inhibits 11593029
Nef downregulates 12970439
Pr55(Gag) regulated by 22860026
Tat downregulates 10661406
Vpu modulates 17959659
Envelope transmembrane glycoprotein gp41 upregulates 8084338
Envelope surface glycoprotein gp120 inhibits 2543930

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04145 Phagosome - Homo sapiens (human)
hsa04514 Cell adhesion molecules (CAMs) - Homo sapiens (human)
hsa04612 Antigen processing and presentation - Homo sapiens (human)
hsa04640 Hematopoietic cell lineage - Homo sapiens (human)
hsa04658 Th1 and Th2 cell differentiation - Homo sapiens (human)
hsa04659 Th17 cell differentiation - Homo sapiens (human)
hsa04672 Intestinal immune network for IgA production - Homo sapiens (human)
hsa04940 Type I diabetes mellitus - Homo sapiens (human)
hsa05140 Leishmaniasis - Homo sapiens (human)
hsa05145 Toxoplasmosis - Homo sapiens (human)
hsa05150 Staphylococcus aureus infection - Homo sapiens (human)
hsa05152 Tuberculosis - Homo sapiens (human)
hsa05164 Influenza A - Homo sapiens (human)
hsa05166 HTLV-I infection - Homo sapiens (human)
hsa05168 Herpes simplex infection - Homo sapiens (human)
hsa05310 Asthma - Homo sapiens (human)
hsa05320 Autoimmune thyroid disease - Homo sapiens (human)
hsa05321 Inflammatory bowel disease (IBD) - Homo sapiens (human)
hsa05322 Systemic lupus erythematosus - Homo sapiens (human)
hsa05323 Rheumatoid arthritis - Homo sapiens (human)
hsa05330 Allograft rejection - Homo sapiens (human)
hsa05332 Graft-versus-host disease - Homo sapiens (human)
hsa05416 Viral myocarditis - Homo sapiens (human)