Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0007817
UniProt IDP45880
Primary gene name(s)VDAC2
Synonym gene name(s)unknown
Protein nameVoltage-dependent anion-selective channel protein 2
Protein functionForms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective.
Subcellular locationMitochondrion outer membrane {ECO:0000269|PubMed:7539795}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P45880
Gene Ontology
(Biological Process)
Complete annatation
anion transport [GO:0006820];
negative regulation of intrinsic apoptotic signaling pathway [GO:2001243];
negative regulation of protein polymerization [GO:0032272]
Gene Ontology
(Molecular Function)
Complete annatation
nucleotide binding [GO:0000166];
porin activity [GO:0015288];
voltage-gated anion channel activity [GO:0008308]
Gene Ontology
(Cellular Component)
Complete annatation
extracellular exosome [GO:0070062];
membrane raft [GO:0045121];
mitochondrial inner membrane [GO:0005743];
mitochondrial nucleoid [GO:0042645];
mitochondrial outer membrane [GO:0005741];
mitochondrion [GO:0005739];
myelin sheath [GO:0043209];
nucleus [GO:0005634];
pore complex [GO:0046930];
synaptic vesicle [GO:0008021]
Protein-protein interaction113260
Phylogenetic treeP45880
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD31.066383164539690.001280941466330730.0045120968919694
AZA vs. DISU0.09734290838504480.7017892437853810.970369120483745
AZA vs. IL70.1846312885954830.3378543764284460.999311006273513
AZA vs. SAHA-0.01413977062857910.9538215972355270.990329939023704
DISU vs. CD3-0.9812362438116970.007293436095575760.0222823785376386
DISU vs. IL70.078261067860610.7567538732412840.941786906610111
DISU vs. SAHA-0.1103849685509740.7066124566557830.912981856919095
DMSO vs. AZA-0.09232736386160770.5828458370981991
DMSO vs. CD3-1.169211795038310.0003065485519760940.00120989099699236
DMSO vs. DISU-0.191321964346110.4349455348620470.882079719512261
DMSO vs. IL70.2841329918385840.1149964542036940.603561174685793
DMSO vs. SAHA0.07108817379984540.7632969908484320.931825079317738
HIV vs. Mock in Activation-0.07126775318287410.9087921630571420.999983755607037
HIV vs. Mock in Latency-0.06080619120606050.713100511166810.999834320637052
IL7 vs. CD3-0.8737966342960730.006889232976390990.0219306037282242
SAHA vs. CD3-1.105613873048150.002009591456883840.00648908147744579
SAHA vs. IL7-0.2022511093547250.4069760739035640.653172432335034
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) unknown
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -0.0355414 0.851816
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
1.031 0.92 1.055 1.046 0.85
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

Drugbank ID Drug Name Drug Status Pharmacological Action Drug Action
DB01375 Aluminium monostearate approved unknown inhibitor
DB06098 PRLX 93936 investigational unknown unknown

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Vpr interacts with 17254575
Envelope surface glycoprotein gp160; precursor interacts with 22190034
Vpr downregulates 23874603
Envelope transmembrane glycoprotein gp41 interacts with 22190034

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04020 Calcium signaling pathway - Homo sapiens (human)
hsa04022 cGMP-PKG signaling pathway - Homo sapiens (human)
hsa04621 NOD-like receptor signaling pathway - Homo sapiens (human)
hsa05012 Parkinson's disease - Homo sapiens (human)
hsa05016 Huntington's disease - Homo sapiens (human)
hsa05166 HTLV-I infection - Homo sapiens (human)