Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0010531
UniProt IDO15524
Primary gene name(s)SOCS1
Synonym gene name(s)SSI1, TIP3
Protein nameSuppressor of cytokine signaling 1
Protein functionSOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to be a major regulator of signaling by interleukin 6, IL6 and leukemia inhibitory factor, LIF. Regulates interferon-gamma mediated sensory neuron survival, By similarity. Probable substrate recognition component of an ECS, Elongin BC-CUL2/5-SOCS-box protein E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R signaling pathway. {ECO:0000250, ECO:0000269|PubMed:11278610, ECO:0000269|PubMed:11313480}.
Subcellular locationNucleus {ECO:0000269|PubMed:16410555}. Cytoplasmic vesicle {ECO:0000269|PubMed:16410555}. Note=Detected in perinuclear cytoplasmic vesicles upon interaction with FGFR3.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: O15524
Gene Ontology
(Biological Process)
Complete annatation
cellular response to amino acid stimulus [GO:0071230];
cytokine-mediated signaling pathway [GO:0019221];
fat cell differentiation [GO:0045444];
JAK-STAT cascade [GO:0007259];
negative regulation of insulin receptor signaling pathway [GO:0046627];
negative regulation of JAK-STAT cascade [GO:0046426];
negative regulation of tyrosine phosphorylation of Stat1 protein [GO:0042512];
negative regulation of tyrosine phosphorylation of Stat3 protein [GO:0042518];
protein ubiquitination [GO:0016567];
regulation of activation of JAK2 kinase activity [GO:0010534];
regulation of cytokine secretion [GO:0050707];
regulation of growth [GO:0040008];
regulation of interferon-gamma-mediated signaling pathway [GO:0060334];
regulation of protein phosphorylation [GO:0001932]
Gene Ontology
(Molecular Function)
Complete annatation
insulin-like growth factor receptor binding [GO:0005159];
kinase inhibitor activity [GO:0019210];
protein kinase binding [GO:0019901];
protein kinase inhibitor activity [GO:0004860]
Gene Ontology
(Cellular Component)
Complete annatation
cytoplasm [GO:0005737];
cytoplasmic, membrane-bounded vesicle [GO:0016023];
cytosol [GO:0005829];
nucleus [GO:0005634]
Protein-protein interaction114203
Phylogenetic treeO15524
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD31.239027159435660.0006046571618452120.00234458264557012
AZA vs. DISU-0.6957233387813450.1654456239169830.747228926355439
AZA vs. IL70.5560124441718580.08293341904300080.793510026625927
AZA vs. SAHA-0.4297170067790330.2609290634341210.633168818771078
DISU vs. CD3-1.944883958889959.36616979470006e-050.000534309283557413
DISU vs. IL71.241094774724480.00690400585175110.0916985799252405
DISU vs. SAHA0.269852625381950.5859967951648240.867668300753336
DMSO vs. AZA-0.1218799584749320.7125654439325921
DMSO vs. CD3-1.368165674863962.80210896965727e-050.000144716392279351
DMSO vs. DISU0.5731509402660350.2165304076143070.728536111352447
DMSO vs. IL70.6850464559500260.007049278680647860.174924893693332
DMSO vs. SAHA-0.3116374633138860.342398594303230.694549871691624
HIV vs. Mock in Activation0.2184158521149340.7313406504346320.999983755607037
HIV vs. Mock in Latency-0.3355506687805610.5439635309853760.999834320637052
IL7 vs. CD3-0.6797352821419520.03566015285072110.0836063904058048
SAHA vs. CD3-1.689302707239043.37487381296686e-062.41268255983921e-05
SAHA vs. IL7-0.9852833548334760.002017664830810670.0197830748678185
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) unknown
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 1.08504 0.000305467
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Pr55(Gag) incorporates 25310711
Pr55(Gag) binds 18172216
nucleocapsid binds 18172216
matrix binds 18172216
Tat upregulates 25943894
capsid incorporates 25310711
Envelope surface glycoprotein gp120 upregulates 25234720
Nef upregulates 16429138

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04120 Ubiquitin mediated proteolysis - Homo sapiens (human)
hsa04380 Osteoclast differentiation - Homo sapiens (human)
hsa04630 Jak-STAT signaling pathway - Homo sapiens (human)
hsa04910 Insulin signaling pathway - Homo sapiens (human)
hsa04917 Prolactin signaling pathway - Homo sapiens (human)
hsa04930 Type II diabetes mellitus - Homo sapiens (human)
hsa05145 Toxoplasmosis - Homo sapiens (human)
hsa05206 MicroRNAs in cancer - Homo sapiens (human)