Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0011557
UniProt IDQ9UBR2
Primary gene name(s)CTSZ
Synonym gene name(s)unknown
Protein nameCathepsin Z
Protein functionExhibits carboxy-monopeptidase as well as carboxy-dipeptidase activity.
Subcellular locationLysosome.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q9UBR2
Gene Ontology
(Biological Process)
Complete annatation
angiotensin maturation [GO:0002003];
COPII vesicle coating [GO:0048208];
epithelial tube branching involved in lung morphogenesis [GO:0060441];
ER to Golgi vesicle-mediated transport [GO:0006888];
proteolysis [GO:0006508];
proteolysis involved in cellular protein catabolic process [GO:0051603]
Gene Ontology
(Molecular Function)
Complete annatation
cysteine-type endopeptidase activity [GO:0004197];
cysteine-type peptidase activity [GO:0008234]
Gene Ontology
(Cellular Component)
Complete annatation
endoplasmic reticulum [GO:0005783];
endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116];
endoplasmic reticulum lumen [GO:0005788];
ER to Golgi transport vesicle [GO:0030134];
extracellular exosome [GO:0070062];
extracellular space [GO:0005615];
Golgi membrane [GO:0000139];
intracellular membrane-bounded organelle [GO:0043231];
lysosome [GO:0005764];
plasma membrane [GO:0005886]
Protein-protein interaction107902
Phylogenetic treeQ9UBR2
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
      Yes - Two siRNA pools inhibit HIV replication and inhibition of Tat-mediated transactivation of the HIV LTR is not observed
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-0.2883696134269730.3869913546770330.508653849977521
AZA vs. DISU-0.210470303010110.406849361831630.906679176201363
AZA vs. IL70.00706806047408120.9708329310994320.999311006273513
AZA vs. SAHA0.1028390208425170.6743768711277790.9044342258228
DISU vs. CD30.06675892280279460.8566056129103320.903045229668969
DISU vs. IL70.2077053011396870.4112106846377540.770145655542703
DISU vs. SAHA0.3153798657815920.280257601273280.661202615652723
DMSO vs. AZA0.02573274654365410.8788259060986261
DMSO vs. CD30.3036928166086440.3509716568363590.465316202608443
DMSO vs. DISU0.2345385074029770.3378959977755850.837145111953607
DMSO vs. IL7-0.01149637185958030.949304944982040.990836487125109
DMSO vs. SAHA0.07112989156200790.76354959359390.931825079317738
HIV vs. Mock in Activation0.03077850503053310.9629184098798760.999983755607037
HIV vs. Mock in Latency-0.03601097722419240.828321228558810.999834320637052
IL7 vs. CD30.3016114769829940.3543761933423880.491489911874293
SAHA vs. CD30.3674420156346130.3101804124059840.423868227689352
SAHA vs. IL70.09334474039518720.7026387544647060.862436005602229
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) unknown
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.365457 0.00438837
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
1DEU X-ray 1.7Å A/B=27-303.
1EF7 X-ray 2.6Å A/B=62-303.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Vpr upregulates 23874603
Tat upregulates 22632162
HIV-1 virus replication enhanced by expression of human gene 18976975

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04142 Lysosome - Homo sapiens (human)
hsa04210 Apoptosis - Homo sapiens (human)