Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0008219
UniProt IDQ9UQ16
Primary gene name(s)DNM3
Synonym gene name(s)KIAA0820
Protein nameDynamin-3
Protein functionMicrotubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis, By similarity. {ECO:0000250}.
Subcellular locationCytoplasm {ECO:0000305}. Cytoplasm, cytoskeleton {ECO:0000305}. Note=Microtubule-associated. {ECO:0000305}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q9UQ16
Gene Ontology
(Biological Process)
Complete annatation
dynamin family protein polymerization involved in mitochondrial fission [GO:0003374];
endocytosis [GO:0006897];
filopodium assembly [GO:0046847];
membrane fusion [GO:0061025];
mitochondrial fission [GO:0000266];
negative regulation of dendritic spine morphogenesis [GO:0061002];
positive regulation of filopodium assembly [GO:0051491];
receptor internalization [GO:0031623];
synapse assembly [GO:0007416]
Gene Ontology
(Molecular Function)
Complete annatation
GTPase activity [GO:0003924];
GTP binding [GO:0005525]
Gene Ontology
(Cellular Component)
Complete annatation
axon [GO:0030424];
dendritic spine [GO:0043197];
dendritic spine head [GO:0044327];
extracellular exosome [GO:0070062];
Golgi apparatus [GO:0005794];
microtubule [GO:0005874];
mitochondrion [GO:0005739];
perinuclear region of cytoplasm [GO:0048471];
photoreceptor inner segment [GO:0001917];
postsynaptic density [GO:0014069];
synaptic cleft [GO:0043083]
Protein-protein interaction117515
Phylogenetic treeQ9UQ16
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-1.596983336539322.9396408465221e-050.000163733432515821
AZA vs. DISU1.041090583611880.0002300904399435980.0289296574695227
AZA vs. IL7-0.1231962118493090.6286229950969790.999311006273513
AZA vs. SAHA1.704718566436860.001897435765393250.0322093994679481
DISU vs. CD32.624084391873151.73758896160336e-104.0798155774469e-09
DISU vs. IL7-1.172886499133212.9979797946833e-050.00209234006503939
DISU vs. SAHA0.6645988404007920.2009629776605460.572535545618542
DMSO vs. AZA0.1279039813869610.7109231205520431
DMSO vs. CD31.719427300349333.83318065977356e-062.42125226999953e-05
DMSO vs. DISU-0.913222769957360.00418062518279860.140683473610901
DMSO vs. IL7-0.2463923571435420.4679181818454650.877499426457811
DMSO vs. SAHA1.571848491438980.006914963923812630.0700690746518866
HIV vs. Mock in Activationunknownunknownunknown
HIV vs. Mock in Latency0.4784466803170350.02333226723930930.577521504705005
IL7 vs. CD31.478732685687858.23338315905087e-050.000491103222621186
SAHA vs. CD33.278471603242711.41917838591965e-081.8170788679532e-07
SAHA vs. IL71.826229384291170.0009023070380328460.0107860323277755
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) unknown
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 1.05589 0.248507
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
209839_at 1.82 No downregulated in CD8+ cells

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
3L43 X-ray 2.2Å A/B/C/D=6-306.
5A3F X-ray 3.7Å A/B/C/D=1-764.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Pr55(Gag) co-localizes with 18602423
Pr55(Gag) regulated by 23170932
HIV-1 virus replication enhanced by expression of human gene 25496667

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04072 Phospholipase D signaling pathway - Homo sapiens (human)
hsa04144 Endocytosis - Homo sapiens (human)
hsa04721 Synaptic vesicle cycle - Homo sapiens (human)
hsa04961 Endocrine and other factor-regulated calcium reabsorption - Homo sapiens (human)
hsa05100 Bacterial invasion of epithelial cells - Homo sapiens (human)