Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0007289
UniProt IDP42229
Primary gene name(s)STAT5A
Synonym gene name(s)STAT5
Protein nameSignal transducer and activator of transcription 5A
Protein functionCarries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Mediates cellular responses to ERBB4. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation. {ECO:0000269|PubMed:11773439, ECO:0000269|PubMed:15534001}.
Subcellular locationCytoplasm {ECO:0000269|PubMed:15534001}. Nucleus {ECO:0000269|PubMed:15534001}. Note=Translocated into the nucleus in response to phosphorylation.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P42229
Gene Ontology
(Biological Process)
Complete annatation
2-oxoglutarate metabolic process [GO:0006103];
allantoin metabolic process [GO:0000255];
citrate metabolic process [GO:0006101];
creatine metabolic process [GO:0006600];
creatinine metabolic process [GO:0046449];
fatty acid metabolic process [GO:0006631];
isoleucine metabolic process [GO:0006549];
JAK-STAT cascade [GO:0007259];
JAK-STAT cascade involved in growth hormone signaling pathway [GO:0060397];
lactation [GO:0007595];
oxaloacetate metabolic process [GO:0006107];
positive regulation of blood vessel endothelial cell migration [GO:0043536];
positive regulation of endothelial cell proliferation [GO:0001938];
prolactin signaling pathway [GO:0038161];
regulation of multicellular organism growth [GO:0040014];
regulation of transcription from RNA polymerase II promoter [GO:0006357];
succinate metabolic process [GO:0006105];
taurine metabolic process [GO:0019530];
transcription, DNA-templated [GO:0006351];
valine metabolic process [GO:0006573]
Gene Ontology
(Molecular Function)
Complete annatation
DNA binding [GO:0003677];
protein tyrosine kinase activity [GO:0004713];
signal transducer activity [GO:0004871];
transcription factor activity, sequence-specific DNA binding [GO:0003700]
Gene Ontology
(Cellular Component)
Complete annatation
cytoplasm [GO:0005737];
cytosol [GO:0005829];
nucleoplasm [GO:0005654]
Protein-protein interaction112653
Phylogenetic treeP42229
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD32.856046379799864.44089209850063e-161.7430501486615e-14
AZA vs. DISU0.08346468981954920.7428285889429810.976008954784031
AZA vs. IL7-0.02961677574819060.8777891914087750.999311006273513
AZA vs. SAHA-0.1896070199177810.4382619755450410.786543095654665
DISU vs. CD3-2.784366508650481.33171251803788e-124.63608186995449e-11
DISU vs. IL7-0.1226101886143810.6276103763815830.887792724020691
DISU vs. SAHA-0.2708667008847230.3533489937223260.73062511303574
DMSO vs. AZA0.06532239150038640.6973649021617271
DMSO vs. CD3-2.802812658034913.33066907387547e-161.17234882238163e-14
DMSO vs. DISU-0.02017185246039980.934297572946740.991196107391884
DMSO vs. IL7-0.08742372182878070.627336074710450.91917755312917
DMSO vs. SAHA-0.2601486734539590.270561907367860.620255850776019
HIV vs. Mock in Activation0.2880218063913760.6431195751371480.999983755607037
HIV vs. Mock in Latency0.03419595022869260.8361901925016890.999834320637052
IL7 vs. CD3-2.87996151379441.11022302462516e-165.41566072821197e-15
SAHA vs. CD3-3.068793748118751.4432899320127e-156.99369108534773e-14
SAHA vs. IL7-0.1623536824725090.505481404278830.732445130068161
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
-0.3394 0.03644

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) unknown
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -0.395737 0.0017721
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
1.02 0.746 0.738 0.87 0.945
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Envelope surface glycoprotein gp120 downregulates 11485409
capsid downregulated by 17332243
capsid upregulates 16289657

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04012 ErbB signaling pathway - Homo sapiens (human)
hsa04630 Jak-STAT signaling pathway - Homo sapiens (human)
hsa04658 Th1 and Th2 cell differentiation - Homo sapiens (human)
hsa04659 Th17 cell differentiation - Homo sapiens (human)
hsa04917 Prolactin signaling pathway - Homo sapiens (human)
hsa04933 AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)
hsa05161 Hepatitis B - Homo sapiens (human)
hsa05162 Measles - Homo sapiens (human)
hsa05166 HTLV-I infection - Homo sapiens (human)
hsa05200 Pathways in cancer - Homo sapiens (human)
hsa05203 Viral carcinogenesis - Homo sapiens (human)
hsa05220 Chronic myeloid leukemia - Homo sapiens (human)
hsa05221 Acute myeloid leukemia - Homo sapiens (human)