Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0009648
UniProt IDQ13261
Primary gene name(s)IL15RA
Synonym gene name(s)unknown
Protein nameInterleukin-15 receptor subunit alpha
Protein functionHigh-affinity receptor for interleukin-15. Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Expression of different isoforms may alter or interfere with signal transduction. Isoform 5, isoform 6, isoform 7 and isoform 8 do not bind IL15. Signal transduction involves SYK. {ECO:0000269|PubMed:11714793, ECO:0000269|PubMed:8530383}.
Subcellular locationMembrane {ECO:0000269|PubMed:10480910};
Single-pass type I membrane protein {ECO:0000269|PubMed:10480910}. Nucleus membrane {ECO:0000269|PubMed:10480910};
Single-pass type I membrane protein {ECO:0000269|PubMed:10480910}. Note=Mainly found associated with the nuclear membrane.;
SUBCELLULAR LOCATION: Isoform 5: Endoplasmic reticulum membrane;
Single-pass type I membrane protein. Golgi apparatus membrane;
Single-pass type I membrane protein. Cytoplasmic vesicle membrane;
Single-pass type I membrane protein. Membrane;
Single-pass type I membrane protein. Note=Isoform 5, isoform 6, isoform 7 and isoform 8 are associated with endoplasmic reticulum, Golgi and cytoplasmic vesicles, but not with the nuclear membrane.;
SUBCELLULAR LOCATION: Isoform 6: Endoplasmic reticulum membrane;
Single-pass type I membrane protein. Golgi apparatus membrane;
Single-pass type I membrane protein. Cytoplasmic vesicle membrane;
Single-pass type I membrane protein. Membrane;
Single-pass type I membrane protein. Note=Isoform 5, isoform 6, isoform 7 and isoform 8 are associated with endoplasmic reticulum, Golgi and cytoplasmic vesicles, but not with the nuclear membrane.;
SUBCELLULAR LOCATION: Isoform 7: Endoplasmic reticulum membrane;
Single-pass type I membrane protein. Golgi apparatus membrane;
Single-pass type I membrane protein. Cytoplasmic vesicle membrane;
Single-pass type I membrane protein. Membrane;
Single-pass type I membrane protein. Note=Isoform 5, isoform 6, isoform 7 and isoform 8 are associated with endoplasmic reticulum, Golgi and cytoplasmic vesicles, but not with the nuclear membrane.;
SUBCELLULAR LOCATION: Isoform 8: Endoplasmic reticulum membrane;
Single-pass type I membrane protein. Golgi apparatus membrane;
Single-pass type I membrane protein. Cytoplasmic vesicle membrane;
Single-pass type I membrane protein. Membrane;
Single-pass type I membrane protein. Note=Isoform 5, isoform 6, isoform 7 and isoform 8 are associated with endoplasmic reticulum, Golgi and cytoplasmic vesicles, but not with the nuclear membrane.;
SUBCELLULAR LOCATION: Soluble interleukin-15 receptor subunit alpha: Secreted, extracellular space.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q13261
Gene Ontology
(Biological Process)
Complete annatation
cell proliferation [GO:0008283];
signal transduction [GO:0007165]
Gene Ontology
(Molecular Function)
Complete annatation
cytokine receptor activity [GO:0004896];
signal transducer activity [GO:0004871]
Gene Ontology
(Cellular Component)
Complete annatation
cytoplasmic vesicle membrane [GO:0030659];
endoplasmic reticulum membrane [GO:0005789];
extracellular space [GO:0005615];
Golgi membrane [GO:0000139];
integral component of membrane [GO:0016021];
nuclear membrane [GO:0031965];
plasma membrane [GO:0005886]
Protein-protein interaction109814
Phylogenetic treeQ13261
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
      unknown
Brass et al., Science, 2008
      unknown
Smith et al., J. Immunol, 2010
      unknown
Interferon-stimulated
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model


DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD32.306166876071942.59535726243598e-115.02792090738241e-10
AZA vs. DISU0.5046920729594140.05404630713514890.517266053177927
AZA vs. IL70.5256816974294880.01000497395464480.323615820640261
AZA vs. SAHA0.1034886850619980.6846252021300360.909014383590959
DISU vs. CD3-1.813914026263821.38116483017203e-061.27963605716123e-05
DISU vs. IL70.01167823126043570.9639750202703510.994449950565863
DISU vs. SAHA-0.3995067912212140.1817775739288730.54736659673967
DMSO vs. AZA-0.02606710327319920.8872170339331191
DMSO vs. CD3-2.348242152129123.75921516138078e-127.40295116420934e-11
DMSO vs. DISU-0.5341741110837660.03440814219891510.37439039923296
DMSO vs. IL70.5595641890115630.003453333884124830.115944339205305
DMSO vs. SAHA0.1244224716170930.6129349027363910.872103223811296
HIV vs. Mock in Activation-0.1107761221110610.8589431049623740.999983755607037
HIV vs. Mock in Latency-0.3698853355286190.03545020831645670.721741511723139
IL7 vs. CD3-1.772408113787289.90990544069703e-081.20851136494843e-06
SAHA vs. CD3-2.227056307937222.02087235834369e-093.16904749638288e-08
SAHA vs. IL7-0.4258334038011980.09117771793958810.27210709170884
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) unknown
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.848481 0.000305467
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
2ERS NMR - A=31-96.
2Z3Q X-ray 1.8Å B/D=31-132.
2Z3R X-ray 2.0Å B/D/F/H/J/L/N/P=31-132.
4GS7 X-ray 2.3Å D=30-97.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Envelope surface glycoprotein gp120 downregulates 24162774

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human)
hsa04630 Jak-STAT signaling pathway - Homo sapiens (human)
hsa04672 Intestinal immune network for IgA production - Homo sapiens (human)
hsa05166 HTLV-I infection - Homo sapiens (human)
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