Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0011169
UniProt IDP10301
Primary gene name(s)RRAS
Synonym gene name(s)unknown
Protein nameRas-related protein R-Ras
Protein functionRegulates the organization of the actin cytoskeleton, PubMed:16537651, PubMed:18270267. With OSPBL3, modulates integrin beta-1, ITGB1 activity, PubMed:18270267. {ECO:0000269|PubMed:16537651, ECO:0000269|PubMed:18270267}.
Subcellular locationCell membrane {ECO:0000250};
Lipid-anchor {ECO:0000250};
Cytoplasmic side {ECO:0000250}. Note=Inner surface of plasma membrane possibly with attachment requiring acylation of the C-terminal cysteine, By similarity with RAS.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P10301
Gene Ontology
(Biological Process)
Complete annatation
face morphogenesis [GO:0060325];
leukocyte differentiation [GO:0002521];
negative regulation of cell migration [GO:0030336];
positive regulation of angiogenesis [GO:0045766];
Ras protein signal transduction [GO:0007265];
regulation of ERK1 and ERK2 cascade [GO:0070372];
regulation of protein kinase B signaling [GO:0051896]
Gene Ontology
(Molecular Function)
Complete annatation
GDP binding [GO:0019003];
GTPase activity [GO:0003924];
GTP binding [GO:0005525];
protein complex binding [GO:0032403]
Gene Ontology
(Cellular Component)
Complete annatation
extracellular exosome [GO:0070062];
focal adhesion [GO:0005925];
intracellular [GO:0005622];
plasma membrane [GO:0005886]
Protein-protein interaction112151
Phylogenetic treeP10301
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
      unknown
Brass et al., Science, 2008
      unknown
Smith et al., J. Immunol, 2010
      unknown
Interferon-stimulated
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model


DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-2.209814891322866.13638661550731e-075.01287908232662e-06
AZA vs. DISU-0.2777555330339320.2873046227632890.85538808681292
AZA vs. IL7-0.5003883573462630.01292177229977760.376003617518433
AZA vs. SAHA0.6089141622205970.01491930008646850.126620876568934
DISU vs. CD31.919768817305970.0001094380423102280.000613716164354308
DISU vs. IL7-0.2337453976659550.371259478330180.744446406382166
DISU vs. SAHA0.8887631405216690.002811023186895970.0432295208670501
DMSO vs. AZA-0.2064376339093340.2429730931892241
DMSO vs. CD31.990258252060475.27005531769653e-063.2339463690875e-05
DMSO vs. DISU0.06873093197678620.7849647252611970.973114958962133
DMSO vs. IL7-0.2862854447774670.1298374167052310.62814773342175
DMSO vs. SAHA0.8105209477913910.0008277958301790010.0158410242698584
HIV vs. Mock in Activation-0.02395928562280580.9802862464303060.999983755607037
HIV vs. Mock in Latency-0.02454411226835420.8863907720834170.999834320637052
IL7 vs. CD31.715953647492430.0001460796716978850.000814296927330704
SAHA vs. CD32.793711711926121.15157905433705e-091.89044622536594e-08
SAHA vs. IL71.106934699102771.17788082818482e-050.000350896751068339
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) unknown
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.839729 0.000305467
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
2FN4 X-ray 1.6Å A=23-201.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04010 MAPK signaling pathway - Homo sapiens (human)
hsa04014 Ras signaling pathway - Homo sapiens (human)
hsa04015 Rap1 signaling pathway - Homo sapiens (human)
hsa04024 cAMP signaling pathway - Homo sapiens (human)
hsa04072 Phospholipase D signaling pathway - Homo sapiens (human)
hsa04360 Axon guidance - Homo sapiens (human)
hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human)
hsa05166 HTLV-I infection - Homo sapiens (human)
hsa05205 Proteoglycans in cancer - Homo sapiens (human)
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