Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0009019
UniProt IDQ9Y4G6
Primary gene name(s)TLN2
Synonym gene name(s)KIAA0320
Protein nameTalin-2
Protein functionAs a major component of focal adhesion plaques that links integrin to the actin cytoskeleton, may play an important role in cell adhesion. Recruits PIP5K1C to focal adhesion plaques and strongly activates its kinase activity, By similarity. {ECO:0000250}.
Subcellular locationCytoplasm {ECO:0000269|PubMed:27223613}. Cell junction, focal adhesion {ECO:0000269|PubMed:12422219}. Cell junction, synapse {ECO:0000269|PubMed:12422219}. Cell membrane;
Peripheral membrane protein;
Cytoplasmic side {ECO:0000269|PubMed:12422219}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12422219}. Note=Focal adhesion plaques and synapses, PubMed:12422219. {ECO:0000269|PubMed:12422219}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q9Y4G6
Gene Ontology
(Biological Process)
Complete annatation
cell adhesion [GO:0007155];
cell-cell junction assembly [GO:0007043];
cytoskeletal anchoring at plasma membrane [GO:0007016]
Gene Ontology
(Molecular Function)
Complete annatation
actin binding [GO:0003779];
structural constituent of cytoskeleton [GO:0005200];
structural molecule activity [GO:0005198]
Gene Ontology
(Cellular Component)
Complete annatation
actin cytoskeleton [GO:0015629];
cell-cell junction [GO:0005911];
cytoplasm [GO:0005737];
focal adhesion [GO:0005925];
plasma membrane [GO:0005886];
ruffle [GO:0001726];
synapse [GO:0045202]
Protein-protein interaction123717
Phylogenetic treeQ9Y4G6
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-0.5870639628917790.482729734599660.601546305075326
AZA vs. DISU0.1843250567420350.8549317863696030.989951370113767
AZA vs. IL7-0.2862994212277480.7566465583889580.999311006273513
AZA vs. SAHA0.5583194031102430.5435005420983250.84484949720301
DISU vs. CD30.7490136185301680.3871136021560540.52161888253333
DISU vs. IL7-0.4783800268000040.610241479654150.880745840668867
DISU vs. SAHA0.3762168927763970.6859738973608870.906929947389411
DMSO vs. AZA0.2287581587211030.8083349541173781
DMSO vs. CD30.7866614620267970.2713905560109420.379901386945256
DMSO vs. DISU0.04088784596876870.9657491594492460.994306419554359
DMSO vs. IL7-0.5051862820572660.5543319586800270.899327838689346
DMSO vs. SAHA0.3271818254512670.6979598077313020.908512045825898
HIV vs. Mock in Activationunknownunknownunknown
HIV vs. Mock in Latency0.1682899025914970.7835347357606660.999834320637052
IL7 vs. CD3unknownunknownunknown
SAHA vs. CD31.111136990396520.09811262338950670.171285989237196
SAHA vs. IL70.8395697259977120.3108053767164140.559879323592084
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change 1.228573996
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) unknown
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.231554 0.578539
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
retropepsin cleaves 12119179
matrix interacts with 22017400

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04015 Rap1 signaling pathway - Homo sapiens (human)
hsa04510 Focal adhesion - Homo sapiens (human)
hsa04611 Platelet activation - Homo sapiens (human)
hsa05166 HTLV-I infection - Homo sapiens (human)