Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0005547
UniProt IDQ12907
Primary gene name(s)LMAN2
Synonym gene name(s)C5orf8
Protein nameVesicular integral-membrane protein VIP36
Protein functionPlays a role as an intracellular lectin in the early secretory pathway. Interacts with N-acetyl-D-galactosamine and high-mannose type glycans and may also bind to O-linked glycans. Involved in the transport and sorting of glycoproteins carrying high mannose-type glycans, By similarity. {ECO:0000250}.
Subcellular locationEndoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000269|PubMed:10444376};
Single-pass type I membrane protein {ECO:0000269|PubMed:10444376}. Golgi apparatus membrane {ECO:0000269|PubMed:10444376};
Single-pass membrane protein {ECO:0000269|PubMed:10444376}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:10444376};
Single-pass type I membrane protein {ECO:0000269|PubMed:10444376}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q12907
Gene Ontology
(Biological Process)
Complete annatation
endoplasmic reticulum organization [GO:0007029];
ER to Golgi vesicle-mediated transport [GO:0006888];
Golgi organization [GO:0007030];
positive regulation of phagocytosis [GO:0050766];
protein transport [GO:0015031];
retrograde vesicle-mediated transport, Golgi to ER [GO:0006890]
Gene Ontology
(Molecular Function)
Complete annatation
carbohydrate binding [GO:0030246];
glycoprotein binding [GO:0001948];
heat shock protein binding [GO:0031072];
mannose binding [GO:0005537];
metal ion binding [GO:0046872]
Gene Ontology
(Cellular Component)
Complete annatation
cell surface [GO:0009986];
endoplasmic reticulum-Golgi intermediate compartment [GO:0005793];
endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116];
endoplasmic reticulum membrane [GO:0005789];
extracellular exosome [GO:0070062];
extracellular space [GO:0005615];
Golgi apparatus [GO:0005794];
Golgi membrane [GO:0000139];
integral component of plasma membrane [GO:0005887]
Protein-protein interaction116159
Phylogenetic treeQ12907
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD30.03175920992970850.9226241520694970.950215411821002
AZA vs. DISU-0.1002719529843810.6915060986507620.968313969505284
AZA vs. IL7-0.02858114411595050.8817155661409340.999311006273513
AZA vs. SAHA-0.1468043141853780.5470391444364680.845837323134201
DISU vs. CD3-0.1443562843722540.6900562498528170.782251082760226
DISU vs. IL70.06198052783683070.8054349072219880.958091343804373
DISU vs. SAHA-0.04404657506139450.8797385569323810.96945856056033
DMSO vs. AZA0.03801805102566920.8203229257840661
DMSO vs. CD3-0.007534852598350390.9811779003920740.987404480254282
DMSO vs. DISU0.1357280014267220.5776374333506120.932418621838394
DMSO vs. IL7-0.05893589601869590.7428286622633260.948604438759462
DMSO vs. SAHA-0.1894272008990330.4215885765221030.760908085345012
HIV vs. Mock in Activation0.1039560784218870.8678854520698910.999983755607037
HIV vs. Mock in Latency-0.01926872763196530.9069992882637330.999834320637052
IL7 vs. CD3-0.05454349879128390.8650174752623610.914013908491382
SAHA vs. CD3-0.201560868325080.5679361269689440.669961642792484
SAHA vs. IL7-0.1205827290747010.6203425604492990.810245538186702
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) unknown
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -0.313395 0.0295667
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
1.002 1.224 1.492 1.614 1.473
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Envelope surface glycoprotein gp160; precursor interacts with 22190034
Envelope transmembrane glycoprotein gp41 interacts with 22190034
HIV-1 virus replication enhanced by expression of human gene 18854154

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04141 Protein processing in endoplasmic reticulum - Homo sapiens (human)