Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0007112
UniProt IDP12236
Primary gene name(s)SLC25A6
Synonym gene name(s)ANT3
Protein nameADP/ATP translocase 3
Protein functionCatalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. May participate in the formation of the permeability transition pore complex, PTPC responsible for the release of mitochondrial products that triggers apoptosis. {ECO:0000269|PubMed:15033708}.
Subcellular locationMitochondrion inner membrane;
Multi-pass membrane protein. Note=The complex formed with ARL2BP, ARL2 and SLC25A6 is expressed in mitochondria. {ECO:0000250}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P12236
Gene Ontology
(Biological Process)
Complete annatation
active induction of host immune response by virus [GO:0046732];
apoptotic process [GO:0006915];
protein targeting to mitochondrion [GO:0006626];
regulation of insulin secretion [GO:0050796]
Gene Ontology
(Molecular Function)
Complete annatation
adenine transmembrane transporter activity [GO:0015207];
ATP:ADP antiporter activity [GO:0005471];
structural constituent of ribosome [GO:0003735]
Gene Ontology
(Cellular Component)
Complete annatation
integral component of membrane [GO:0016021];
mitochondrial inner membrane [GO:0005743];
mitochondrial inner membrane presequence translocase complex [GO:0005744];
mitochondrion [GO:0005739];
nucleus [GO:0005634]
Protein-protein interaction106790
Phylogenetic treeP12236
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-0.1756234678267260.5910114529907050.697114150843317
AZA vs. DISU-0.3690987080354150.1443214754463030.718797155225174
AZA vs. IL70.04004340352792570.8350591463465710.999311006273513
AZA vs. SAHA-0.220669073235530.365331937324450.732607905178762
DISU vs. CD3-0.2057496810819590.5697443886578610.686352346729689
DISU vs. IL70.4001587326250360.1149350514948750.444154294100291
DISU vs. SAHA0.1497169846922030.6084023515033970.87683757986905
DMSO vs. AZA0.05490393880877690.7421387393102581
DMSO vs. CD30.2145141365128180.5021262239546910.610288952309594
DMSO vs. DISU0.4208274234073390.08529547440020490.5399984064138
DMSO vs. IL7-0.006907510905194630.9692725587143010.993893941764584
DMSO vs. SAHA-0.2810239311705880.2323259984991040.579220036952853
HIV vs. Mock in Activation0.1725533849557290.7835232507700690.999983755607037
HIV vs. Mock in Latency-0.2704782544558240.09987865582912160.999834320637052
IL7 vs. CD30.2234574624522960.488386779470580.619494565931166
SAHA vs. CD3-0.06996741506780490.8430184226536610.889199083717028
SAHA vs. IL7-0.2646774063188960.2764169490198810.523982531378985
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) unknown
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -0.62724 0.000580925
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
1.001 1.025 1.01 1.046 0.952
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
0.83 0.0034 -0.2 0.2058 -0.3 0.0209 Cell growth and proliferation at 4 hpi
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

Drugbank ID Drug Name Drug Status Pharmacological Action Drug Action
DB00720 Clodronate approved, investigational, vet_approved yes inhibitor

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04020 Calcium signaling pathway - Homo sapiens (human)
hsa04022 cGMP-PKG signaling pathway - Homo sapiens (human)
hsa05012 Parkinson's disease - Homo sapiens (human)
hsa05016 Huntington's disease - Homo sapiens (human)
hsa05164 Influenza A - Homo sapiens (human)
hsa05166 HTLV-I infection - Homo sapiens (human)