Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0009999
UniProt IDP36941
Primary gene name(s)LTBR
Synonym gene name(s)D12S370, TNFCR, TNFR3, TNFRSF3
Protein nameTumor necrosis factor receptor superfamily member 3
Protein functionReceptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. Promotes apoptosis via TRAF3 and TRAF5. May play a role in the development of lymphoid organs. {ECO:0000269|PubMed:10799510, ECO:0000269|PubMed:8171323}.
Subcellular locationMembrane;
Single-pass type I membrane protein.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P36941
Gene Ontology
(Biological Process)
Complete annatation
apoptotic process [GO:0006915];
cellular response to mechanical stimulus [GO:0071260];
immune response [GO:0006955];
inflammatory response [GO:0006954];
multicellular organism development [GO:0007275];
myeloid dendritic cell differentiation [GO:0043011];
positive regulation of extrinsic apoptotic signaling pathway [GO:2001238];
positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123];
positive regulation of JNK cascade [GO:0046330];
regulation of cell proliferation [GO:0042127];
response to lipopolysaccharide [GO:0032496];
signal transduction [GO:0007165];
tumor necrosis factor-mediated signaling pathway [GO:0033209];
viral process [GO:0016032]
Gene Ontology
(Molecular Function)
Complete annatation
identical protein binding [GO:0042802];
tumor necrosis factor-activated receptor activity [GO:0005031];
ubiquitin protein ligase binding [GO:0031625]
Gene Ontology
(Cellular Component)
Complete annatation
integral component of plasma membrane [GO:0005887];
plasma membrane [GO:0005886]
Protein-protein interaction110233
Phylogenetic treeP36941
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-0.3460655955045890.337100169366630.457933641522654
AZA vs. DISU-0.0513525319318130.877910297718630.991771899371402
AZA vs. IL7-0.2604359177186370.3174081399494630.999311006273513
AZA vs. SAHA-0.1129546788303060.6924052960682610.912592238605663
DISU vs. CD30.279419185353890.4760382009384840.603769443916425
DISU vs. IL7-0.2168777021037490.4806304175455730.814651006751331
DISU vs. SAHA-0.05799612557209510.8577620161718710.962073449590206
DMSO vs. AZA0.2929852335747960.326461664315831
DMSO vs. CD30.6182060355034020.07500478966408420.134951290611421
DMSO vs. DISU0.3418656875355210.3050400507639630.811498856723186
DMSO vs. IL7-0.5446014498772480.03998104153933790.407790393237834
DMSO vs. SAHA-0.4080990496417710.1318308617729670.434908441828988
HIV vs. Mock in Activation-0.1870026957999640.7798872930120340.999983755607037
HIV vs. Mock in Latency-0.06604930492147890.8051820444024370.999834320637052
IL7 vs. CD30.08948070509583860.80024307773720.869400599014907
SAHA vs. CD30.2098082194748080.5836416916352070.683458706273237
SAHA vs. IL70.1451902825489590.6102928683173060.803384394115367
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) unknown
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 1.87103 0.00108419
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
1RF3 X-ray 3.5Å B=385-408.
4MXW X-ray 3.6Å R/S=41-211.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Tat upregulates 15857508

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human)
hsa04064 NF-kappa B signaling pathway - Homo sapiens (human)
hsa04066 HIF-1 signaling pathway - Homo sapiens (human)
hsa04672 Intestinal immune network for IgA production - Homo sapiens (human)
hsa05166 HTLV-I infection - Homo sapiens (human)
hsa05203 Viral carcinogenesis - Homo sapiens (human)