Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0011445
UniProt IDP25024
Primary gene name(s)CXCR1
Synonym gene name(s)CMKAR1, IL8RA
Protein nameC-X-C chemokine receptor type 1
Protein functionReceptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA, GRO with a low affinity.
Subcellular locationCell membrane;
Multi-pass membrane protein.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P25024
Gene Ontology
(Biological Process)
Complete annatation
cell surface receptor signaling pathway [GO:0007166];
chemotaxis [GO:0006935];
dendritic cell chemotaxis [GO:0002407];
G-protein coupled receptor signaling pathway [GO:0007186];
inflammatory response [GO:0006954];
receptor internalization [GO:0031623]
Gene Ontology
(Molecular Function)
Complete annatation
chemokine receptor activity [GO:0004950];
G-protein coupled receptor activity [GO:0004930];
interleukin-8 binding [GO:0019959];
interleukin-8 receptor activity [GO:0004918]
Gene Ontology
(Cellular Component)
Complete annatation
integral component of membrane [GO:0016021];
membrane [GO:0016020];
plasma membrane [GO:0005886]
Protein-protein interaction109791
Phylogenetic treeP25024
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-8.9783174765703600
AZA vs. DISU-0.6495315531595990.2304519834736110.817595829287508
AZA vs. IL70.3004698117213430.1631053396438440.930759564799561
AZA vs. SAHA-0.2148185472976920.6161382247825180.875360859609696
DISU vs. CD38.643028652592032.42028619368284e-141.14010606511172e-12
DISU vs. IL70.9372469285792190.08390985360724710.383633160404773
DISU vs. SAHA0.4338281860111630.5498573303123060.851231151414605
DMSO vs. AZA0.1383010869502350.4802091977455181
DMSO vs. CD39.1036705275545900
DMSO vs. DISU0.783969523667030.1406428130102820.633424573410949
DMSO vs. IL70.1694356355458380.3993179204456750.844991247995305
DMSO vs. SAHA-0.3572420204555930.3932950291936390.738150608340889
HIV vs. Mock in Activationunknownunknownunknown
HIV vs. Mock in Latency0.2393768759313390.1899193736141680.999834320637052
IL7 vs. CD39.2763237616632800
SAHA vs. CD38.7401386903990100
SAHA vs. IL7-0.5161385539678510.2157321230784310.453802124376816
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) unknown
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.764978 0.0234913
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

Drugbank ID Drug Name Drug Status Pharmacological Action Drug Action
DB01009 Ketoprofen approved, vet_approved unknown other

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
1ILP NMR - C=9-29.
1ILQ NMR - C=9-29.
2LNL NMR - A=20-328.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
matrix interacts with 22262769
matrix binds 22904195
Nef downregulates 24489825
capsid enhanced by 24662979

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human)
hsa04062 Chemokine signaling pathway - Homo sapiens (human)
hsa04072 Phospholipase D signaling pathway - Homo sapiens (human)
hsa04144 Endocytosis - Homo sapiens (human)
hsa05120 Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human)