Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0007282
UniProt IDQ92783
Primary gene name(s)STAM
Synonym gene name(s)STAM1
Protein nameSignal transducing adapter molecule 1
Protein functionInvolved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body, MVBs when complexed with HGS, ESCRT-0 complex. The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.
Subcellular locationCytoplasm {ECO:0000305}. Early endosome membrane {ECO:0000305};
Peripheral membrane protein {ECO:0000305};
Cytoplasmic side {ECO:0000305}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q92783
Gene Ontology
(Biological Process)
Complete annatation
autophagy [GO:0006914];
endosomal transport [GO:0016197];
intracellular protein transport [GO:0006886];
multivesicular body assembly [GO:0036258];
negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059];
positive regulation of exosomal secretion [GO:1903543];
regulation of extracellular exosome assembly [GO:1903551];
signal transduction [GO:0007165]
Gene Ontology
(Molecular Function)
Complete annatation
SH3/SH2 adaptor activity [GO:0005070]
Gene Ontology
(Cellular Component)
Complete annatation
cytosol [GO:0005829];
early endosome membrane [GO:0031901];
ESCRT-0 complex [GO:0033565]
Protein-protein interaction113722
Phylogenetic treeQ92783
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD31.261104291649320.0001499632675785460.000689730353660006
AZA vs. DISU0.2839887553584820.2639890015710080.841884029411858
AZA vs. IL70.1952183247850270.3148736351312010.999311006273513
AZA vs. SAHA0.1458763054158010.5526112453085790.847322557662354
DISU vs. CD3-0.990195029709530.006787317548974550.0210092427197412
DISU vs. IL7-0.09773282348527650.6991421822411950.92282523110357
DISU vs. SAHA-0.1368205074396790.6398353862388950.888705771880011
DMSO vs. AZA-0.03505118388514090.8367084312570951
DMSO vs. CD3-1.306567339711575.85942306232656e-050.000279785129743105
DMSO vs. DISU-0.3206679983832720.1910910959104470.707325086600012
DMSO vs. IL70.2373935878111060.1915242323865160.701710769886993
DMSO vs. SAHA0.17374936061290.4643457517732360.792317765830935
HIV vs. Mock in Activation0.2948526213597310.6358265776203610.999983755607037
HIV vs. Mock in Latency0.09172047368651430.5828465880753510.999834320637052
IL7 vs. CD3-1.058144602988240.001125623876154890.00469856789955211
SAHA vs. CD3-1.14022207983980.001456321122361490.00495076907601798
SAHA vs. IL7-0.05293882523431980.8291215566869760.926134001148535
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) unknown
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.330756 0.0171733
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
0.956 0.893 0.922 0.89 0.976
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
203544_s_at 1.41 No downregulated in CD8+ cells

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
2L0A NMR - A=207-267.
3F1I X-ray 2.3Å C/S=301-377.
3LDZ X-ray 2.6Å A/B/C/D=4-143.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04144 Endocytosis - Homo sapiens (human)
hsa04630 Jak-STAT signaling pathway - Homo sapiens (human)