Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0008888
UniProt IDP09668
Primary gene name(s)CTSH
Synonym gene name(s)CPSB
Protein namePro-cathepsin H [Cleaved into: Cathepsin H mini chain; Cathepsin H
Protein functionImportant for the overall degradation of proteins in lysosomes.
Subcellular locationLysosome.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P09668
Gene Ontology
(Biological Process)
Complete annatation
adaptive immune response [GO:0002250];
antigen processing and presentation [GO:0019882];
bradykinin catabolic process [GO:0010815];
cellular protein metabolic process [GO:0044267];
cellular response to thyroid hormone stimulus [GO:0097067];
dichotomous subdivision of terminal units involved in lung branching [GO:0060448];
ERK1 and ERK2 cascade [GO:0070371];
immune response-regulating signaling pathway [GO:0002764];
membrane protein proteolysis [GO:0033619];
metanephros development [GO:0001656];
negative regulation of apoptotic process [GO:0043066];
neuropeptide catabolic process [GO:0010813];
positive regulation of angiogenesis [GO:0045766];
positive regulation of apoptotic signaling pathway [GO:2001235];
positive regulation of cell migration [GO:0030335];
positive regulation of cell proliferation [GO:0008284];
positive regulation of epithelial cell migration [GO:0010634];
positive regulation of gene expression [GO:0010628];
positive regulation of peptidase activity [GO:0010952];
protein destabilization [GO:0031648];
proteolysis [GO:0006508];
proteolysis involved in cellular protein catabolic process [GO:0051603];
response to retinoic acid [GO:0032526];
surfactant homeostasis [GO:0043129];
T cell mediated cytotoxicity [GO:0001913];
zymogen activation [GO:0031638]
Gene Ontology
(Molecular Function)
Complete annatation
aminopeptidase activity [GO:0004177];
cysteine-type endopeptidase activator activity involved in apoptotic process [GO:0008656];
cysteine-type endopeptidase activity [GO:0004197];
cysteine-type peptidase activity [GO:0008234];
endopeptidase activity [GO:0004175];
HLA-A specific activating MHC class I receptor activity [GO:0030108];
peptidase activity [GO:0008233];
serine-type endopeptidase activity [GO:0004252];
thyroid hormone binding [GO:0070324]
Gene Ontology
(Cellular Component)
Complete annatation
alveolar lamellar body [GO:0097208];
cytosol [GO:0005829];
extracellular exosome [GO:0070062];
extracellular space [GO:0005615];
lysosome [GO:0005764];
multivesicular body lumen [GO:0097486]
Protein-protein interaction107892
Phylogenetic treeP09668
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-0.07393047537868450.8251665370745530.881175431967385
AZA vs. DISU-0.5442406121820560.09785764770306850.63649283006639
AZA vs. IL70.9882627210977715.57922402832922e-070.000289984978548298
AZA vs. SAHA-0.138830393022180.5877890503363090.863580131069154
DISU vs. CD3-0.48100347602810.2273289646141090.351066162544113
DISU vs. IL71.522097144314317.39214721101611e-070.000101306017460062
DISU vs. SAHA0.4080390301843630.2381040420335310.616468994586384
DMSO vs. AZA-0.02132253614019460.9223015837815351
DMSO vs. CD30.04349348329606010.8943523855362840.928241039483576
DMSO vs. DISU0.521736443296320.1060794667237660.580917150231104
DMSO vs. IL71.015970157660084.02198845339541e-082.69833495471518e-05
DMSO vs. SAHA-0.1227901158338520.621758405742170.876247034763022
HIV vs. Mock in Activation0.4020566773385690.5234912228843110.999983755607037
HIV vs. Mock in Latency0.3408059253330730.04383582581760060.816607594509553
IL7 vs. CD31.067505211719970.001075442436888620.00451159027309272
SAHA vs. CD3-0.08695879167857490.8085372134826660.863708804368059
SAHA vs. IL7-1.127369431779955.9110669052842e-060.000200683384077149
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander 0.843 2.46E-06 3.57E-05
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change 2.500478679
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) unknown
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -0.333518 0.011166
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

Drugbank ID Drug Name Drug Status Pharmacological Action Drug Action
DB03120 Para-Toluene Sulfonate experimental unknown unknown
DB02140 N1-(1-Dimethylcarbamoyl-2-Phenyl-Ethyl)-2-Oxo-N4-(2-Pyridin-2-Yl-Ethyl)-Succinamide experimental unknown unknown
DB04126 N-[1-Hydroxycarboxyethyl-Carbonyl]Leucylamino-2-Methyl-Butane experimental unknown unknown

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
1BZN Model - B=116-335.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Vpr upregulates 23874603

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04142 Lysosome - Homo sapiens (human)
hsa04210 Apoptosis - Homo sapiens (human)