Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0008102
UniProt IDP13686
Primary gene name(s)ACP5
Synonym gene name(s)unknown
Protein nameTartrate-resistant acid phosphatase type 5
Protein functionInvolved in osteopontin/bone sialoprotein dephosphorylation. Its expression seems to increase in certain pathological states such as Gaucher and Hodgkin diseases, the hairy cell, the B-cell, and the T-cell leukemias.
Subcellular locationLysosome.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P13686
Gene Ontology
(Biological Process)
Complete annatation
bone morphogenesis [GO:0060349];
bone resorption [GO:0045453];
defense response to Gram-positive bacterium [GO:0050830];
negative regulation of inflammatory response [GO:0050728];
negative regulation of interleukin-12 production [GO:0032695];
negative regulation of interleukin-1 beta production [GO:0032691];
negative regulation of nitric oxide biosynthetic process [GO:0045019];
negative regulation of superoxide anion generation [GO:0032929];
negative regulation of tumor necrosis factor production [GO:0032720];
response to cytokine [GO:0034097];
response to lipopolysaccharide [GO:0032496];
riboflavin metabolic process [GO:0006771]
Gene Ontology
(Molecular Function)
Complete annatation
acid phosphatase activity [GO:0003993];
ferric iron binding [GO:0008199];
ferrous iron binding [GO:0008198]
Gene Ontology
(Cellular Component)
Complete annatation
cytosol [GO:0005829];
extracellular exosome [GO:0070062];
extracellular space [GO:0005615];
integral component of membrane [GO:0016021];
lysosome [GO:0005764]
Protein-protein interaction106570
Phylogenetic treeP13686
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-2.980817868595451.11022302462516e-164.55947722810636e-15
AZA vs. DISU-0.5342728665386050.07099447653498270.578440651595245
AZA vs. IL7-0.1918352038590440.3633245600154380.999311006273513
AZA vs. SAHA-0.5385747426792350.03059284257884620.201691278847615
DISU vs. CD32.436240972937973.56633944598173e-107.9525149125338e-09
DISU vs. IL70.3314707296336680.2538764224387910.639783862966362
DISU vs. SAHA-0.001858137560997930.9949878522269040.999572425883731
DMSO vs. AZA-0.02461589362778260.8868079164134241
DMSO vs. CD32.9441015107336500
DMSO vs. DISU0.507143585169060.05348622126371050.451060929556543
DMSO vs. IL7-0.1597378731496650.386940216249890.838092494248146
DMSO vs. SAHA-0.5182247305810110.03117447589523970.188990557609476
HIV vs. Mock in Activation0.03186052284369780.9608962124134160.999983755607037
HIV vs. Mock in Latency0.02271726598523320.8926076912503040.999834320637052
IL7 vs. CD32.793131022618921.55431223447522e-156.65572395177414e-14
SAHA vs. CD32.419228057594091.82868054032781e-103.6891855077296e-09
SAHA vs. IL7-0.3481262319463860.16066083312470.381205949712219
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
0.4899 0.02062

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) unknown
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.0217148 0.917482
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
204638_at 1.59 No upregulated in CD8+ cells

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

Drugbank ID Drug Name Drug Status Pharmacological Action Drug Action
DB02325 Isopropyl Alcohol approved unknown unknown

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
1WAR X-ray 2.2Å A=22-325.
2BQ8 X-ray 2.2Å X=22-325.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Envelope transmembrane glycoprotein gp41 downregulates 23383108

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04142 Lysosome - Homo sapiens (human)
hsa04380 Osteoclast differentiation - Homo sapiens (human)
hsa05323 Rheumatoid arthritis - Homo sapiens (human)