Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0009277
UniProt IDO14640
Primary gene name(s)DVL1
Synonym gene name(s)unknown
Protein nameSegment polarity protein dishevelled homolog DVL-1
Protein functionParticipates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction, NMJ.
Subcellular locationCell membrane {ECO:0000250};
Peripheral membrane protein {ECO:0000250};
Cytoplasmic side {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Note=Localizes at the cell membrane upon interaction with frizzled family members. {ECO:0000250}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: O14640
Gene Ontology
(Biological Process)
Complete annatation
axon extension [GO:0048675];
axon guidance [GO:0007411];
beta-catenin destruction complex disassembly [GO:1904886];
canonical Wnt signaling pathway [GO:0060070];
cochlea morphogenesis [GO:0090103];
collateral sprouting [GO:0048668];
convergent extension involved in neural plate elongation [GO:0022007];
cytoplasmic microtubule organization [GO:0031122];
dendrite morphogenesis [GO:0048813];
dendritic spine morphogenesis [GO:0060997];
intracellular signal transduction [GO:0035556];
negative regulation of canonical Wnt signaling pathway [GO:0090090];
negative regulation of protein binding [GO:0032091];
negative regulation of protein kinase activity [GO:0006469];
neural tube development [GO:0021915];
neuromuscular junction development [GO:0007528];
neurotransmitter secretion [GO:0007269];
planar cell polarity pathway involved in neural tube closure [GO:0090179];
positive regulation of canonical Wnt signaling pathway [GO:0090263];
positive regulation of excitatory postsynaptic potential [GO:2000463];
positive regulation of neuron projection development [GO:0010976];
positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436];
positive regulation of protein localization to presynapse [GO:1905386];
positive regulation of protein phosphorylation [GO:0001934];
positive regulation of transcription, DNA-templated [GO:0045893];
positive regulation of Wnt signaling pathway [GO:0030177];
prepulse inhibition [GO:0060134];
presynapse assembly [GO:0099054];
protein localization to microtubule [GO:0035372];
protein localization to nucleus [GO:0034504];
protein stabilization [GO:0050821];
receptor clustering [GO:0043113];
regulation of cellular protein localization [GO:1903827];
regulation of neurotransmitter levels [GO:0001505];
skeletal muscle acetylcholine-gated channel clustering [GO:0071340];
social behavior [GO:0035176];
synapse organization [GO:0050808];
transcription from RNA polymerase II promoter [GO:0006366];
Wnt signaling pathway, planar cell polarity pathway [GO:0060071]
Gene Ontology
(Molecular Function)
Complete annatation
enzyme binding [GO:0019899];
frizzled binding [GO:0005109];
identical protein binding [GO:0042802];
protein kinase binding [GO:0019901]
Gene Ontology
(Cellular Component)
Complete annatation
axon [GO:0030424];
clathrin-coated vesicle [GO:0030136];
cytoplasmic, membrane-bounded vesicle [GO:0016023];
cytoplasmic vesicle [GO:0031410];
cytosol [GO:0005829];
dendrite [GO:0030425];
growth cone [GO:0030426];
microtubule [GO:0005874];
neuronal cell body [GO:0043025];
neuron projection [GO:0043005];
plasma membrane [GO:0005886];
presynapse [GO:0098793];
synapse [GO:0045202];
Wnt signalosome [GO:1990909]
Protein-protein interaction108188
Phylogenetic treeO14640
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
      Yes - Two siRNA pools inhibit HIV replication and inhibition of Tat-mediated transactivation of the HIV LTR is also observed
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD30.2218358945308470.5821660310818230.689107548925252
AZA vs. DISU0.03357126731802650.8945506314963590.993937521279788
AZA vs. IL7-0.0853688026740020.6694598311181390.999311006273513
AZA vs. SAHA-0.1122147247532880.6462511938155130.891270859613453
DISU vs. CD3-0.2008412293080740.6360469142059290.741284303752913
DISU vs. IL7-0.1286860356498450.6098849881931570.880528901107045
DISU vs. SAHA-0.1428157602850040.6242835121560720.881282953512941
DMSO vs. AZA-0.0211113535016810.900235049105341
DMSO vs. CD3-0.2546225156051710.5192447335230040.625893895865262
DMSO vs. DISU-0.05671420473455710.8163839168126940.980295078677667
DMSO vs. IL7-0.05656133339943250.7539897625555220.951631847120623
DMSO vs. SAHA-0.0960116746125290.6843616451640950.901903272327721
HIV vs. Mock in Activation0.3998275617928970.6214375187528650.999983755607037
HIV vs. Mock in Latency0.04598730586590390.782232514517710.999834320637052
IL7 vs. CD3-0.302574784707950.4710590346791260.603397237411001
SAHA vs. CD3-0.3567716762463160.3840834100486680.500652474001991
SAHA vs. IL7-0.02951485586708160.9036954665678180.963456076316804
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) unknown
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.260028 0.109429
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
HIV-1 virus replication enhanced by expression of human gene 18976975

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04150 mTOR signaling pathway - Homo sapiens (human)
hsa04310 Wnt signaling pathway - Homo sapiens (human)
hsa04330 Notch signaling pathway - Homo sapiens (human)
hsa04390 Hippo signaling pathway - Homo sapiens (human)
hsa04550 Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)
hsa04916 Melanogenesis - Homo sapiens (human)
hsa05166 HTLV-I infection - Homo sapiens (human)
hsa05200 Pathways in cancer - Homo sapiens (human)
hsa05217 Basal cell carcinoma - Homo sapiens (human)
hsa05224 Breast cancer - Homo sapiens (human)