Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0009887
UniProt IDP15407
Primary gene name(s)FOSL1
Synonym gene name(s)FRA1
Protein nameFos-related antigen 1
Protein functionunknown
Subcellular locationNucleus.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P15407
Gene Ontology
(Biological Process)
Complete annatation
cellular defense response [GO:0006968];
cellular response to extracellular stimulus [GO:0031668];
chemotaxis [GO:0006935];
female pregnancy [GO:0007565];
in utero embryonic development [GO:0001701];
learning [GO:0007612];
negative regulation of cell proliferation [GO:0008285];
placenta blood vessel development [GO:0060674];
positive regulation of apoptotic process [GO:0043065];
positive regulation of cell cycle [GO:0045787];
positive regulation of cell proliferation [GO:0008284];
positive regulation of DNA-templated transcription, initiation [GO:2000144];
positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091];
pri-miRNA transcription from RNA polymerase II promoter [GO:0061614];
regulation of transcription from RNA polymerase II promoter [GO:0006357];
response to cAMP [GO:0051591];
response to corticosterone [GO:0051412];
response to cytokine [GO:0034097];
response to drug [GO:0042493];
response to gravity [GO:0009629];
response to hydrogen peroxide [GO:0042542];
response to mechanical stimulus [GO:0009612];
response to progesterone [GO:0032570];
response to virus [GO:0009615];
transcription from RNA polymerase II promoter [GO:0006366];
vitellogenesis [GO:0007296]
Gene Ontology
(Molecular Function)
Complete annatation
RNA polymerase II core promoter proximal region sequence-specific DNA binding [GO:0000978];
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding [GO:0001077];
transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding [GO:0000982];
transcription factor activity, sequence-specific DNA binding [GO:0003700]
Gene Ontology
(Cellular Component)
Complete annatation
cytosol [GO:0005829];
neuron projection [GO:0043005];
nucleus [GO:0005634];
presynaptic membrane [GO:0042734]
Protein-protein interaction113742
Phylogenetic treeP15407
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD31.151436279171810.1454214145499860.236745685903801
AZA vs. DISU0.2422909868681210.7283930913794960.974560663114398
AZA vs. IL7-0.3044060961825660.6698333314921390.999311006273513
AZA vs. SAHA-0.7687166875220420.3431145001983860.715087497949467
DISU vs. CD3-0.9231318108941870.143300176558380.247095271269848
DISU vs. IL7-0.555609489135630.35084685640180.732180363653542
DISU vs. SAHA-1.011581971505420.159975371758410.515829873292895
DMSO vs. AZA0.06088276281976470.940912596069881
DMSO vs. CD3-1.115510732963320.1767642080824150.271204073201098
DMSO vs. DISU-0.1879401037547420.7956293469583680.975613510001278
DMSO vs. IL7-0.3554435384213540.6325057431904730.920378169311359
DMSO vs. SAHA-0.8351092871858540.3164591151729520.668630329670715
HIV vs. Mock in Activation-0.1061481022139760.9101026444978960.999983755607037
HIV vs. Mock in Latency-0.5539273873816880.3256228244042760.999834320637052
IL7 vs. CD3-1.447054154421880.02969386901846640.0721896270508619
SAHA vs. CD3-1.947858853556810.01755112309549610.0412629368251367
SAHA vs. IL7-0.4686762431480450.5195902906553850.742328124475336
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) unknown
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 2.03955 0.000305467
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04310 Wnt signaling pathway - Homo sapiens (human)
hsa04380 Osteoclast differentiation - Homo sapiens (human)
hsa04657 IL-17 signaling pathway - Homo sapiens (human)
hsa05166 HTLV-I infection - Homo sapiens (human)