Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0007022
UniProt IDQ99442
Primary gene name(s)SEC62
Synonym gene name(s)TLOC1
Protein nameTranslocation protein SEC62
Protein functionRequired for preprotein translocation. {ECO:0000250}.
Subcellular locationEndoplasmic reticulum membrane {ECO:0000250};
Multi-pass membrane protein {ECO:0000250}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q99442
Gene Ontology
(Biological Process)
Complete annatation
cotranslational protein targeting to membrane [GO:0006613];
IRE1-mediated unfolded protein response [GO:0036498];
posttranslational protein targeting to membrane [GO:0006620]
Gene Ontology
(Molecular Function)
Complete annatation
protein transporter activity [GO:0008565];
receptor activity [GO:0004872]
Gene Ontology
(Cellular Component)
Complete annatation
aggresome [GO:0016235];
cytosol [GO:0005829];
endoplasmic reticulum [GO:0005783];
endoplasmic reticulum membrane [GO:0005789];
integral component of membrane [GO:0016021];
intermediate filament cytoskeleton [GO:0045111];
membrane [GO:0016020];
rough endoplasmic reticulum [GO:0005791]
Protein-protein interaction112950
Phylogenetic treeQ99442
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
      unknown
Brass et al., Science, 2008
      unknown
Smith et al., J. Immunol, 2010
      unknown
Interferon-stimulated
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model


DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD30.3033369840933440.3547263121932220.475915660452164
AZA vs. DISU0.07517746686963860.7668483025333970.976021571236163
AZA vs. IL70.02620048722621570.8914613843872230.999311006273513
AZA vs. SAHA-0.2630431751410740.2808404562590930.653248543534301
DISU vs. CD3-0.2404957675090530.511072630576570.635269137734907
DISU vs. IL7-0.05768515972325380.8194212461932020.961243368243154
DISU vs. SAHA-0.3381642836631640.2485254571646990.627062204946918
DMSO vs. AZA-0.1932265241285670.2484214336327181
DMSO vs. CD3-0.5065883800788270.1139207201323130.189679006276889
DMSO vs. DISU-0.2699000621521160.270606355459660.790011192711562
DMSO vs. IL70.2264667577379740.2075826092622430.716699329473652
DMSO vs. SAHA-0.07814722163712780.7400738648769410.92450038820069
HIV vs. Mock in Activation-0.1832432346804210.7683278390803860.999983755607037
HIV vs. Mock in Latency0.03024446922887970.8544216295177170.999834320637052
IL7 vs. CD3-0.2678826094559490.4046268572997940.541839074278589
SAHA vs. CD3-0.5924635077227250.09434857334735350.166063186211705
SAHA vs. IL7-0.2937792027613780.227603363407050.468040855733291
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander -0.894 1.36E-09 7.13E-08
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) unknown
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -0.0775629 0.776324
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
1.042 0.969 1.028 1.172 0.974
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
208943_s_at 1.44 No downregulated in CD8+ cells

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Envelope transmembrane glycoprotein gp41 interacts with 22190034

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa03060 Protein export - Homo sapiens (human)
hsa04141 Protein processing in endoplasmic reticulum - Homo sapiens (human)
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