Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0006613
UniProt IDQ6WKZ4
Primary gene name(s)RAB11FIP1
Synonym gene name(s)RCP
Protein nameRab11 family-interacting protein 1
Protein functionA Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis. {ECO:0000269|PubMed:11786538, ECO:0000269|PubMed:15181150, ECO:0000269|PubMed:15355514, ECO:0000269|PubMed:16920206}.
Subcellular locationRecycling endosome {ECO:0000269|PubMed:11786538, ECO:0000269|PubMed:15181150, ECO:0000269|PubMed:15280022, ECO:0000269|PubMed:15355514, ECO:0000269|PubMed:16920206}. Note=Rab11A rather than Rab4A mediates localization in the endocytic recycling compartment, ERC.;
SUBCELLULAR LOCATION: Isoform 2: Cytoplasmic vesicle, phagosome membrane. Note=Membrane-bound, isoform 2. Colocalizes with Rab11A at phagosomes, isoform 2.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q6WKZ4
Gene Ontology
(Biological Process)
Complete annatation
negative regulation of adiponectin secretion [GO:0070164];
protein transport [GO:0015031];
regulated exocytosis [GO:0045055]
Gene Ontology
(Molecular Function)
Complete annatation
Rab GTPase binding [GO:0017137]
Gene Ontology
(Cellular Component)
Complete annatation
cytoplasm [GO:0005737];
intracellular membrane-bounded organelle [GO:0043231];
phagocytic vesicle membrane [GO:0030670];
recycling endosome [GO:0055037]
Protein-protein interaction123189
Phylogenetic treeQ6WKZ4
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD31.618253283020722.03807888399243e-061.47682331440067e-05
AZA vs. DISU0.1648091239821770.5157901253069560.938437432475966
AZA vs. IL70.6586792496926990.0006481364343223770.0574668263208305
AZA vs. SAHA0.09029052396086690.7117343357348390.918972149307812
DISU vs. CD3-1.465197662412558.10880111979939e-050.000471210748187571
DISU vs. IL70.4844018370390680.05510305472971730.309407267104701
DISU vs. SAHA-0.07245368314226410.8049461603271260.949424088206534
DMSO vs. AZA-0.01561199721746450.9259104813873471
DMSO vs. CD3-1.642238885318717.87010359437623e-075.78074649679561e-06
DMSO vs. DISU-0.1814489219572240.4580716643075540.891648150492747
DMSO vs. IL70.6811749445776620.0001627928776128940.0161454120395683
DMSO vs. SAHA0.09933068455620130.6740982524556530.897786781843686
HIV vs. Mock in Activation0.1488030404524160.8110043377040530.999983755607037
HIV vs. Mock in Latency0.1373131172326490.4076092800488710.999834320637052
IL7 vs. CD3-0.9531102294219780.003642360557359110.0128454142913135
SAHA vs. CD3-1.551647404322592.84209474751274e-050.000158279260328961
SAHA vs. IL7-0.570035448436280.01993067848179630.100211823693995
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander 0.79 7.45E-10 4.45E-08
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) unknown
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.278947 0.0329414
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
0.971 0.891 0.721 0.7 0.841
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
4D0G X-ray 2.5Å C=1216-1283.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Envelope transmembrane glycoprotein gp41 required for 26034275
Envelope surface glycoprotein gp160; precursor relocalizes 23592992
Envelope surface glycoprotein gp160; precursor regulated by 23592992
Envelope surface glycoprotein gp120 regulated by 23592992
HIV-1 virus replication enhanced by expression of human gene 23592992
Envelope transmembrane glycoprotein gp41 regulated by 23592992

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04144 Endocytosis - Homo sapiens (human)