Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0009769
UniProt IDQ7L804
Primary gene name(s)RAB11FIP2
Synonym gene name(s)KIAA0941
Protein nameRab11 family-interacting protein 2
Protein functionA Rab11 effector binding preferentially phosphatidylinositol 3,4,5-trisphosphate, PtdInsP3 and phosphatidic acid, PA and acting in the regulation of the transport of vesicles from the endosomal recycling compartment, ERC to the plasma membrane. Involved in insulin granule exocytosis. Also involved in receptor-mediated endocytosis and membrane trafficking of recycling endosomes, probably originating from clathrin-coated vesicles. Required in a complex with MYO5B and RAB11 for the transport of NPC1L1 to the plasma membrane. Also acts as a regulator of cell polarity. {ECO:0000269|PubMed:12364336, ECO:0000269|PubMed:15304524, ECO:0000269|PubMed:16251358, ECO:0000269|PubMed:16775013, ECO:0000269|PubMed:19542231}.
Subcellular locationCell membrane;
Peripheral membrane protein. Recycling endosome membrane;
Peripheral membrane protein. Note=Translocates with RAB11A from the vesicles of the endocytic recycling compartment, ERC to the plasma membrane.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q7L804
Gene Ontology
(Biological Process)
Complete annatation
establishment of cell polarity [GO:0030010];
insulin secretion involved in cellular response to glucose stimulus [GO:0035773];
regulated exocytosis [GO:0045055];
renal water homeostasis [GO:0003091]
Gene Ontology
(Molecular Function)
Complete annatation
protein homodimerization activity [GO:0042803];
protein kinase binding [GO:0019901];
Rab GTPase binding [GO:0017137]
Gene Ontology
(Cellular Component)
Complete annatation
cytoplasmic vesicle membrane [GO:0030659];
endosome [GO:0005768];
intracellular membrane-bounded organelle [GO:0043231];
nucleoplasm [GO:0005654];
plasma membrane [GO:0005886];
recycling endosome membrane [GO:0055038]
Protein-protein interaction116514
Phylogenetic treeQ7L804
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
      Negatively associated
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-0.2859526947777540.3859120478199170.507633652010979
AZA vs. DISU0.1384007604622560.5870130372003930.955158276076142
AZA vs. IL70.2877705560656970.1381885872442010.901590674162402
AZA vs. SAHA-0.2548329628842750.3012483169721830.673341804572758
DISU vs. CD30.4114326892147710.2640190385235740.392216199869657
DISU vs. IL70.1411159476820330.5774815334646020.865274108498704
DISU vs. SAHA-0.3929217607165910.1796260266659850.545717469533298
DMSO vs. AZA-0.04838708673476760.7758716087862461
DMSO vs. CD30.2275694135042570.4798727468814790.589808512015132
DMSO vs. DISU-0.1880357928587040.444172388813690.885270626131108
DMSO vs. IL70.3431941893451050.05890325310391010.469550803169272
DMSO vs. SAHA-0.2144009223929060.3677913376118540.715956198823366
HIV vs. Mock in Activation-0.03938384456511130.9498472015383430.999983755607037
HIV vs. Mock in Latency0.08116624183589950.6262466777396790.999834320637052
IL7 vs. CD30.5827288316356980.07265435719424880.147909120203797
SAHA vs. CD30.005816376870899650.987078482467180.990958146078237
SAHA vs. IL7-0.5468446358209960.02623263161002650.11993651467684
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) unknown
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.18909 0.266053
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
2GZD X-ray 2.4Å C/D=410-512.
2GZH X-ray 2.4Å B=410-512.
2K6S NMR - A/B=450-489.
3TSO X-ray 1.8Å C/D=440-512.
4C4P X-ray 2.0Å B=410-512.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04144 Endocytosis - Homo sapiens (human)