Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0008202
UniProt IDP55273
Primary gene name(s)CDKN2D
Synonym gene name(s)unknown
Protein nameCyclin-dependent kinase 4 inhibitor D
Protein functionInteracts strongly with CDK4 and CDK6 and inhibits them. {ECO:0000269|PubMed:7739548, ECO:0000269|PubMed:8741839}.
Subcellular locationNucleus {ECO:0000269|PubMed:9482106}. Cytoplasm {ECO:0000269|PubMed:9482106}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P55273
Gene Ontology
(Biological Process)
Complete annatation
autophagic cell death [GO:0048102];
cell cycle arrest [GO:0007050];
DNA synthesis involved in DNA repair [GO:0000731];
G1/S transition of mitotic cell cycle [GO:0000082];
negative regulation of cell cycle G1/S phase transition [GO:1902807];
negative regulation of cell growth [GO:0030308];
negative regulation of cell proliferation [GO:0008285];
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154];
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902230];
negative regulation of phosphorylation [GO:0042326];
regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079];
response to retinoic acid [GO:0032526];
response to UV [GO:0009411];
response to vitamin D [GO:0033280];
sensory perception of sound [GO:0007605]
Gene Ontology
(Molecular Function)
Complete annatation
cyclin-dependent protein serine/threonine kinase inhibitor activity [GO:0004861];
protein kinase binding [GO:0019901]
Gene Ontology
(Cellular Component)
Complete annatation
cytoplasm [GO:0005737];
cytosol [GO:0005829];
nucleoplasm [GO:0005654];
nucleus [GO:0005634]
Protein-protein interaction107466
Phylogenetic treeP55273
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-2.61673577521981.27279839667871e-071.20047668552825e-06
AZA vs. DISU-0.2908481069643370.2519468566054940.833063742502073
AZA vs. IL7-0.2438730575572570.2077079917967980.971990860091009
AZA vs. SAHA-0.2180727454936960.3732185804179560.740050488169704
DISU vs. CD32.314174205960152.91710251210109e-062.49135429277121e-05
DISU vs. IL70.03707319231131870.8833499105515880.978147487995092
DISU vs. SAHA0.0750249718848890.797217686934210.946755089663451
DMSO vs. AZA-0.03590631141339110.8315917974002761
DMSO vs. CD32.568842936038831.42863465391052e-071.21732924554084e-06
DMSO vs. DISU0.2530443314675870.301366432834470.808227572050797
DMSO vs. IL7-0.2006546527213230.2678136847262640.767539423873874
DMSO vs. SAHA-0.1871538172151420.4289483719134780.765232115661462
HIV vs. Mock in Activation0.3728713221420040.7158579584380880.999983755607037
HIV vs. Mock in Latency0.152084862179950.3587193253529630.999834320637052
IL7 vs. CD32.378211672959768.37588299162917e-078.32781558923657e-06
SAHA vs. CD32.375454302539311.6560383894193e-061.273940711003e-05
SAHA vs. IL70.02385064487384080.9222632086986880.970691813970487
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) unknown
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.303244 0.0212732
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
210240_s_at 1.48 No downregulated in CD8+ cells

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
1BD8 X-ray 1.8Å A=7-162.
1BI8 X-ray 2.8Å B/D=1-166.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04068 FoxO signaling pathway - Homo sapiens (human)
hsa04110 Cell cycle - Homo sapiens (human)