Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0007209
UniProt IDQ9UNH7
Primary gene name(s)SNX6
Synonym gene name(s)unknown
Protein nameSorting nexin-6
Protein functionInvolved in several stages of intracellular trafficking. Interacts with membranes phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 4,5-bisphosphate, Probable. Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex, PubMed:19935774. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network, TGN and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier, ETC, Probable. Does not have in vitro vesicle-to-membrane remodeling activity, PubMed:23085988. Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptor IGF2R, PubMed:17148574. May function as link between transport vesicles and dynactin, Probable. Negatively regulates retrograde transport of BACE1 from the cell surface to the trans-Golgi network, PubMed:20354142. Involved in E-cadherin sorting and degradation; inhibits PIP5K1C isoform 3-mediated E-cadherin degradation, PubMed:24610942. In association with GIT1 involved in EGFR degradation. Promotes lysosomal degradation of CDKN1B, By similarity. May contribute to transcription regulation, Probable. {ECO:0000250|UniProtKB:Q6P8X1, ECO:0000269|PubMed:17148574, ECO:0000269|PubMed:19935774, ECO:0000269|PubMed:20354142, ECO:0000269|PubMed:23085988, ECO:0000269|PubMed:24610942, ECO:0000303|PubMed:19935774, ECO:0000303|PubMed:20830743, ECO:0000305}.
Subcellular locationEarly endosome {ECO:0000269|PubMed:11485546, ECO:0000269|PubMed:17148574, ECO:0000269|PubMed:19935774}. Early endosome membrane {ECO:0000269|PubMed:19935774, ECO:0000303|PubMed:11485546};
Peripheral membrane protein {ECO:0000269|PubMed:11485546};
Cytoplasmic side {ECO:0000305}. Cytoplasmic vesicle {ECO:0000269|PubMed:20354142}. Cytoplasm {ECO:0000269|PubMed:20830743}. Nucleus {ECO:0000269|PubMed:11591366, ECO:0000269|PubMed:20830743}. Note=Interaction with SNX1 or SNX2 promotes location at endosome membranes, PubMed:19935774. Only a minor proportion is seen in the nucleus. {ECO:0000269|PubMed:19935774}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q9UNH7
Gene Ontology
(Biological Process)
Complete annatation
endocytosis [GO:0006897];
intracellular protein transport [GO:0006886];
negative regulation of epidermal growth factor-activated receptor activity [GO:0007175];
negative regulation of transcription, DNA-templated [GO:0045892];
negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512];
regulation of macroautophagy [GO:0016241];
retrograde transport, endosome to Golgi [GO:0042147];
vesicle organization [GO:0016050]
Gene Ontology
(Molecular Function)
Complete annatation
dynactin binding [GO:0034452];
phosphatidylinositol binding [GO:0035091];
protein heterodimerization activity [GO:0046982];
protein homodimerization activity [GO:0042803]
Gene Ontology
(Cellular Component)
Complete annatation
cytoplasm [GO:0005737];
cytoplasmic, membrane-bounded vesicle [GO:0016023];
cytosol [GO:0005829];
early endosome membrane [GO:0031901];
extrinsic component of membrane [GO:0019898];
intracellular [GO:0005622];
nucleus [GO:0005634];
retromer, tubulation complex [GO:0030905];
retromer complex [GO:0030904];
tubular endosome [GO:0097422]
Protein-protein interaction121852
Phylogenetic treeQ9UNH7
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD30.3750934206463680.2531243463233360.365885695577378
AZA vs. DISU0.1210689797260440.6319517945569550.960057478314726
AZA vs. IL70.1269779116865020.5090046176443810.999311006273513
AZA vs. SAHA-0.2284137902179210.349150766865880.720084643554013
DISU vs. CD3-0.2667581966258480.4620431130827810.591256022520657
DISU vs. IL7-0.003114047058412410.9901279779752270.999074917535244
DISU vs. SAHA-0.3484597841212840.2318723409557690.609334351976746
DMSO vs. AZA-0.0296620836878780.8594668398452621
DMSO vs. CD3-0.4165299865944720.1940131905459330.292018055307671
DMSO vs. DISU-0.1526904957001760.531193879758090.918454079411213
DMSO vs. IL70.1638603580442080.3623326461169890.824863342048381
DMSO vs. SAHA-0.2053598973402080.3836939456383390.73068630966836
HIV vs. Mock in Activation-0.227335524580820.7148588057019230.999983755607037
HIV vs. Mock in Latency0.03605089027168410.8270193274841740.999834320637052
IL7 vs. CD3-0.2398086408402510.4552176574282830.589020151980127
SAHA vs. CD3-0.6282719110831060.07669565175231860.140711403933217
SAHA vs. IL7-0.3590484023319330.1407826303480780.353751853620092
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) unknown
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -0.142067 0.341297
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
1.014 1.03 1.169 1.19 1.023
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Nef requires 25496667

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04144 Endocytosis - Homo sapiens (human)