Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0007837
UniProt IDQ9H9H4
Primary gene name(s)VPS37B
Synonym gene name(s)unknown
Protein nameVacuolar protein sorting-associated protein 37B
Protein functionComponent of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation. {ECO:0000269|PubMed:15218037}.
Subcellular locationLate endosome membrane {ECO:0000269|PubMed:15218037};
Peripheral membrane protein {ECO:0000269|PubMed:15218037}. Note=Recruited to the endosomal membrane in a VPS4A-dependent fashion.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q9H9H4
Gene Ontology
(Biological Process)
Complete annatation
autophagy [GO:0006914];
endosomal transport [GO:0016197];
intracellular transport of virus [GO:0075733];
multivesicular body assembly [GO:0036258];
positive regulation of viral budding via host ESCRT complex [GO:1903774];
positive regulation of viral release from host cell [GO:1902188];
protein transport [GO:0015031];
viral budding via host ESCRT complex [GO:0039702];
viral life cycle [GO:0019058]
Gene Ontology
(Molecular Function)
Complete annatation
calcium-dependent protein binding [GO:0048306]
Gene Ontology
(Cellular Component)
Complete annatation
cytoplasm [GO:0005737];
endosome [GO:0005768];
endosome membrane [GO:0010008];
ESCRT I complex [GO:0000813];
extracellular exosome [GO:0070062];
late endosome membrane [GO:0031902];
midbody [GO:0030496];
plasma membrane [GO:0005886]
Protein-protein interaction122836
Phylogenetic treeQ9H9H4
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
      unknown
Brass et al., Science, 2008
      unknown
Smith et al., J. Immunol, 2010
      unknown
Interferon-stimulated
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model


DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-0.9812855720049690.003042220378002170.00952588634950118
AZA vs. DISU0.001100203158245040.9965378547232360.999297613676408
AZA vs. IL7-0.1118077325374390.5635459957404430.999311006273513
AZA vs. SAHA-0.4292386678700580.08025354278695770.352797288996967
DISU vs. CD30.9701460243348730.008053544372708550.0242168617343325
DISU vs. IL7-0.1229445987135650.6265136716211910.887542218267293
DISU vs. SAHA-0.427522315544090.1438073117179570.487462703483221
DMSO vs. AZA-0.09627803223206320.5688254685656841
DMSO vs. CD30.8754761052715830.006683455297654350.017584047163668
DMSO vs. DISU-0.09877042546858770.686356906125650.957954410639349
DMSO vs. IL7-0.008375026331638260.96310434692850.993151606293804
DMSO vs. SAHA-0.3382852491151980.1534729459394510.472810868408314
HIV vs. Mock in Activation0.3860501832546710.5371986163005640.999983755607037
HIV vs. Mock in Latency0.105415325682580.5268464859191810.999834320637052
IL7 vs. CD30.8741177528365170.007079139527621070.0224403512302487
SAHA vs. CD30.5293609765256070.1358670884238270.222483649086937
SAHA vs. IL7-0.3193433338830620.1923222970145010.42285097800417
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) unknown
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.524833 0.000305467
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
0.966 0.824 0.746 0.709 0.874
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
p6 complexes with 18005716
23895345
p6 binds 23895345
nucleocapsid binds 23895345
Pr55(Gag) regulated by 15218037
21762798
22004035
23027949
23305486
nucleocapsid complexes with 18005716
23895345

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04144 Endocytosis - Homo sapiens (human)
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