Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0005498
UniProt IDP13473
Primary gene name(s)LAMP2
Synonym gene name(s)unknown
Protein nameLysosome-associated membrane glycoprotein 2
Protein functionImplicated in tumor cell metastasis. May function in protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface, plasma membrane, and inter- and intracellular signal transduction. Protects cells from the toxic effects of methylating mutagens. {ECO:0000269|PubMed:8407947}.
Subcellular locationCell membrane {ECO:0000269|PubMed:17897319};
Single-pass type I membrane protein {ECO:0000255|PROSITE-ProRule:PRU00740, ECO:0000269|PubMed:17897319}. Endosome membrane {ECO:0000269|PubMed:17897319};
Single-pass type I membrane protein {ECO:0000255|PROSITE-ProRule:PRU00740, ECO:0000269|PubMed:17897319}. Lysosome membrane {ECO:0000255|PROSITE-ProRule:PRU00740, ECO:0000269|PubMed:17897319};
Single-pass type I membrane protein {ECO:0000255|PROSITE-ProRule:PRU00740, ECO:0000269|PubMed:17897319}. Note=This protein shuttles between lysosomes, endosomes, and the plasma membrane.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P13473
Gene Ontology
(Biological Process)
Complete annatation
chaperone-mediated autophagy [GO:0061684];
muscle cell cellular homeostasis [GO:0046716];
negative regulation of protein homooligomerization [GO:0032463];
platelet degranulation [GO:0002576];
protein import [GO:0017038];
protein stabilization [GO:0050821];
regulation of protein stability [GO:0031647]
Gene Ontology
(Molecular Function)
Complete annatation
enzyme binding [GO:0019899]
Gene Ontology
(Cellular Component)
Complete annatation
chaperone-mediated autophagy translocation complex [GO:0061742];
extracellular exosome [GO:0070062];
extracellular space [GO:0005615];
integral component of membrane [GO:0016021];
late endosome [GO:0005770];
late endosome membrane [GO:0031902];
lysosomal lumen [GO:0043202];
lysosomal membrane [GO:0005765];
lysosome [GO:0005764];
membrane [GO:0016020];
phagocytic vesicle membrane [GO:0030670];
plasma membrane [GO:0005886];
platelet dense granule membrane [GO:0031088]
Protein-protein interaction110114
Phylogenetic treeP13473
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-0.4082990683740850.2126299804559830.319747989362652
AZA vs. DISU0.128321651836770.611493372201790.95757639837101
AZA vs. IL7-0.08931315951087970.6417917990516180.999311006273513
AZA vs. SAHA0.1545521748204620.5267506575050420.836639762608049
DISU vs. CD30.5236085011858890.1490093770928830.254754151105604
DISU vs. IL7-0.2266759178802130.3679018934326180.743248598699641
DISU vs. SAHA0.02721398743258740.9255508488759380.982806795139101
DMSO vs. AZA-0.08784529265389730.599442782324821
DMSO vs. CD30.3093523970465560.3331833140106070.447123340955798
DMSO vs. DISU-0.2179904050268980.371130769094580.851890501597821
DMSO vs. IL70.00576413479967630.9743926776738960.995457415013146
DMSO vs. SAHA0.2351801448647910.3189507486623620.672012684620502
HIV vs. Mock in Activation0.05952504002395760.9238102329558920.999983755607037
HIV vs. Mock in Latency-0.03269039021695260.8429288056981350.999834320637052
IL7 vs. CD30.3268558373837590.3090736107627830.446960235539425
SAHA vs. CD30.5372976452748160.1292017505087640.213947471462428
SAHA vs. IL70.2396429942926950.3261654234514220.575933372566585
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) unknown
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.0378094 0.84326
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
1.054 1.004 1.148 1.36 0.945
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
2MOF NMR - A=369-410.
2MOM NMR - A/B/C=369-410.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Vpu co-localizes with 22593165
Tat associates with 25653352
Nef co-localizes with 19912576
Vpr reduces 26186441
Pr55(Gag) co-localizes with 19474101
Nef downregulates 25275127
Vpu downregulates 25275127
matrix colocalizes with 26186441
capsid upregulates 24899193

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04142 Lysosome - Homo sapiens (human)
hsa04145 Phagosome - Homo sapiens (human)
hsa05152 Tuberculosis - Homo sapiens (human)