Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0011712
UniProt IDO00755
Primary gene name(s)WNT7A
Synonym gene name(s)unknown
Protein nameProtein Wnt-7a
Protein functionLigand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. Signaling by Wnt-7a allows sexually dimorphic development of the mullerian ducts, By similarity. {ECO:0000250}.
Subcellular locationSecreted, extracellular space, extracellular matrix.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: O00755
Gene Ontology
(Biological Process)
Complete annatation
angiogenesis [GO:0001525];
asymmetric protein localization [GO:0008105];
axonogenesis [GO:0007409];
canonical Wnt signaling pathway [GO:0060070];
cartilage condensation [GO:0001502];
cell fate commitment [GO:0045165];
cell proliferation in forebrain [GO:0021846];
cellular response to transforming growth factor beta stimulus [GO:0071560];
central nervous system vasculogenesis [GO:0022009];
cerebellar granule cell differentiation [GO:0021707];
chondrocyte differentiation [GO:0002062];
dendritic spine morphogenesis [GO:0060997];
dorsal/ventral pattern formation [GO:0009953];
embryonic axis specification [GO:0000578];
embryonic digit morphogenesis [GO:0042733];
embryonic forelimb morphogenesis [GO:0035115];
embryonic hindlimb morphogenesis [GO:0035116];
establishment of cell polarity [GO:0030010];
excitatory synapse assembly [GO:1904861];
lens fiber cell development [GO:0070307];
negative regulation of apoptotic process [GO:0043066];
negative regulation of neurogenesis [GO:0050768];
neurotransmitter secretion [GO:0007269];
non-canonical Wnt signaling pathway [GO:0035567];
oviduct development [GO:0060066];
palate development [GO:0060021];
positive regulation of canonical Wnt signaling pathway [GO:0090263];
positive regulation of endothelial cell migration [GO:0010595];
positive regulation of epithelial cell proliferation involved in wound healing [GO:0060054];
positive regulation of excitatory postsynaptic potential [GO:2000463];
positive regulation of excitatory synapse assembly [GO:1904891];
positive regulation of JNK cascade [GO:0046330];
positive regulation of protein localization to presynapse [GO:1905386];
positive regulation of synapse assembly [GO:0051965];
positive regulation of transcription, DNA-templated [GO:0045893];
positive regulation of transcription from RNA polymerase II promoter [GO:0045944];
postsynapse assembly [GO:0099068];
presynapse assembly [GO:0099054];
regulation of axon diameter [GO:0031133];
response to estradiol [GO:0032355];
response to estrogen [GO:0043627];
sex differentiation [GO:0007548];
skeletal muscle satellite cell activation [GO:0014719];
skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration [GO:0014834];
somatic stem cell division [GO:0048103];
somatic stem cell population maintenance [GO:0035019];
stem cell development [GO:0048864];
synaptic vesicle recycling [GO:0036465];
uterus morphogenesis [GO:0061038];
Wnt signaling pathway [GO:0016055];
Wnt signaling pathway involved in wound healing, spreading of epidermal cells [GO:0035659]
Gene Ontology
(Molecular Function)
Complete annatation
cytokine activity [GO:0005125];
frizzled binding [GO:0005109];
receptor agonist activity [GO:0048018];
receptor binding [GO:0005102]
Gene Ontology
(Cellular Component)
Complete annatation
cell surface [GO:0009986];
cytosol [GO:0005829];
endocytic vesicle membrane [GO:0030666];
endoplasmic reticulum lumen [GO:0005788];
extracellular exosome [GO:0070062];
extracellular region [GO:0005576];
extracellular space [GO:0005615];
Golgi lumen [GO:0005796];
plasma membrane [GO:0005886];
presynapse [GO:0098793];
proteinaceous extracellular matrix [GO:0005578]
Protein-protein interaction113313
Phylogenetic treeO00755
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-4.3805481599433400
AZA vs. DISU-0.899200027061880.001643799553684770.103676294862946
AZA vs. IL7-0.6966407296632120.006988300535672560.27125551542422
AZA vs. SAHA-0.4597108998053510.09605044360841930.391632238829676
DISU vs. CD3unknownunknownunknown
DISU vs. IL70.193759769100880.5042358025984270.829208544144354
DISU vs. SAHA0.4390249490090430.1764508133268720.540607837535191
DMSO vs. AZA-0.05814968376913780.8570814997532911
DMSO vs. CD34.3033735242230300
DMSO vs. DISU0.835872106331520.005038643868916170.15285309757736
DMSO vs. IL7-0.6278325060554670.0384163184068370.402405979557844
DMSO vs. SAHA-0.4066315748777890.1545105131557740.474226761959934
HIV vs. Mock in Activationunknownunknownunknown
HIV vs. Mock in Latency-0.4533715695777550.2474068705057020.999834320637052
IL7 vs. CD33.7076416270512400
SAHA vs. CD33.9069114312735400
SAHA vs. IL70.2268677301054410.4184595916209870.6621729880427
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) unknown
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -1.90826 0.00241278
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
-0.04 0.003

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
4UZQ X-ray 1.5Å B=202-209.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04150 mTOR signaling pathway - Homo sapiens (human)
hsa04310 Wnt signaling pathway - Homo sapiens (human)
hsa04390 Hippo signaling pathway - Homo sapiens (human)
hsa04550 Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)
hsa04916 Melanogenesis - Homo sapiens (human)
hsa05166 HTLV-I infection - Homo sapiens (human)
hsa05200 Pathways in cancer - Homo sapiens (human)
hsa05205 Proteoglycans in cancer - Homo sapiens (human)
hsa05217 Basal cell carcinoma - Homo sapiens (human)
hsa05224 Breast cancer - Homo sapiens (human)