Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0007109
UniProt IDP12235
Primary gene name(s)SLC25A4
Synonym gene name(s)ANT1
Protein nameADP/ATP translocase 1
Protein functionCatalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane.
Subcellular locationMitochondrion inner membrane;
Multi-pass membrane protein.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P12235
Gene Ontology
(Biological Process)
Complete annatation
apoptotic mitochondrial changes [GO:0008637];
generation of precursor metabolites and energy [GO:0006091];
mitochondrial genome maintenance [GO:0000002];
negative regulation of necroptotic process [GO:0060546];
regulation of insulin secretion [GO:0050796];
transport [GO:0006810];
viral process [GO:0016032]
Gene Ontology
(Molecular Function)
Complete annatation
adenine transmembrane transporter activity [GO:0015207];
structural constituent of ribosome [GO:0003735]
Gene Ontology
(Cellular Component)
Complete annatation
integral component of plasma membrane [GO:0005887];
mitochondrial inner membrane [GO:0005743];
mitochondrion [GO:0005739];
myelin sheath [GO:0043209];
nucleus [GO:0005634]
Protein-protein interaction106788
Phylogenetic treeP12235
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD30.6085316135602720.08196217896936410.149574277930289
AZA vs. DISU-0.01234236479072670.9656667343102810.996865938615426
AZA vs. IL70.220501184337220.3472241860701140.999311006273513
AZA vs. SAHA-0.2145826045963390.4512198204784310.792645096596185
DISU vs. CD3-0.6341648206074680.09563219047719720.179947527056955
DISU vs. IL70.226554110152570.4207572376547880.778255819412057
DISU vs. SAHA-0.1992711288920190.5365278208291680.844315629917133
DMSO vs. AZA-0.04328298013189250.8529207474116921
DMSO vs. CD3-0.6678561625038330.05000064116630330.09637406079457
DMSO vs. DISU-0.03441524683340640.9009061833251080.988283279918411
DMSO vs. IL70.2724465874131620.2178011169908330.726228277560621
DMSO vs. SAHA-0.175416536620240.522540376730660.825926168611198
HIV vs. Mock in Activation-0.1426665634781350.825790716508010.999983755607037
HIV vs. Mock in Latency-0.0997174969123120.6320721901402430.999834320637052
IL7 vs. CD3-0.3758361723527280.270257458943740.405141611990255
SAHA vs. CD3-0.8460427006215810.02482220720226250.0551889440156529
SAHA vs. IL7-0.4385777453460570.1159042000116520.313872835029703
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) unknown
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.790143 0.000305467
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
1.026 1.106 1.186 1.221 1.08
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

Drugbank ID Drug Name Drug Status Pharmacological Action Drug Action
DB00171 Adenosine triphosphate approved, nutraceutical unknown unknown
DB00720 Clodronate approved, investigational, vet_approved yes inhibitor
DB02426 Carboxyatractyloside experimental unknown unknown
DB03429 Cardiolipin experimental unknown unknown
DB04178 Di-Stearoyl-3-Sn-Phosphatidylcholine experimental unknown unknown
DB01736 [3-(Dodecanoylamino)Propyl](Hydroxy)Dimethylammonium experimental unknown unknown

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04020 Calcium signaling pathway - Homo sapiens (human)
hsa04022 cGMP-PKG signaling pathway - Homo sapiens (human)
hsa05012 Parkinson's disease - Homo sapiens (human)
hsa05016 Huntington's disease - Homo sapiens (human)
hsa05166 HTLV-I infection - Homo sapiens (human)