Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0008456
UniProt IDQ04900
Primary gene name(s)CD164
Synonym gene name(s)unknown
Protein nameSialomucin core protein 24
Protein functionSialomucin that may play a key role in hematopoiesis by facilitating the adhesion of CD34(+ cells to the stroma and by negatively regulating CD34(+CD38(lo/- cell proliferation. Modulates the migration of umbilical cord blood CD133+ cells and this is mediated through the CXCL12/CXCR4 axis. May play an important role in prostate cancer metastasis and the infiltration of bone marrow by cancer cells. Promotes myogenesis by enhancing CXCR4-dependent cell motility. Positively regulates myoblast migration and promotes myoblast fusion into myotubes, By similarity. {ECO:0000250, ECO:0000269|PubMed:16859559, ECO:0000269|PubMed:17077324, ECO:0000269|PubMed:9763543}.
Subcellular locationLysosome membrane {ECO:0000269|PubMed:11027692};
Single-pass type I membrane protein {ECO:0000269|PubMed:11027692}. Endosome membrane {ECO:0000269|PubMed:11027692};
Single-pass type I membrane protein {ECO:0000269|PubMed:11027692}. Cell membrane {ECO:0000269|PubMed:11027692};
Single-pass type I membrane protein {ECO:0000269|PubMed:11027692}.;
SUBCELLULAR LOCATION: Isoform 2: Secreted {ECO:0000305}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q04900
Gene Ontology
(Biological Process)
Complete annatation
cell adhesion [GO:0007155];
hemopoiesis [GO:0030097];
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157];
immune response [GO:0006955];
multicellular organism development [GO:0007275];
muscle organ development [GO:0007517];
negative regulation of cell adhesion [GO:0007162];
negative regulation of cell proliferation [GO:0008285];
signal transduction [GO:0007165]
Gene Ontology
(Molecular Function)
Complete annatation
Gene Ontology
(Cellular Component)
Complete annatation
endosome [GO:0005768];
endosome membrane [GO:0010008];
extracellular region [GO:0005576];
integral component of plasma membrane [GO:0005887];
lysosomal membrane [GO:0005765];
lysosome [GO:0005764];
plasma membrane [GO:0005886]
Protein-protein interaction114297
Phylogenetic treeQ04900
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD30.1204866391887470.7131118208835580.79656276323701
AZA vs. DISU0.1510968163863220.5494624464883270.946149979251203
AZA vs. IL70.01881947392739810.921748261658690.999311006273513
AZA vs. SAHA-0.04258255613714080.8611284837974180.967511288959921
DISU vs. CD30.01803315447372190.960278476251390.974322673071014
DISU vs. IL7-0.1414845763968170.5735540810419840.863368710742884
DISU vs. SAHA-0.19246984592880.5087653035150870.830443297940358
DMSO vs. AZA-0.06282169997496150.7064577954856021
DMSO vs. CD3-0.1932674545898150.5460314517682450.65017102599499
DMSO vs. DISU-0.2153587398570710.376595473078250.855614922250751
DMSO vs. IL70.08864564400490040.62078991872330.917286151060713
DMSO vs. SAHA0.01328191904795890.9549713620192870.989349060414757
HIV vs. Mock in Activation-0.1711299569044080.7834341171079910.999983755607037
HIV vs. Mock in Latency0.162925172224650.3213642708397680.999834320637052
IL7 vs. CD3-0.09389062572115330.7701029534364040.847626952856912
SAHA vs. CD3-0.1873270670731710.5974010443962810.695438046864772
SAHA vs. IL7-0.06476137092021550.7899014790038320.907792088684176
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
-0.353 0.04872

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) unknown
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.212974 0.127084
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Nef downregulates 25275127
Vpu downregulates 25275127
HIV-1 virus replication enhanced by expression of human gene 18854154
HIV-1 virus replication inhibited by expression of human gene 25980612

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04142 Lysosome - Homo sapiens (human)