Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0009321
UniProt IDQ13105
Primary gene name(s)ZBTB17
Synonym gene name(s)MIZ1, ZNF151, ZNF60
Protein nameZinc finger and BTB domain-containing protein 17
Protein functionTranscription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. Plays a critical role in early lymphocyte development, where it is essential to prevent apoptosis in lymphoid precursors, allowing them to survive in response to IL7 and undergo proper lineage commitment. Has been shown to bind to the promoters of adenovirus major late protein and cyclin D1 and activate transcription. Required for early embryonic development during gastrulation. Represses RB1 transcription; this repression can be blocked by interaction with ZBTB49 isoform 3/ZNF509S1, PubMed:25245946. {ECO:0000269|PubMed:16142238, ECO:0000269|PubMed:19164764, ECO:0000269|PubMed:25245946, ECO:0000269|PubMed:9308237, ECO:0000269|PubMed:9312026}.
Subcellular locationNucleus {ECO:0000269|PubMed:14739298, ECO:0000269|PubMed:9312026}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q13105
Gene Ontology
(Biological Process)
Complete annatation
ectoderm development [GO:0007398];
gastrulation with mouth forming second [GO:0001702];
IRE1-mediated unfolded protein response [GO:0036498];
negative regulation of cell cycle [GO:0045786];
positive regulation of protein targeting to mitochondrion [GO:1903955];
positive regulation of transcription, DNA-templated [GO:0045893];
regulation of mitophagy [GO:1903146];
transcription, DNA-templated [GO:0006351]
Gene Ontology
(Molecular Function)
Complete annatation
DNA binding [GO:0003677];
metal ion binding [GO:0046872];
transcription factor activity, sequence-specific DNA binding [GO:0003700]
Gene Ontology
(Cellular Component)
Complete annatation
nucleoplasm [GO:0005654]
Protein-protein interaction113503
Phylogenetic treeQ13105
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-0.441532165574560.2619062723808930.376091019181099
AZA vs. DISU0.1721561612376160.4983977877427520.934754900374469
AZA vs. IL7-0.09979479551118180.6078322151657980.999311006273513
AZA vs. SAHA-0.6216025459335550.01210093861886240.110209176395356
DISU vs. CD30.6008272083027430.1248946549788030.221907358457153
DISU vs. IL7-0.2817385200482310.2659077625654570.652284375210954
DISU vs. SAHA-0.7908892293557930.007313964133493060.0839518305071393
DMSO vs. AZA0.01113624161494410.9477842616510051
DMSO vs. CD30.4401609113066520.2460442481302170.351260732780568
DMSO vs. DISU-0.16320411718170.5057278205139390.910539373912596
DMSO vs. IL7-0.1033355653947150.5700645691597990.903436831021822
DMSO vs. SAHA-0.637192899085770.007769463974507510.0762328070050798
HIV vs. Mock in Activation0.2617437373767740.7613856545238450.999983755607037
HIV vs. Mock in Latency0.07742654349932660.6435290199784550.999834320637052
IL7 vs. CD30.3467077940642440.3744690160829190.511682665163434
SAHA vs. CD3-0.2029939875054180.6293754168543370.72214767260506
SAHA vs. IL7-0.5237404179293080.03368054471859560.14098876175732
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) unknown
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.019538 0.939108
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
2LVR NMR - A=500-581.
2LVT NMR - A=500-581.
2LVU NMR - A=500-581.
2M0D NMR - A=416-526.
2M0E NMR - A=416-526.
2M0F NMR - A=416-526.
2N25 NMR - A=304-414.
2N26 NMR - A=304-414.
2Q81 X-ray 2.1Å A/B/C/D=2-115.
3M52 X-ray 2.5Å A/B=1-115.
4U2M X-ray 2.2Å A/B/C/D=2-115.
4U2N X-ray 2.3Å A/B=2-115.
5ION NMR - A=714-742.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04110 Cell cycle - Homo sapiens (human)
hsa05202 Transcriptional misregulation in cancer - Homo sapiens (human)