Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0011945
UniProt IDP16234
Primary gene name(s)PDGFRA
Synonym gene name(s)PDGFR2, RHEPDGFRA
Protein namePlatelet-derived growth factor receptor alpha
Protein functionTyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development and cephalic closure during embryonic development. Required for normal development of the mucosa lining the gastrointestinal tract, and for recruitment of mesenchymal cells and normal development of intestinal villi. Plays a role in cell migration and chemotaxis in wound healing. Plays a role in platelet activation, secretion of agonists from platelet granules, and in thrombin-induced platelet aggregation. Binding of its cognate ligands - homodimeric PDGFA, homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFC -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PIK3R1, PLCG1, and PTPN11. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca(2+ and the activation of protein kinase C. Phosphorylates PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and thereby mediates activation of the AKT1 signaling pathway. Mediates activation of HRAS and of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3 and STAT5A and/or STAT5B. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor. {ECO:0000269|PubMed:10734113, ECO:0000269|PubMed:10947961, ECO:0000269|PubMed:11297552, ECO:0000269|PubMed:12522257, ECO:0000269|PubMed:1646396, ECO:0000269|PubMed:1709159, ECO:0000269|PubMed:17141222, ECO:0000269|PubMed:20972453, ECO:0000269|PubMed:21224473, ECO:0000269|PubMed:21596750, ECO:0000269|PubMed:2554309, ECO:0000269|PubMed:8188664, ECO:0000269|PubMed:8760137, ECO:0000269|PubMed:8943348}.
Subcellular locationCell membrane {ECO:0000269|PubMed:14644164, ECO:0000269|PubMed:2554309, ECO:0000269|PubMed:8188664};
Single-pass type I membrane protein {ECO:0000269|PubMed:14644164, ECO:0000269|PubMed:2554309, ECO:0000269|PubMed:8188664}. Note=The activated receptor is rapidly internalized and degraded.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P16234
Gene Ontology
(Biological Process)
Complete annatation
cardiac myofibril assembly [GO:0055003];
cell activation [GO:0001775];
cell chemotaxis [GO:0060326];
cellular response to reactive oxygen species [GO:0034614];
embryonic cranial skeleton morphogenesis [GO:0048701];
embryonic digestive tract morphogenesis [GO:0048557];
embryonic skeletal system morphogenesis [GO:0048704];
luteinization [GO:0001553];
MAPK cascade [GO:0000165];
metanephric glomerular capillary formation [GO:0072277];
negative regulation of platelet activation [GO:0010544];
peptidyl-tyrosine phosphorylation [GO:0018108];
phosphatidylinositol-mediated signaling [GO:0048015];
platelet aggregation [GO:0070527];
platelet-derived growth factor receptor-alpha signaling pathway [GO:0035790];
platelet-derived growth factor receptor signaling pathway [GO:0048008];
positive regulation of cell migration [GO:0030335];
positive regulation of cell proliferation [GO:0008284];
positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway [GO:0038091];
positive regulation of cytosolic calcium ion concentration [GO:0007204];
positive regulation of DNA replication [GO:0045740];
positive regulation of ERK1 and ERK2 cascade [GO:0070374];
positive regulation of fibroblast proliferation [GO:0048146];
positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552];
positive regulation of phosphatidylinositol 3-kinase signaling [GO:0014068];
positive regulation of phospholipase C activity [GO:0010863];
protein autophosphorylation [GO:0046777];
regulation of actin cytoskeleton reorganization [GO:2000249];
regulation of chemotaxis [GO:0050920];
regulation of mesenchymal stem cell differentiation [GO:2000739];
regulation of phosphatidylinositol 3-kinase signaling [GO:0014066];
retina vasculature development in camera-type eye [GO:0061298];
viral process [GO:0016032];
wound healing [GO:0042060]
Gene Ontology
(Molecular Function)
Complete annatation
ATP binding [GO:0005524];
phosphatidylinositol-4,5-bisphosphate 3-kinase activity [GO:0046934];
platelet-derived growth factor alpha-receptor activity [GO:0005018];
platelet-derived growth factor binding [GO:0048407];
platelet-derived growth factor receptor binding [GO:0005161];
protein homodimerization activity [GO:0042803];
protein kinase activity [GO:0004672];
Ras guanyl-nucleotide exchange factor activity [GO:0005088];
transmembrane receptor protein tyrosine kinase activity [GO:0004714];
vascular endothelial growth factor-activated receptor activity [GO:0005021];
vascular endothelial growth factor binding [GO:0038085]
Gene Ontology
(Cellular Component)
Complete annatation
cytoplasm [GO:0005737];
integral component of plasma membrane [GO:0005887];
intrinsic component of plasma membrane [GO:0031226];
membrane [GO:0016020];
nucleus [GO:0005634];
plasma membrane [GO:0005886];
protein complex [GO:0043234]
Protein-protein interaction111182
Phylogenetic treeP16234
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-0.8790615141161370.08434735073955010.153148207486628
AZA vs. DISU-0.3719628032262480.5538247605251460.947615666465684
AZA vs. IL7-0.4622110647094950.3191971690012740.999311006273513
AZA vs. SAHA1.027385001236310.02567079179578880.180992289770683
DISU vs. CD3unknownunknownunknown
DISU vs. IL7-0.09166125174169170.8877906482968170.979940654995064
DISU vs. SAHA1.403261589794980.03062936891774590.209634522688169
DMSO vs. AZA0.02339472493449890.9708318195083451
DMSO vs. CD3unknownunknownunknown
DMSO vs. DISU0.3883191779360870.6167345580633440.939959716278526
DMSO vs. IL7-0.4731477680688980.4656670917444110.876252870495513
DMSO vs. SAHA1.005219637502370.1175448790458680.407996055297161
HIV vs. Mock in Activationunknownunknownunknown
HIV vs. Mock in Latency-0.5912290914659740.3319147882443330.999834320637052
IL7 vs. CD3unknownunknownunknown
SAHA vs. CD31.877878834765020.0003160610294938860.00131493118157652
SAHA vs. IL71.484845565891080.001771465595972850.0180670313895093
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) unknown
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -0.00193252 0.994936
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

Drugbank ID Drug Name Drug Status Pharmacological Action Drug Action
DB01268 Sunitinib approved, investigational yes inhibitor
DB00619 Imatinib approved unknown antagonist
DB00102 Becaplermin approved, investigational unknown unknown
DB05216 MP470 investigational unknown unknown
DB05146 XL820 investigational unknown unknown
DB06043 Olaratumab investigational yes unknown
DB06589 Pazopanib approved yes inhibitor
DB08896 Regorafenib approved yes inhibitor
DB08901 Ponatinib approved unknown inhibitor

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
1GQ5 X-ray 2.2Å -.
5K5X X-ray 2.1Å A=550-973.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa01521 EGFR tyrosine kinase inhibitor resistance - Homo sapiens (human)
hsa04010 MAPK signaling pathway - Homo sapiens (human)
hsa04014 Ras signaling pathway - Homo sapiens (human)
hsa04015 Rap1 signaling pathway - Homo sapiens (human)
hsa04020 Calcium signaling pathway - Homo sapiens (human)
hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human)
hsa04072 Phospholipase D signaling pathway - Homo sapiens (human)
hsa04144 Endocytosis - Homo sapiens (human)
hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
hsa04510 Focal adhesion - Homo sapiens (human)
hsa04540 Gap junction - Homo sapiens (human)
hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human)
hsa05166 HTLV-I infection - Homo sapiens (human)
hsa05200 Pathways in cancer - Homo sapiens (human)
hsa05206 MicroRNAs in cancer - Homo sapiens (human)
hsa05214 Glioma - Homo sapiens (human)
hsa05215 Prostate cancer - Homo sapiens (human)
hsa05218 Melanoma - Homo sapiens (human)
hsa05230 Central carbon metabolism in cancer - Homo sapiens (human)
hsa05231 Choline metabolism in cancer - Homo sapiens (human)