Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0007115
UniProt IDP11166
Primary gene name(s)SLC2A1
Synonym gene name(s)GLUT1
Protein nameSolute carrier family 2, facilitated glucose transporter member 1
Protein functionFacilitative glucose transporter. This isoform may be responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses. {ECO:0000269|PubMed:18245775, ECO:0000269|PubMed:19449892}.
Subcellular locationCell membrane;
Multi-pass membrane protein. Melanosome. Note=Localizes primarily at the cell surface. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P11166
Gene Ontology
(Biological Process)
Complete annatation
cellular response to glucose starvation [GO:0042149];
glucose transmembrane transport [GO:1904659];
glucose transport [GO:0015758];
lactose biosynthetic process [GO:0005989];
L-ascorbic acid metabolic process [GO:0019852];
protein complex assembly [GO:0006461];
regulation of insulin secretion [GO:0050796];
response to osmotic stress [GO:0006970]
Gene Ontology
(Molecular Function)
Complete annatation
dehydroascorbic acid transporter activity [GO:0033300];
D-glucose transmembrane transporter activity [GO:0055056];
glucose transmembrane transporter activity [GO:0005355];
identical protein binding [GO:0042802];
protein self-association [GO:0043621];
xenobiotic transporter activity [GO:0042910]
Gene Ontology
(Cellular Component)
Complete annatation
apical plasma membrane [GO:0016324];
basolateral plasma membrane [GO:0016323];
blood microparticle [GO:0072562];
caveola [GO:0005901];
cell-cell junction [GO:0005911];
cortical actin cytoskeleton [GO:0030864];
cytosol [GO:0005829];
extracellular exosome [GO:0070062];
female pronucleus [GO:0001939];
Golgi membrane [GO:0000139];
integral component of plasma membrane [GO:0005887];
melanosome [GO:0042470];
membrane [GO:0016020];
midbody [GO:0030496];
plasma membrane [GO:0005886]
Protein-protein interaction112404
Phylogenetic treeP11166
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-0.5640136168699740.09247514698243940.165140452052053
AZA vs. DISU-0.3885370015445470.1269387471432930.690785081024551
AZA vs. IL70.06589180246045090.7320916350641050.999311006273513
AZA vs. SAHA-0.4470704262943370.06797638389561710.321042639246108
DISU vs. CD30.1636942199674420.6816470943736820.775775636133551
DISU vs. IL70.4449406313193940.07971671319238870.375202315935359
DISU vs. SAHA-0.05626476990353350.8485510945634010.959738352432646
DMSO vs. AZA0.07369841581530940.6606541025658251
DMSO vs. CD30.6245381364123670.05554459768669130.105175887902213
DMSO vs. DISU0.4598811390616940.06174409394346210.47595063720101
DMSO vs. IL7-0.0001231580120297220.999453999493710.999784441946487
DMSO vs. SAHA-0.5255768322278780.02635308046565710.169295513937732
HIV vs. Mock in Activation0.2311341532782350.7543800443671390.999983755607037
HIV vs. Mock in Latency0.0002255025583662810.998911636432580.999834320637052
IL7 vs. CD30.6360994390680990.05422864071674490.117525276998346
SAHA vs. CD30.0939493896259660.7927252682874210.852703054467626
SAHA vs. IL7-0.5154851015679980.03494387180728340.144286521321913
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) unknown
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.3455 0.0077978
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
1.124 0.751 1.103 0.844 0.779
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

Drugbank ID Drug Name Drug Status Pharmacological Action Drug Action
DB00292 Etomidate approved unknown inhibitor
DB08830 Dehydroascorbic Acid experimental unknown unknown
DB08831 2-deoxyglucose experimental, investigational unknown unknown

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
1SUK Model - A=1-492.
4PYP X-ray 3.1Å A=1-492.
5EQG X-ray 2.9Å A=1-492.
5EQH X-ray 2.9Å A=1-492.
5EQI X-ray 3.0Å A=1-492.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
HIV-1 virus replication enhanced by expression of human gene 22308487

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04066 HIF-1 signaling pathway - Homo sapiens (human)
hsa04911 Insulin secretion - Homo sapiens (human)
hsa04919 Thyroid hormone signaling pathway - Homo sapiens (human)
hsa04920 Adipocytokine signaling pathway - Homo sapiens (human)
hsa04922 Glucagon signaling pathway - Homo sapiens (human)
hsa04931 Insulin resistance - Homo sapiens (human)
hsa04976 Bile secretion - Homo sapiens (human)
hsa05166 HTLV-I infection - Homo sapiens (human)
hsa05200 Pathways in cancer - Homo sapiens (human)
hsa05211 Renal cell carcinoma - Homo sapiens (human)
hsa05230 Central carbon metabolism in cancer - Homo sapiens (human)