Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0008062
UniProt IDP51681
Primary gene name(s)CCR5
Synonym gene name(s)CMKBR5
Protein nameC-C chemokine receptor type 5
Protein functionReceptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Acts as a coreceptor, CD4 being the primary receptor for HIV-1 R5 isolates. {ECO:0000269|PubMed:11323418, ECO:0000269|PubMed:8639485, ECO:0000269|PubMed:8649511, ECO:0000269|PubMed:8649512, ECO:0000269|PubMed:8663314, ECO:0000269|PubMed:8699119}.; FUNCTION:, Microbial infection Acts as a receptor for human immunodeficiency virus-1/HIV-1. {ECO:0000269|PubMed:21763489, ECO:0000269|PubMed:9632396}.
Subcellular locationCell membrane {ECO:0000269|PubMed:11323418};
Multi-pass membrane protein {ECO:0000269|PubMed:11323418}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P51681
Gene Ontology
(Biological Process)
Complete annatation
calcium ion transport [GO:0006816];
calcium-mediated signaling [GO:0019722];
cell-cell signaling [GO:0007267];
cell surface receptor signaling pathway [GO:0007166];
cellular defense response [GO:0006968];
cellular response to lipopolysaccharide [GO:0071222];
chemotaxis [GO:0006935];
dendritic cell chemotaxis [GO:0002407];
entry into host cell [GO:0030260];
fusion of virus membrane with host plasma membrane [GO:0019064];
G-protein coupled receptor signaling pathway [GO:0007186];
immune response [GO:0006955];
inflammatory response [GO:0006954];
MAPK cascade [GO:0000165];
positive regulation of cytosolic calcium ion concentration [GO:0007204];
release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0014808];
response to cholesterol [GO:0070723];
signaling [GO:0023052]
Gene Ontology
(Molecular Function)
Complete annatation
actin binding [GO:0003779];
C-C chemokine binding [GO:0019957];
C-C chemokine receptor activity [GO:0016493];
chemokine, C-C motif ligand 5 binding [GO:0071791];
chemokine receptor activity [GO:0004950];
coreceptor activity [GO:0015026];
phosphatidylinositol phospholipase C activity [GO:0004435];
virus receptor activity [GO:0001618]
Gene Ontology
(Cellular Component)
Complete annatation
cell surface [GO:0009986];
cytoplasm [GO:0005737];
endosome [GO:0005768];
external side of plasma membrane [GO:0009897];
integral component of plasma membrane [GO:0005887];
plasma membrane [GO:0005886]
Protein-protein interaction107639
Phylogenetic treeP51681
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
      unknown
Brass et al., Science, 2008
      unknown
Smith et al., J. Immunol, 2010
      unknown
Interferon-stimulated
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model


DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-1.588632173675030.002497309151857640.00804089799974329
AZA vs. DISU-1.313026981491310.1204520519808930.679018037232606
AZA vs. IL70.5431257136048510.02836208880512270.538415320604048
AZA vs. SAHA0.4875495031021730.2013947110257610.568719346946857
DISU vs. CD30.2672600772289960.7595893604454630.8332427751342
DISU vs. IL71.844960403106930.02625766196179670.206918062767426
DISU vs. SAHA1.803846946852210.04972363558685730.278789029735687
DMSO vs. AZA0.0607123381005490.8579813741152191
DMSO vs. CD31.647816907053880.00358218571310720.0103568212811179
DMSO vs. DISU1.374337290675710.1112557867696360.586319898851999
DMSO vs. IL70.4882309863473520.1132471668712580.600951753185431
DMSO vs. SAHA0.4201057662813370.3225791201422480.676012750171312
HIV vs. Mock in Activation0.2904630369503320.7828765649302620.999983755607037
HIV vs. Mock in Latency0.1151616570311890.7996077012035750.999834320637052
IL7 vs. CD32.135141264086832.06966952503995e-050.000146874429147492
SAHA vs. CD32.055594840080180.0005702086713609280.0021915441666435
SAHA vs. IL7-0.05454930597494670.8761904649822570.950330628086238
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
2.7 0.000115301 1.9 0.002905687 2.3 0.002972792
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) unknown
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.0593272 0.741784
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
206991_s_at 2.35 Yes upregulated in CD4+ cells
206991_s_at 3.06 Yes upregulated in CD8+ cells

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

Drugbank ID Drug Name Drug Status Pharmacological Action Drug Action
DB04835 Maraviroc approved, investigational yes antagonist
DB05062 INCB9471 investigational unknown unknown
DB05501 AMD-070 investigational unknown unknown

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
1ND8 Model - A=1-352.
1NE0 Model - A=1-352.
1OPN Model - A=1-352.
1OPT Model - A=1-352.
1OPW Model - A=1-352.
2L87 NMR - A=1-27.
2MZX NMR - A=186-195.
2RLL NMR - A=7-15.
2RRS NMR - A=157-174.
4MBS X-ray 2.7Å A/B=2-352.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Envelope surface glycoprotein gp120 induces rearrangement of 23575248
Envelope surface glycoprotein gp120 interacts with 10758170
12857973
1296023111023526
11278567
11356952
11390601
11529558
11679153
11689632
11709091
11711617
12368322
15767436
17722977
17971448
17977968
18815295
19339951
19625411
20923564
21288812
21288824
21295814
21513481
21525208
21569409
21676905
22876913
23446039
23672855
24676404
24859049
2531368915972662
16375941
16943294
17255952
2204422516963439
17207111
18480458
21325401
21345957
21573951
21763489
21859712
22028271
22292949
22313935
22876913
23808984
2409004123077246
23606583
24149829
24478426
24957778
25008924
25231990
25313689
25703038
26114311
9184207
9261451
9632396
9653051
9870313
9971818
10200301
10357469
10482572
10544150
10562492
11069996
11153675
11861850
12163614
12202222
12368322
12408990
12490404
12610158
15857992
15890935
15964018
15983047
16378977
16476981
16721558
16966601
17101166
17202224
17328229
17329448
17411375
17507467
17582634
18036244
18160142
18480460
18753930
18815295
19625411
20377425
20381825
20921899
21288812
21288824
21513481
21555814
21760891
21835796
21994672
22047989
22157596
22286874
22292949
22313935
22424737
22657741
22728273
22732432
22830600
22876913
22954962
23297034
23369572
23446039
23596523
23606583
23672855
23745959
23758814
23808984
24215935
24763408
24859049
24862329
25265194
25313689
Tat upregulates 10602409
9765440
10453044
15586413
15629079
16179731
19864932
23842123
Envelope transmembrane glycoprotein gp41 downregulates 25265071
Envelope surface glycoprotein gp120 inhibits 9653130
11413305
11414813
21188555
Vpr interacts with 24339781
Envelope surface glycoprotein gp160; precursor interacts with 23606583
Nef downregulates 15854903
15854903
18462992
19149577
20594957
22103833
22103834
22175768
2448982520465832
21696586
22808111
25807049
Envelope surface glycoprotein gp120 upregulates 23742646
Envelope surface glycoprotein gp120 binds 10089882
10497246
12169668
1218346210339592
10438870
10482561
11238869
1750748610477718
10725362
18691022
21680525
2570020411336643
11468147
11698270
12857973
1296023116631222
17210123
18453587
18590744
22028271
25797607
26081316
8674119
8805353
8898753
8906795
8906796
8976200
8995603
9020356
9031325
9184207
9188565
9261346
9261451
9334377
9353123
9359702
9362541
9420225
9420238
9445013
9525683
9576751
9576954
9632396
9636210
9653051
9870313
9882290
9882373
9890944
9971818
10029247
10089882
10200301
10229873
10339592
10357469
10370370
10393974
10413516
10438870
10446313
10449282
10477718
10482572
10487781
10497246
10505675
10527688
10544150
10555208
10559284
10562492
10574939
10585143
10590105
10590121
10602038
10606089
10623731
10644351
10725362
10738970
10775626
10816381
10820198
10823934
10826481
10877489
10882583
10888615
10888639
10938094
10961858
10970739
11005830
11023526
11024154
11069996
11086073
11115360
11118070
11134270
11162839
11238869
11263244
11264346
11264367
11265761
11290759
11312658
11313374
11336643
11342415
11356961
11356967
11397808
11413305
11414813
11427892
11429110
11464139
11468147
11485305
11489906
11517394
11529558
11596075
11602715
11679153
11689632
11698270
11709091
11861850
11861874
11876757
11877445
11878912
11884536
11906183
11967288
12120995
12163558
12163614
12169668
12183462
12190962
12202222
12368322
12392548
12408990
12429712
12429730
12441808
12477875
12610158
12634405
12692222
12845769
12857973
12871111
12873764
12873765
12887918
12960231
12963807
14512572
14517611
14585219
14592765
14967033
14990703
15018709
15045488
15113926
15194768
15215692
15258189
15279544
15279586
15321703
15767436
15784911
15807900
15857992
15890935
15956589
15964018
15972662
15983047
16002156
16157597
16282475
16300985
16309726
16314403
16375941
16386774
16437164
16470129
16515489
16672549
16685256
16686527
16702010
16712896
16721558
16753228
16775320
16796521
16817962
16855325
16934308
16943294
16966601
17010165
17030448
17035237
17041228
17053352
17101166
17116673
17121788
17147503
17151939
17174449
17187670
17201668
17306322
17328229
17346133
17411375
17485501
17507467
17507486
17920626
17933717
17933721
17936869
17947541
17959679
17971448
17977968
18036244
18076768
18090388
18160142
18197116
18203956
18242797
18296630
18453587
18468560
18480460
18490657
18500445
18577234
18588983
18590744
18614865
18619974
18624812
18672260
18691022
18786994
18799178
18925934
18958626
18976462
18977142
18991615
19020816
19020832
19055831
19129457
19144136
19170639
19180188
19279116
19339951
19339953
19401538
19402700
19556424
19625411
19661992
19692476
19692480
19695656
19776131
19837465
20007245
20015684
20041213
20051874
20229778
20299967
20377425
20381825
20494390
20507591
20530226
20622876
20639728
20657663
20678176
20698725
20797755
20810746
20842205
20854195
20856130
20861743
20921899
20923564
20942936
20947116
20969781
20981786
21106747
21118814
21128884
21152581
21165786
21188555
21226626
21248683
21284403
21284899
21284900
21284902
21284906
21284907
21288812
21288824
21295814
21310296
21325401
21330910
21345957
21346189
21349294
21351426
21356539
21362450
21373976
21388649
21555814
21569409
21647388
21663455
21676905
21680525
21760891
21763507
21835796
21859712
21875413
21914280
21926353
21948112
21994458
21994672
22024519
22047989
22069466
22101471
22124968
22147793
22147802
22157596
22219640
22286875
22291694
22297516
22313935
22332354
22447925
22470838
22474613
22520838
22547820
22650962
22657741
22811524
22818780
22842622
22908191
22954962
23043103
23043104
23077246
23135721
23143844
23153179
23202514
23229639
23269796
23330719
23350534
23355876
23389465
23446039
23449229
23602007
23606583
23672855
23692808
23696662
23762317
23774428
23884589
24030490
24041034
24149829
24156625
24158961
24215935
24307580
24309114
24312095
24312168
24381033
24387762
24390333
24454812
24461764
24465884
24478426
24586501
24606688
24635642
24657436
24731927
24788065
24862329
24897520
24931198
24957778
24990163
25081935
25193376
25231990
25313689
25387392
25595802
25724219
25730507
25809903
25840914
258801108898753
8976200
9031325
9359702
9420238
9576751
9653051
10393974
10644351
10775626
10820198
10882583
11162839
11313374
11427892
11877445
12689409
12692222
12871111
12873764
12873765
12963807
14990703
15279544
15992849
17053352
17328229
18242797
18588983
18706447
18786994
19129457
19339953
19722264
20018238
20570309
20842205
21188555
21388649
21647388
22286874
22403408
22787219
23229639
23692808
257856109362541
11698270
12857973
129602319420225
9445013
9525683
9653051
9882373
9890944
10574939
10823934
10938094
11356961
12183462
22024519
257030389632396
10602038
10801487
10826481
10888615
10970739
11278567
15113926
16157597
17901336
17971448
18952441
19692476
20856130
20923564
20969781
21152581
21248683
21284403
22403408
24859049
Envelope transmembrane glycoprotein gp41 induces phosphorylation of 10872839
Tat downregulates 10751368
16179731
Envelope surface glycoprotein gp120 regulated by 24778234
matrix downregulates 25265071
matrix increases 26347747
Envelope transmembrane glycoprotein gp41 complexes with 12871111
14505910
14694113
15047829
15258189
15308751
15479838
17686153
18353949
18468560
18500445
18925934
18977142
18991615
20570309
21356539
21760891
21926353
22069466
22297516
22732432
23043103
23043104
23541872
24041034
24371049
24381033
2523199018925934
21926353
Envelope surface glycoprotein gp120 downregulates 10438703
1134241518462992
Envelope transmembrane glycoprotein gp41 interacts with 21859712
25231990
9256481
capsid downregulates 25265071
Envelope surface glycoprotein gp120 associates with 19402700
HIV-1 virus replication enhanced by expression of human gene 22404213
2535825124831610
Envelope surface glycoprotein gp120 mediated by 12551992
12960231
2084220516841089
2084220517121788
208422059184207
9188565
9334377
11414813
12873764
15258189
16300985
16702010
17686153
18673537
20381825
22908191
capsid interacts with 25840914
Envelope surface glycoprotein gp120 complexes with 11069996
11134270
11264346
15321703
17147503
17346133
17507486
18205925
18296630
18490657
18590744
18691022
21152581
21330910
21349294
21680525
21760891
2199467217030448
17901336
18952441
2496369418076768
21926353
22403408
9261346
9334377
11264346
12477875
12887918
16672549
16702010
16817962
16999983
17053352
17306322
17346133
17507486
17722977
18076768
18490657
18619974
18691022
18815295
20018238
20507591
21152581
21325401
21760891
21994672
22547820
23692808
24172894
24172896
24172905
24243013
24409525
25700204
25888743
Envelope surface glycoprotein gp120 inhibited by 16841089
2084220524778234
24778234
24778234
capsid increases 26347747
Envelope surface glycoprotein gp120 activates 16621960
18453587
24086760
9353123
12857973
12960231
20842205
Envelope transmembrane glycoprotein gp41 increases 26347747
Envelope transmembrane glycoprotein gp41 modulates 18353956
Envelope transmembrane glycoprotein gp41 upregulates 10807185

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human)
hsa04062 Chemokine signaling pathway - Homo sapiens (human)
hsa04144 Endocytosis - Homo sapiens (human)
hsa05145 Toxoplasmosis - Homo sapiens (human)
hsa05203 Viral carcinogenesis - Homo sapiens (human)
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