Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0007352
UniProt IDQ9NYJ8
Primary gene name(s)TAB2
Synonym gene name(s)KIAA0733, MAP3K7IP2
Protein nameTGF-beta-activated kinase 1 and MAP3K7-binding protein 2
Protein functionAdapter linking MAP3K7/TAK1 and TRAF6. Promotes MAP3K7 activation in the IL1 signaling pathway. The binding of 'Lys-63'-linked polyubiquitin chains to TAB2 promotes autophosphorylation of MAP3K7 at 'Thr-187'. Involved in heart development. {ECO:0000269|PubMed:10882101, ECO:0000269|PubMed:11460167, ECO:0000269|PubMed:20493459}.
Subcellular locationMembrane {ECO:0000269|PubMed:10882101};
Peripheral membrane protein {ECO:0000269|PubMed:10882101}. Cytoplasm, cytosol {ECO:0000269|PubMed:10882101}. Note=Following IL1 stimulation, translocation occurs from the membrane to cytosol.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q9NYJ8
Gene Ontology
(Biological Process)
Complete annatation
activation of MAPK activity [GO:0000187];
Fc-epsilon receptor signaling pathway [GO:0038095];
heart development [GO:0007507];
I-kappaB kinase/NF-kappaB signaling [GO:0007249];
JNK cascade [GO:0007254];
MyD88-dependent toll-like receptor signaling pathway [GO:0002755];
negative regulation of autophagy [GO:0010507];
nucleotide-binding oligomerization domain containing signaling pathway [GO:0070423];
positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123];
positive regulation of NF-kappaB transcription factor activity [GO:0051092];
positive regulation of protein kinase activity [GO:0045860];
stimulatory C-type lectin receptor signaling pathway [GO:0002223];
T cell receptor signaling pathway [GO:0050852]
Gene Ontology
(Molecular Function)
Complete annatation
K63-linked polyubiquitin binding [GO:0070530];
zinc ion binding [GO:0008270]
Gene Ontology
(Cellular Component)
Complete annatation
cytosol [GO:0005829];
endosome membrane [GO:0010008];
plasma membrane [GO:0005886]
Protein-protein interaction116740
Phylogenetic treeQ9NYJ8
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
      unknown
Brass et al., Science, 2008
      unknown
Smith et al., J. Immunol, 2010
      unknown
Interferon-stimulated
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model


DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-0.009280660338906150.9773834892118840.984766625402869
AZA vs. DISU0.05094330821734830.8401674543922710.986800805932004
AZA vs. IL70.3771453304503030.04930100879217750.647888930452026
AZA vs. SAHA0.01813908720559650.9406545536757980.987425260592548
DISU vs. CD30.04767154012536170.89580312791230.931778660650705
DISU vs. IL70.3171879790977170.2074197349087050.586321489545983
DISU vs. SAHA-0.0314939335717690.9137325210328340.98055132615251
DMSO vs. AZA-0.08423441327142190.6135235155504721
DMSO vs. CD3-0.08527558082748050.789719553111660.851558590482224
DMSO vs. DISU-0.1367706777414970.5745792726142640.931469777531738
DMSO vs. IL70.4685163974296150.009060970813922320.197962514521564
DMSO vs. SAHA0.09536388906620120.6854488807140680.901903272327721
HIV vs. Mock in Activation0.1324084940021630.8315737804444710.999983755607037
HIV vs. Mock in Latency0.03177076840000180.8550755129392120.999834320637052
IL7 vs. CD30.3941842713617350.2211798713246180.348264598973826
SAHA vs. CD30.002782579800650920.9937461974724540.995643947202836
SAHA vs. IL7-0.3625264453464550.1361655619674780.345898159942326
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
-1.8 0.005169481 -1.3 0.076871826 -1.9 0.054991985
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) unknown
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -0.355785 0.00622456
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
1.166 1.173 1.224 1.342 0.956
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
2DAE NMR - A=7-68.
2WWZ X-ray 1.4Å C=662-693.
2WX0 X-ray 2.4Å C/G=663-693.
2WX1 X-ray 3.0Å C=663-693.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Envelope surface glycoprotein gp120 interacts with 22190034
Tat upregulates 25943894
capsid inhibited by 21512569
21512573
21572451
21575904
21866272
HIV-1 virus replication enhanced by expression of human gene 19460752

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04010 MAPK signaling pathway - Homo sapiens (human)
hsa04064 NF-kappa B signaling pathway - Homo sapiens (human)
hsa04380 Osteoclast differentiation - Homo sapiens (human)
hsa04620 Toll-like receptor signaling pathway - Homo sapiens (human)
hsa04621 NOD-like receptor signaling pathway - Homo sapiens (human)
hsa04657 IL-17 signaling pathway - Homo sapiens (human)
hsa04668 TNF signaling pathway - Homo sapiens (human)
hsa05140 Leishmaniasis - Homo sapiens (human)
hsa05145 Toxoplasmosis - Homo sapiens (human)
hsa05162 Measles - Homo sapiens (human)
hsa05168 Herpes simplex infection - Homo sapiens (human)
hsa05169 Epstein-Barr virus infection - Homo sapiens (human)
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