Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0006620
UniProt IDQ9UL26
Primary gene name(s)RAB22A
Synonym gene name(s)RAB22
Protein nameRas-related protein Rab-22A
Protein functionPlays a role in endocytosis and intracellular protein transport. Mediates trafficking of TF from early endosomes to recycling endosomes. Required for NGF-mediated endocytosis of NTRK1, and subsequent neurite outgrowth. Binds GTP and GDP and has low GTPase activity. Alternates between a GTP-bound active form and a GDP-bound inactive form. {ECO:0000269|PubMed:16537905, ECO:0000269|PubMed:21849477}.
Subcellular locationEndosome membrane {ECO:0000250|UniProtKB:P51154};
Lipid-anchor {ECO:0000305}. Cell membrane {ECO:0000250|UniProtKB:P51154};
Lipid-anchor {ECO:0000305}. Early endosome {ECO:0000269|PubMed:16537905}. Late endosome {ECO:0000250|UniProtKB:P51154}. Cell projection, ruffle {ECO:0000269|PubMed:21419809}. Cytoplasmic vesicle {ECO:0000269|PubMed:21419809}. Cytoplasmic vesicle, phagosome {ECO:0000269|PubMed:21255211}. Cytoplasmic vesicle, phagosome membrane {ECO:0000305};
Lipid-anchor {ECO:0000305};
Cytoplasmic side {ECO:0000305}. Note=Recruited to phagosomes containing S.aureus or M.tuberculosis. {ECO:0000269|PubMed:21255211}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q9UL26
Gene Ontology
(Biological Process)
Complete annatation
endocytosis [GO:0006897];
endosome organization [GO:0007032];
protein transport [GO:0015031];
regulation of vesicle size [GO:0097494];
small GTPase mediated signal transduction [GO:0007264]
Gene Ontology
(Molecular Function)
Complete annatation
GDP binding [GO:0019003];
GTPase activity [GO:0003924];
GTP binding [GO:0005525]
Gene Ontology
(Cellular Component)
Complete annatation
actin cytoskeleton [GO:0015629];
early endosome [GO:0005769];
endosome membrane [GO:0010008];
extracellular exosome [GO:0070062];
late endosome [GO:0005770];
phagocytic vesicle [GO:0045335];
phagocytic vesicle membrane [GO:0030670];
plasma membrane [GO:0005886];
ruffle [GO:0001726]
Protein-protein interaction121505
Phylogenetic treeQ9UL26
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD30.4973393806455170.13007334243590.217073930620142
AZA vs. DISU0.02038640510387650.9358408409707490.995042856396371
AZA vs. IL70.09239244457631020.631718530510950.999311006273513
AZA vs. SAHA-0.192006694137750.432151050741250.781365591804438
DISU vs. CD3-0.4893703060268880.1791979939875110.293258389039309
DISU vs. IL70.06339217748285730.80145198174260.956148197591777
DISU vs. SAHA-0.2118698506261750.4675949094099080.802731342023029
DMSO vs. AZA-0.1815753006207630.2808322647441481
DMSO vs. CD3-0.6882343276883240.03228623182352020.066665581472222
DMSO vs. DISU-0.2032283790578760.4058131748017380.868858747268752
DMSO vs. IL70.2809339730807420.119661624061830.610726150261665
DMSO vs. SAHA-0.01874278210743610.9367507745264520.9846317807625
HIV vs. Mock in Activation0.02288139396225140.9706452069131120.999983755607037
HIV vs. Mock in Latency0.04429124807156090.789477331769320.999834320637052
IL7 vs. CD3-0.3961170084209120.2191115282145780.345720513428067
SAHA vs. CD3-0.715386237966190.04419577510035610.0896527568666532
SAHA vs. IL7-0.2887386046300680.2366989495221720.477963826536802
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) unknown
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -0.364974 0.00420274
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
0.985 0.998 1.002 1.089 1.019
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04144 Endocytosis - Homo sapiens (human)