Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0008086
UniProt IDQ9UQV4
Primary gene name(s)LAMP3
Synonym gene name(s)DCLAMP, TSC403
Protein nameLysosome-associated membrane glycoprotein 3
Protein functionMay play a role in dendritic cell function and in adaptive immunity. {ECO:0000269|PubMed:9768752}.
Subcellular locationLysosome membrane {ECO:0000269|PubMed:21930964, ECO:0000269|PubMed:9768752};
Single-pass type I membrane protein {ECO:0000255}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:9768752};
Single-pass type I membrane protein {ECO:0000255}. Note=During dendritic cell maturation, detected on cytoplasmic vesicles, the MHC II compartment that contain MHC II proteins, LAMP1, LAMP2 and LAMP3, PubMed:9768752. Detected on lysosomes in mature dendritic cells, PubMed:9768752. {ECO:0000269|PubMed:9768752}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q9UQV4
Gene Ontology
(Biological Process)
Complete annatation
adaptive immune response [GO:0002250];
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154];
negative regulation of proteasomal protein catabolic process [GO:1901799];
positive regulation of gene expression [GO:0010628];
regulation of autophagy [GO:0010506];
regulation of viral life cycle [GO:1903900];
response to interferon-alpha [GO:0035455]
Gene Ontology
(Molecular Function)
Complete annatation
Gene Ontology
(Cellular Component)
Complete annatation
alveolar lamellar body membrane [GO:0097233];
early endosome [GO:0005769];
integral component of membrane [GO:0016021];
lysosomal membrane [GO:0005765];
perinuclear region of cytoplasm [GO:0048471];
plasma membrane [GO:0005886];
vesicle [GO:0031982]
Protein-protein interaction117983
Phylogenetic treeQ9UQV4
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD36.352410842351842.09843253884401e-103.45279205518088e-09
AZA vs. DISUunknownunknownunknown
AZA vs. IL7unknownunknownunknown
AZA vs. SAHAunknownunknownunknown
DISU vs. CD3-6.26454438784111.41816525189853e-092.73718604444538e-08
DISU vs. IL7unknownunknownunknown
DISU vs. SAHAunknownunknownunknown
DMSO vs. AZAunknownunknownunknown
DMSO vs. CD3-7.108371835248636.90147605730829e-109.20095015958844e-09
DMSO vs. DISUunknownunknownunknown
DMSO vs. IL7unknownunknownunknown
DMSO vs. SAHAunknownunknownunknown
HIV vs. Mock in Activation0.2005112078419480.9029013652024880.999983755607037
HIV vs. Mock in Latencyunknownunknownunknown
IL7 vs. CD3-5.566574325840961.69177704290036e-071.97675623004938e-06
SAHA vs. CD3-6.549934495701357.14557746306355e-101.21952267687846e-08
SAHA vs. IL7unknownunknownunknown
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock 1.25 1.41E-05 2.37E-04