Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0008534
UniProt IDQ03060
Primary gene name(s)CREM
Synonym gene name(s)unknown
Protein namecAMP-responsive element modulator
Protein functionTranscriptional regulator that binds the cAMP response element, CRE, a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and is involved in spermatid maturation, PubMed:10373550. {ECO:0000269|PubMed:10373550}.; FUNCTION: Isoform 6: May play a role in the regulation of the circadian clock: acts as a transcriptional repressor of the core circadian component PER1 by directly binding to cAMP response elements in its promoter. {ECO:0000250}.
Subcellular locationNucleus.;
SUBCELLULAR LOCATION: Isoform 6: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q03060
Gene Ontology
(Biological Process)
Complete annatation
cell differentiation [GO:0030154];
fatty acid metabolic process [GO:0006631];
glucose metabolic process [GO:0006006];
glycosphingolipid metabolic process [GO:0006687];
multicellular organism development [GO:0007275];
positive regulation of transcription from RNA polymerase II promoter [GO:0045944];
regulation of circadian rhythm [GO:0042752];
regulation of transcription, DNA-templated [GO:0006355];
retinoic acid receptor signaling pathway [GO:0048384];
rhythmic process [GO:0048511];
signal transduction [GO:0007165];
spermatogenesis [GO:0007283];
transcription, DNA-templated [GO:0006351]
Gene Ontology
(Molecular Function)
Complete annatation
cAMP response element binding protein binding [GO:0008140];
core promoter sequence-specific DNA binding [GO:0001046];
DNA binding [GO:0003677];
transcription factor activity, sequence-specific DNA binding [GO:0003700]
Gene Ontology
(Cellular Component)
Complete annatation
cytoplasm [GO:0005737];
nucleus [GO:0005634];
transcription factor complex [GO:0005667]
Protein-protein interaction107780
Phylogenetic treeQ03060
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD33.0140605696814400
AZA vs. DISU0.3356488042648050.1908399897855860.778706964639598
AZA vs. IL70.5730318524648250.003431502159079610.177742378157412
AZA vs. SAHA0.1291832259402490.6013865093681880.868625481395792
DISU vs. CD3-2.691567959040246.35269614690515e-122.00335861335666e-10
DISU vs. IL70.2271382451289420.373441717269750.746349367869539
DISU vs. SAHA-0.2033828884064180.4879078976902790.817382218304424
DMSO vs. AZA-0.1525036410215680.5090259721880091
DMSO vs. CD3-3.1710975205034600
DMSO vs. DISU-0.4882100624968990.05506062376395390.457565398072315
DMSO vs. IL70.731663395935070.0004276117200864290.031585837847527
DMSO vs. SAHA0.2747654564466990.2666246393703790.615454118540509
HIV vs. Mock in Activation0.4276122409744950.4922261264460080.999983755607037
HIV vs. Mock in Latency0.2121307520078180.4195345687191780.999834320637052
IL7 vs. CD3-2.436007317507637.15094650161063e-132.12596088005477e-11
SAHA vs. CD3-2.907433121548153.44169137633799e-141.38310104110436e-12
SAHA vs. IL7-0.4448236227927970.0715119937759060.233226264426224
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
0.7732 0.02159

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) unknown
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.87046 0.000305467
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Tat activates 10853989
Tat upregulates 10660577

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04261 Adrenergic signaling in cardiomyocytes - Homo sapiens (human)
hsa05166 HTLV-I infection - Homo sapiens (human)