Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0008162
UniProt IDO60503
Primary gene name(s)ADCY9
Synonym gene name(s)KIAA0520
Protein nameAdenylate cyclase type 9
Protein functionAdenylyl cyclase that catalyzes the formation of the signaling molecule cAMP in response to activation of G protein-coupled receptors, PubMed:9628827, PubMed:12972952, PubMed:15879435, PubMed:10987815. Contributes to signaling cascades activated by CRH, corticotropin-releasing factor, corticosteroids and beta-adrenergic receptors, PubMed:9628827. {ECO:0000269|PubMed:10987815, ECO:0000269|PubMed:12972952, ECO:0000269|PubMed:15879435, ECO:0000269|PubMed:9628827}.
Subcellular locationCell membrane {ECO:0000269|PubMed:10987815, ECO:0000269|PubMed:9628827};
Multi-pass membrane protein {ECO:0000305}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: O60503
Gene Ontology
(Biological Process)
Complete annatation
activation of adenylate cyclase activity [GO:0007190];
activation of protein kinase A activity [GO:0034199];
adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880];
adenylate cyclase-activating G-protein coupled receptor signaling pathway [GO:0007189];
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway [GO:0007193];
cAMP biosynthetic process [GO:0006171];
cAMP-mediated signaling [GO:0019933];
cellular response to glucagon stimulus [GO:0071377];
renal water homeostasis [GO:0003091];
signal transduction [GO:0007165]
Gene Ontology
(Molecular Function)
Complete annatation
adenylate cyclase activity [GO:0004016];
ATP binding [GO:0005524];
metal ion binding [GO:0046872]
Gene Ontology
(Cellular Component)
Complete annatation
axon [GO:0030424];
dendrite [GO:0030425];
integral component of membrane [GO:0016021];
integral component of plasma membrane [GO:0005887];
intracellular [GO:0005622];
plasma membrane [GO:0005886]
Protein-protein interaction106628
Phylogenetic treeO60503
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
      unknown
Brass et al., Science, 2008
      unknown
Smith et al., J. Immunol, 2010
      unknown
Interferon-stimulated
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model


DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-1.356104378778227.08097577735156e-050.000354684170542515
AZA vs. DISU-0.00589562107229480.9815466660344690.998432150441561
AZA vs. IL70.3178837459658110.101708883410480.842369160516846
AZA vs. SAHA-0.1135508004011120.6446130470292040.890388361546083
DISU vs. CD31.33929619490880.0003267400240940520.00158089247948578
DISU vs. IL70.3143783562512350.2144800332380730.595069211193378
DISU vs. SAHA-0.105817225759930.7174362087070380.91670039011647
DMSO vs. AZA0.08641871618395630.6109537222151751
DMSO vs. CD31.430268292088511.71151012137161e-059.31835922604382e-05
DMSO vs. DISU0.0902163569132620.7132626570436980.962591472869635
DMSO vs. IL70.2390650140994030.1877225510928590.699129415564804
DMSO vs. SAHA-0.2052928103925270.3874854686187370.734353916097921
HIV vs. Mock in Activation0.3360075230982160.5998029246458560.999983755607037
HIV vs. Mock in Latency-0.0810707438425560.6276495867656880.999834320637052
IL7 vs. CD31.680288248431015.30163236867054e-075.50354715516329e-06
SAHA vs. CD31.219092627949660.0007823254236761780.0028938743580756
SAHA vs. IL7-0.4342295166149710.07666199013627980.243849512410695
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) unknown
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.334771 0.0307652
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category