Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0007290
UniProt IDP51692
Primary gene name(s)STAT5B
Synonym gene name(s)unknown
Protein nameSignal transducer and activator of transcription 5B
Protein functionCarries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription, PubMed:11773439. Positively regulates hematopoietic/erythroid differentiation, PubMed:20702587. {ECO:0000269|PubMed:11773439, ECO:0000269|PubMed:20702587}.
Subcellular locationCytoplasm {ECO:0000250|UniProtKB:P42232}. Nucleus {ECO:0000250|UniProtKB:P42232}. Note=Translocated into the nucleus in response to phosphorylation. {ECO:0000250}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P51692
Gene Ontology
(Biological Process)
Complete annatation
2-oxoglutarate metabolic process [GO:0006103];
allantoin metabolic process [GO:0000255];
cellular response to epidermal growth factor stimulus [GO:0071364];
cellular response to growth factor stimulus [GO:0071363];
cellular response to hormone stimulus [GO:0032870];
citrate metabolic process [GO:0006101];
creatine metabolic process [GO:0006600];
creatinine metabolic process [GO:0046449];
development of secondary female sexual characteristics [GO:0046543];
development of secondary male sexual characteristics [GO:0046544];
fatty acid metabolic process [GO:0006631];
female pregnancy [GO:0007565];
isoleucine metabolic process [GO:0006549];
JAK-STAT cascade [GO:0007259];
JAK-STAT cascade involved in growth hormone signaling pathway [GO:0060397];
lactation [GO:0007595];
lipid storage [GO:0019915];
luteinization [GO:0001553];
mast cell migration [GO:0097531];
natural killer cell differentiation [GO:0001779];
negative regulation of apoptotic process [GO:0043066];
negative regulation of erythrocyte differentiation [GO:0045647];
oxaloacetate metabolic process [GO:0006107];
Peyer's patch development [GO:0048541];
positive regulation of activated T cell proliferation [GO:0042104];
positive regulation of B cell differentiation [GO:0045579];
positive regulation of erythrocyte differentiation [GO:0045648];
positive regulation of gamma-delta T cell differentiation [GO:0045588];
positive regulation of inflammatory response [GO:0050729];
positive regulation of interleukin-2 biosynthetic process [GO:0045086];
positive regulation of mitotic cell cycle [GO:0045931];
positive regulation of multicellular organism growth [GO:0040018];
positive regulation of natural killer cell differentiation [GO:0032825];
positive regulation of natural killer cell mediated cytotoxicity [GO:0045954];
positive regulation of natural killer cell proliferation [GO:0032819];
positive regulation of transcription from RNA polymerase II promoter [GO:0045944];
progesterone metabolic process [GO:0042448];
prolactin signaling pathway [GO:0038161];
regulation of epithelial cell differentiation [GO:0030856];
regulation of multicellular organism growth [GO:0040014];
regulation of steroid metabolic process [GO:0019218];
regulation of transcription from RNA polymerase II promoter [GO:0006357];
response to estradiol [GO:0032355];
response to interleukin-15 [GO:0070672];
response to interleukin-2 [GO:0070669];
response to interleukin-4 [GO:0070670];
succinate metabolic process [GO:0006105];
taurine metabolic process [GO:0019530];
T cell differentiation in thymus [GO:0033077];
T cell homeostasis [GO:0043029];
valine metabolic process [GO:0006573]
Gene Ontology
(Molecular Function)
Complete annatation
chromatin binding [GO:0003682];
glucocorticoid receptor binding [GO:0035259];
protein dimerization activity [GO:0046983];
protein tyrosine kinase activity [GO:0004713];
RNA polymerase II core promoter sequence-specific DNA binding [GO:0000979];
signal transducer activity [GO:0004871];
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding [GO:0001077];
transcription factor activity, sequence-specific DNA binding [GO:0003700]
Gene Ontology
(Cellular Component)
Complete annatation
cytoplasm [GO:0005737];
cytosol [GO:0005829];
nucleoplasm [GO:0005654];
nucleus [GO:0005634]
Protein-protein interaction112654
Phylogenetic treeP51692
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-0.06683264405179130.8388972631532280.891698737225021
AZA vs. DISU-0.0433344190760760.8637400713760180.991133096247651
AZA vs. IL7-0.1619032368932080.398631337161430.999311006273513
AZA vs. SAHA-0.05433555871921240.8233456505932340.956625255596125
DISU vs. CD30.01094570002828340.9761031354359630.984989869029435
DISU vs. IL7-0.1275054576027020.612059843710880.881022793872281
DISU vs. SAHA-0.009608296431372890.9736562939692490.995655720342689
DMSO vs. AZA0.02673041298003120.8727765972710721
DMSO vs. CD30.07901219057117890.8057167705546540.862634009551976
DMSO vs. DISU0.06736787870647020.7820655578196640.972448065006312
DMSO vs. IL7-0.1809620011350060.3130327032048490.794974393667974
DMSO vs. SAHA-0.08684214949020150.7119906286708760.913419844496906
HIV vs. Mock in Activation0.1884624060654290.7619384346991970.999983755607037
HIV vs. Mock in Latency-0.006995087564045210.9660758068094040.999834320637052
IL7 vs. CD3-0.08740661727898260.7870672624760270.859546793747367
SAHA vs. CD3-0.01194309661632370.973124332206260.981569813750586
SAHA vs. IL70.1040100773970620.6687717185734160.841140165688417
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) unknown
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -0.636811 0.000305467
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
1.002 0.787 0.86 0.961 0.974
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

Drugbank ID Drug Name Drug Status Pharmacological Action Drug Action
DB01254 Dasatinib approved, investigational unknown inhibitor

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
integrase interacts with 24968937
Envelope surface glycoprotein gp120 downregulates 11485409
capsid downregulated by 17332243
capsid upregulates 16289657

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04012 ErbB signaling pathway - Homo sapiens (human)
hsa04062 Chemokine signaling pathway - Homo sapiens (human)
hsa04630 Jak-STAT signaling pathway - Homo sapiens (human)
hsa04658 Th1 and Th2 cell differentiation - Homo sapiens (human)
hsa04659 Th17 cell differentiation - Homo sapiens (human)
hsa04917 Prolactin signaling pathway - Homo sapiens (human)
hsa04933 AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)
hsa05161 Hepatitis B - Homo sapiens (human)
hsa05162 Measles - Homo sapiens (human)
hsa05166 HTLV-I infection - Homo sapiens (human)
hsa05200 Pathways in cancer - Homo sapiens (human)
hsa05203 Viral carcinogenesis - Homo sapiens (human)
hsa05220 Chronic myeloid leukemia - Homo sapiens (human)
hsa05221 Acute myeloid leukemia - Homo sapiens (human)