Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0008282
UniProt IDQ9NR34
Primary gene name(s)MAN1C1
Synonym gene name(s)MAN1A3, MAN1C
Protein nameMannosyl-oligosaccharide 1,2-alpha-mannosidase IC
Protein functionInvolved in the maturation of Asn-linked oligosaccharides. Trim alpha-1,2-linked mannose residues from Man(9GlcNAc(2 to produce first Man(8GlcNAc(2 then Man(6GlcNAc and a small amount of Man(5GlcNAc.
Subcellular locationGolgi apparatus membrane;
Single-pass type II membrane protein.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q9NR34
Gene Ontology
(Biological Process)
Complete annatation
Golgi apparatus mannose trimming [GO:1904381];
N-glycan processing [GO:0006491];
protein N-linked glycosylation [GO:0006487]
Gene Ontology
(Molecular Function)
Complete annatation
calcium ion binding [GO:0005509];
mannosyl-oligosaccharide 1,2-alpha-mannosidase activity [GO:0004571]
Gene Ontology
(Cellular Component)
Complete annatation
endoplasmic reticulum [GO:0005783];
extracellular exosome [GO:0070062];
Golgi membrane [GO:0000139];
integral component of Golgi membrane [GO:0030173]
Protein-protein interaction121395
Phylogenetic treeQ9NR34
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
      unknown
Brass et al., Science, 2008
      unknown
Smith et al., J. Immunol, 2010
      unknown
Interferon-stimulated
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model


DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-0.282087301441790.4099103394189970.531684047824709
AZA vs. DISU-0.09803918610212490.6988776253671860.969609310121983
AZA vs. IL70.2508980814724770.194008170381210.957061395935303
AZA vs. SAHA-0.109068923295510.6552457603672940.895323326702085
DISU vs. CD30.1719161955471480.6412864623713070.74478705554488
DISU vs. IL70.3403542068513250.1772421581197690.545332982554337
DISU vs. SAHA-0.01026446570335090.971904194774960.995121954739427
DMSO vs. AZA-0.007446067318597630.9664959626696821
DMSO vs. CD30.2579305735373230.4469574076696810.558823275455166
DMSO vs. DISU0.08727866323092980.720899681491580.963287657392988
DMSO vs. IL70.266331217644130.1401415366565230.639804259569076
DMSO vs. SAHA-0.1072882871119440.649343032848190.887621949322553
HIV vs. Mock in Activation-0.1946460396699310.7909289293904620.999983755607037
HIV vs. Mock in Latency-0.4863758901058370.003409072890902750.159752607650834
IL7 vs. CD30.5420180974698340.1042157055174790.195792512684153
SAHA vs. CD30.1474504467589540.6834621724614950.766295285990234
SAHA vs. IL7-0.3643181046341320.1357178017080320.34517687911253
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
0.6857 0.008426

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) unknown
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -0.293187 0.0303696
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
218918_at 1.72 No downregulated in CD8+ cells

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Envelope surface glycoprotein gp120 processed by 12560567
2283726
2355006
2406237
2542563
2649653
2829950
8218172
8892864
Envelope transmembrane glycoprotein gp41 processed by 1736542
2829950
3099781
3264072
8093218
Envelope surface glycoprotein gp160; precursor processed by 2187500
2541446
2542563
2649653
2829950
8673525
9109416
11530211

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa00510 N-Glycan biosynthesis - Homo sapiens (human)
hsa01100 Metabolic pathways - Homo sapiens (human)
hsa04141 Protein processing in endoplasmic reticulum - Homo sapiens (human)
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