Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0006254
UniProt IDP13667
Primary gene name(s)PDIA4
Synonym gene name(s)ERP70, ERP72
Protein nameProtein disulfide-isomerase A4
Protein functionunknown
Subcellular locationEndoplasmic reticulum lumen {ECO:0000269|PubMed:12643545}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV, PubMed:17081065. {ECO:0000269|PubMed:17081065}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P13667
Gene Ontology
(Biological Process)
Complete annatation
cell redox homeostasis [GO:0045454];
chaperone-mediated protein folding [GO:0061077];
protein folding [GO:0006457];
protein secretion [GO:0009306];
response to endoplasmic reticulum stress [GO:0034976]
Gene Ontology
(Molecular Function)
Complete annatation
poly(A RNA binding [GO:0044822];
protein disulfide isomerase activity [GO:0003756]
Gene Ontology
(Cellular Component)
Complete annatation
cell surface [GO:0009986];
endoplasmic reticulum lumen [GO:0005788];
melanosome [GO:0042470]
Protein-protein interaction114966
Phylogenetic treeP13667
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD30.009044286818631510.9779595465665480.985083625332554
AZA vs. DISU-0.05897509300514580.8598042412067490.990922016964444
AZA vs. IL70.05254575080928140.7842801781216140.999311006273513
AZA vs. SAHA-0.3131136007570970.1992953292592130.566825998727054
DISU vs. CD3-0.07877068216972680.8286533967643420.883639028213476
DISU vs. IL70.102412667058040.7600881621805130.943027953475777
DISU vs. SAHA-0.2532810098795230.459029356489720.798443621244659
DMSO vs. AZA-0.06029941158639640.7184399228039431
DMSO vs. CD3-0.08275640184167570.7957455226962820.855816919494933
DMSO vs. DISU-0.003717171304368230.9911635984412810.99806609310612
DMSO vs. IL70.1204321319986730.5023768075690540.886421465631531
DMSO vs. SAHA-0.2589115088339480.2719260698861150.621692627313963
HIV vs. Mock in Activation-0.05040103871413310.9353589845129110.999983755607037
HIV vs. Mock in Latency-0.2036155184664030.232613422825490.999834320637052
IL7 vs. CD30.05137459127905770.8729492535429660.918980590770577
SAHA vs. CD3-0.346591499823590.3266077317976180.44178965247196
SAHA vs. IL7-0.3689967311359280.129871576889230.336073742352032
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) unknown
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.398785 0.0017721
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
1.018 0.947 1.218 1.291 0.954
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
3IDV X-ray 1.9Å A=53-284.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Envelope surface glycoprotein gp120 cleaved by 12218051
integrase interacts with 22190034
Envelope surface glycoprotein gp120 interacts with 20458450
Pol interacts with 22190034
Envelope surface glycoprotein gp160; precursor processed by 17301129

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04141 Protein processing in endoplasmic reticulum - Homo sapiens (human)
hsa04918 Thyroid hormone synthesis - Homo sapiens (human)
hsa05110 Vibrio cholerae infection - Homo sapiens (human)