Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0008111
UniProt IDP24864
Primary gene name(s)CCNE1
Synonym gene name(s)CCNE
Protein nameG1/S-specific cyclin-E1
Protein functionEssential for the control of the cell cycle at the G1/S, start transition. {ECO:0000269|PubMed:7739542}.
Subcellular locationNucleus {ECO:0000269|PubMed:7739542}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P24864
Gene Ontology
(Biological Process)
Complete annatation
androgen receptor signaling pathway [GO:0030521];
cell division [GO:0051301];
DNA replication initiation [GO:0006270];
G1/S transition of mitotic cell cycle [GO:0000082];
positive regulation of transcription, DNA-templated [GO:0045893];
protein phosphorylation [GO:0006468];
regulation of cell cycle [GO:0051726];
regulation of transcription involved in G1/S transition of mitotic cell cycle [GO:0000083];
Wnt signaling pathway [GO:0016055]
Gene Ontology
(Molecular Function)
Complete annatation
androgen receptor binding [GO:0050681];
cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538];
kinase activity [GO:0016301];
transcription coactivator activity [GO:0003713]
Gene Ontology
(Cellular Component)
Complete annatation
centrosome [GO:0005813];
cyclin-dependent protein kinase holoenzyme complex [GO:0000307];
cytosol [GO:0005829];
nucleoplasm [GO:0005654];
nucleus [GO:0005634]
Protein-protein interaction107338
Phylogenetic treeP24864
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD33.539996858669851.07025499573865e-132.97617772984741e-12
AZA vs. DISU0.3580540685300830.2053700874334990.796059535108525
AZA vs. IL70.4398975312236720.2512296826415940.999311006273513
AZA vs. SAHA1.219261434048060.01441571560202610.123960351959465
DISU vs. CD3-3.187751710125939.93438664664836e-123.02527160225409e-10
DISU vs. IL70.06627344029091340.8619627833869130.973704680371504
DISU vs. SAHA0.8619054252289330.06665668471876770.326799900909743
DMSO vs. AZA-0.03634657808247860.8985791209680771
DMSO vs. CD3-3.591917885815787.89368570508486e-142.03627354703944e-12
DMSO vs. DISU-0.3996384627142190.1422448264138520.634022340744381
DMSO vs. IL70.482479592319590.2191427973966080.7275000376027
DMSO vs. SAHA1.25053328549240.01296882215656530.106980360548218
HIV vs. Mock in Activation-0.2129203260498960.81420090422630.999983755607037
HIV vs. Mock in Latency-0.3399788218112910.1005040326853490.999834320637052
IL7 vs. CD3-3.091573736719181.8123115452795e-082.58194441606785e-07
SAHA vs. CD3-2.339016328361120.0003809480394815210.00154657514951146
SAHA vs. IL70.7813630104226090.1874960046248670.417742334406731
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) unknown
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.54959 0.000305467
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
213523_at 1.47 No upregulated in CD8+ cells

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
1W98 X-ray 2.1Å B=96-378.
5L2W X-ray 2.8Å B=96-378.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Envelope surface glycoprotein gp120 downregulates 9453249
Tat activates 9223324
Nef downregulates 15343382
Tat binds 16289656
Tat stimulated by 12114499
Tat downregulates 9525916

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04110 Cell cycle - Homo sapiens (human)
hsa04114 Oocyte meiosis - Homo sapiens (human)
hsa04115 p53 signaling pathway - Homo sapiens (human)
hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
hsa05161 Hepatitis B - Homo sapiens (human)
hsa05162 Measles - Homo sapiens (human)
hsa05200 Pathways in cancer - Homo sapiens (human)
hsa05203 Viral carcinogenesis - Homo sapiens (human)
hsa05206 MicroRNAs in cancer - Homo sapiens (human)
hsa05215 Prostate cancer - Homo sapiens (human)
hsa05222 Small cell lung cancer - Homo sapiens (human)