Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0007821
UniProt IDQ9BQE4
Primary gene name(s)VIMP
Synonym gene name(s)SELS
Protein nameSelenoprotein S
Protein functionInvolved in the degradation process of misfolded endoplasmic reticulum, ER luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination. {ECO:0000269|PubMed:15215856}.
Subcellular locationEndoplasmic reticulum membrane;
Single-pass membrane protein. Cytoplasm {ECO:0000250}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q9BQE4
Gene Ontology
(Biological Process)
Complete annatation
cell redox homeostasis [GO:0045454];
cellular response to insulin stimulus [GO:0032869];
cellular response to lipopolysaccharide [GO:0071222];
cellular response to oxidative stress [GO:0034599];
endoplasmic reticulum unfolded protein response [GO:0030968];
ER-associated ubiquitin-dependent protein catabolic process [GO:0030433];
ER overload response [GO:0006983];
establishment of protein localization [GO:0045184];
negative regulation of acute inflammatory response to antigenic stimulus [GO:0002865];
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236];
negative regulation of glucose import [GO:0046325];
negative regulation of glycogen biosynthetic process [GO:0045719];
negative regulation of inflammatory response [GO:0050728];
negative regulation of interleukin-6 production [GO:0032715];
negative regulation of macrophage apoptotic process [GO:2000110];
negative regulation of nitric-oxide synthase biosynthetic process [GO:0051771];
negative regulation of tumor necrosis factor production [GO:0032720];
regulation of gluconeogenesis [GO:0006111];
regulation of nitric oxide metabolic process [GO:0080164];
response to glucose [GO:0009749];
response to redox state [GO:0051775];
retrograde protein transport, ER to cytosol [GO:0030970]
Gene Ontology
(Molecular Function)
Complete annatation
antioxidant activity [GO:0016209];
ATPase binding [GO:0051117];
enzyme binding [GO:0019899];
receptor activity [GO:0004872];
ubiquitin-specific protease binding [GO:1990381]
Gene Ontology
(Cellular Component)
Complete annatation
cytoplasmic microtubule [GO:0005881];
Derlin-1 retrotranslocation complex [GO:0036513];
Derlin-1-VIMP complex [GO:0036502];
endoplasmic reticulum [GO:0005783];
integral component of endoplasmic reticulum membrane [GO:0030176];
low-density lipoprotein particle [GO:0034362];
plasma membrane [GO:0005886];
very-low-density lipoprotein particle [GO:0034361]
Protein-protein interaction120934
Phylogenetic treeQ9BQE4
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD30.4524521886019460.1681142467386490.266653786179407
AZA vs. DISU0.0712512105876240.7793506519176330.976444104025318
AZA vs. IL7-0.002923699730563430.9879713866484650.999311006273513
AZA vs. SAHA-0.2918721186833480.2340299645728110.605521401642731
DISU vs. CD3-0.3932603739525120.27937689189310.408708003532278
DISU vs. IL7-0.0832271002317240.7440900763180910.937497526159233
DISU vs. SAHA-0.3614903061313610.217998443309730.593042335581396
DMSO vs. AZA-0.07470336820044820.6587498137219681
DMSO vs. CD3-0.5387331432609610.09310095182399510.161158892247327
DMSO vs. DISU-0.1477188669094220.5471250384455040.922519421573773
DMSO vs. IL70.0791209982696090.6628559464738680.930888829953308
DMSO vs. SAHA-0.2233517941996970.3458411954235510.696918882697836
HIV vs. Mock in Activation-0.1787291139278030.7739996642544570.999983755607037
HIV vs. Mock in Latency-0.05065207228716740.7602742014862490.999834320637052
IL7 vs. CD3-0.4480262144505460.1652595080559070.279631406031285
SAHA vs. CD3-0.7685990688877930.0306649247431680.0660133564967491
SAHA vs. IL7-0.2917888823547810.233559731438260.474035679334196
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) unknown
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.327917 0.0140372
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
1.008 0.967 0.798 0.706 1.054
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
2Q2F X-ray 1.5Å A=52-122.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04141 Protein processing in endoplasmic reticulum - Homo sapiens (human)