Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0005962
UniProt IDQ9Y618
Primary gene name(s)NCOR2
Synonym gene name(s)CTG26
Protein nameNuclear receptor corepressor 2
Protein functionTranscriptional corepressor. Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 5 have different affinities for different nuclear receptors. Involved in the regulation BCL6-dependent of the germinal center, GC reactions, mainly through the control of the GC B-cells proliferation and survival. {ECO:0000269|PubMed:18212045, ECO:0000269|PubMed:23911289}.
Subcellular locationNucleus.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q9Y618
Gene Ontology
(Biological Process)
Complete annatation
cellular lipid metabolic process [GO:0044255];
negative regulation of production of miRNAs involved in gene silencing by miRNA [GO:1903799];
negative regulation of transcription from RNA polymerase II promoter [GO:0000122];
regulation of cellular ketone metabolic process by negative regulation of transcription from RNA polymerase II promoter [GO:0072365];
transcription, DNA-templated [GO:0006351]
Gene Ontology
(Molecular Function)
Complete annatation
DNA binding [GO:0003677];
histone deacetylase binding [GO:0042826];
ligand-dependent nuclear receptor binding [GO:0016922];
Notch binding [GO:0005112];
protein N-terminus binding [GO:0047485];
transcription corepressor activity [GO:0003714];
transcription factor binding [GO:0008134]
Gene Ontology
(Cellular Component)
Complete annatation
histone deacetylase complex [GO:0000118];
membrane [GO:0016020];
nuclear body [GO:0016604];
nuclear chromatin [GO:0000790];
nuclear matrix [GO:0016363];
nucleoplasm [GO:0005654];
nucleus [GO:0005634];
transcriptional repressor complex [GO:0017053]
Protein-protein interaction114974
Phylogenetic treeQ9Y618
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-0.1041222639716860.7543172297987770.829737942455639
AZA vs. DISU0.08063257447984450.7770372675271950.976444104025318
AZA vs. IL7-0.0698111975066880.7346381792271210.999311006273513
AZA vs. SAHA-0.1327735756934190.586258700615090.862724238403347
DISU vs. CD30.1735419217020340.6630628389061350.761176546620294
DISU vs. IL7-0.1602006581496810.5814565921674840.868039030196556
DISU vs. SAHA-0.2108924863723320.4721895963647690.805520001905978
DMSO vs. AZA0.01082771859017540.9490810526420951
DMSO vs. CD30.106014915578430.7445345088773990.815501845007854
DMSO vs. DISU-0.07104900268967540.7926841484353790.975402148846343
DMSO vs. IL7-0.07330796919049580.691798033294960.936954851917814
DMSO vs. SAHA-0.1494280768656760.5263843837645960.828059091721907
HIV vs. Mock in Activation0.5735792279065380.3577882298152690.999983755607037
HIV vs. Mock in Latency0.04166928726982470.8008148538187980.999834320637052
IL7 vs. CD30.03906026722542870.9075658348070320.941317842809611
SAHA vs. CD3-0.05148100635483160.884705492479530.920308674788881
SAHA vs. IL7-0.06568570812724680.7875694983950120.906930022162033
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) unknown
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -0.041656 0.841272
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
0.968 0.993 0.91 0.801 0.953
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
1KKQ X-ray 3.0Å E/F/G/H=2347-2365.
1R2B X-ray 2.2Å C/D=1422-1438.
1XC5 NMR - A=412-480.
2GPV X-ray 2.8Å G/H/I=2346-2367.
2L5G NMR - B=167-207.
2LTP NMR - A=615-685.
2ODD NMR - B=1109-1121.
2RT5 NMR - B=2518-2525.
3R29 X-ray 2.9Å C/D=2346-2361.
3R2A X-ray 3.0Å E/F=2346-2361.
4A69 X-ray 2.0Å C/D=389-480.
4OAR X-ray 2.4Å B=2346-2362.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
HIV-1 virus replication enhanced by expression of human gene 18187620

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04330 Notch signaling pathway - Homo sapiens (human)
hsa05169 Epstein-Barr virus infection - Homo sapiens (human)