Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0007351
UniProt IDQ15750
Primary gene name(s)TAB1
Synonym gene name(s)MAP3K7IP1
Protein nameTGF-beta-activated kinase 1 and MAP3K7-binding protein 1
Protein functionMay be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis.
Subcellular locationunknown
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q15750
Gene Ontology
(Biological Process)
Complete annatation
activation of MAPK activity [GO:0000187];
activation of MAPKKK activity [GO:0000185];
aorta development [GO:0035904];
cardiac septum development [GO:0003279];
coronary vasculature development [GO:0060976];
Fc-epsilon receptor signaling pathway [GO:0038095];
heart morphogenesis [GO:0003007];
I-kappaB kinase/NF-kappaB signaling [GO:0007249];
in utero embryonic development [GO:0001701];
JNK cascade [GO:0007254];
lung development [GO:0030324];
MyD88-dependent toll-like receptor signaling pathway [GO:0002755];
nucleotide-binding oligomerization domain containing signaling pathway [GO:0070423];
positive regulation of NF-kappaB transcription factor activity [GO:0051092];
stimulatory C-type lectin receptor signaling pathway [GO:0002223];
transforming growth factor beta receptor signaling pathway [GO:0007179]
Gene Ontology
(Molecular Function)
Complete annatation
enzyme activator activity [GO:0008047];
kinase activator activity [GO:0019209];
protein serine/threonine phosphatase activity [GO:0004722]
Gene Ontology
(Cellular Component)
Complete annatation
cytoplasm [GO:0005737];
cytosol [GO:0005829];
endosome membrane [GO:0010008];
nucleoplasm [GO:0005654]
Protein-protein interaction115717
Phylogenetic treeQ15750
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-0.6989768176531020.03400668460493470.0723121826136535
AZA vs. DISU-0.2057596419403030.4177317701338850.911342924190573
AZA vs. IL7-0.1658292344962280.3922608730087370.999311006273513
AZA vs. SAHA-0.4319474803991580.07945221934072340.35080924263095
DISU vs. CD30.4816456608822840.1853771227326320.300826218976391
DISU vs. IL70.03005958485503430.9053590262597560.982189124739072
DISU vs. SAHA-0.2237942827604690.4448270811572740.789431675407925
DMSO vs. AZA0.01503376419200770.929183933964971
DMSO vs. CD30.702057725239970.02916773618412730.0613830257860342
DMSO vs. DISU0.2186796408354290.371897696086220.852378574428772
DMSO vs. IL7-0.173287181960390.3388578846989730.809025210601526
DMSO vs. SAHA-0.4519167688466750.05706749866937550.272690003946151
HIV vs. Mock in Activation0.06375794637518840.9187235981814940.999983755607037
HIV vs. Mock in Latency0.08992889297849330.5891493541960640.999834320637052
IL7 vs. CD30.5385375289873450.09533068400629690.182767667263662
SAHA vs. CD30.2437712807077940.4918608361832260.601624865787957
SAHA vs. IL7-0.2683206526072750.2733741795929590.52076865704338
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
-1.7 0.001027351 -1.4 0.011351042 -1.5 0.086948179
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) unknown
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.0446745 0.828138
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
0.98 0.999 1.115 1.122 0.986
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
2J4O X-ray 2.2Å A=1-401.
2POM X-ray 2.2Å A=1-370.
2POP X-ray 3.1Å A/C=1-370.
2YDS X-ray 2.5Å T=392-398.
2YIY X-ray 2.4Å A=468-497.
4AY5 X-ray 3.1Å I/J/K/L=389-399.
4AY6 X-ray 3.3Å E/F/G/H=389-401.
4GS6 X-ray 2.2Å A=468-504.
4KA3 X-ray 2.7Å B=395-415.
4L3P X-ray 2.6Å A=468-504.
4L53 X-ray 2.5Å A=468-496.
4O91 X-ray 2.3Å A=468-504.
5DIY X-ray 2.0Å P/Q=392-398.
5E7R X-ray 2.1Å A=468-504.
5JGA X-ray 2.0Å A=468-504.
5JGB X-ray 2.8Å A=468-504.
5JGD X-ray 3.1Å A=468-504.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04010 MAPK signaling pathway - Homo sapiens (human)
hsa04064 NF-kappa B signaling pathway - Homo sapiens (human)
hsa04380 Osteoclast differentiation - Homo sapiens (human)
hsa04620 Toll-like receptor signaling pathway - Homo sapiens (human)
hsa04621 NOD-like receptor signaling pathway - Homo sapiens (human)
hsa04668 TNF signaling pathway - Homo sapiens (human)
hsa05140 Leishmaniasis - Homo sapiens (human)
hsa05145 Toxoplasmosis - Homo sapiens (human)
hsa05168 Herpes simplex infection - Homo sapiens (human)
hsa05169 Epstein-Barr virus infection - Homo sapiens (human)