Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0005322
UniProt IDP11717
Primary gene name(s)IGF2R
Synonym gene name(s)MPRI
Protein nameCation-independent mannose-6-phosphate receptor
Protein functionTransport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4. {ECO:0000269|PubMed:10900005}.
Subcellular locationLysosome membrane {ECO:0000269|PubMed:10900005};
Single-pass type I membrane protein {ECO:0000269|PubMed:10900005}. Note=Colocalized with DPP4 in internalized cytoplasmic vesicles adjacent to the cell surface.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P11717
Gene Ontology
(Biological Process)
Complete annatation
animal organ regeneration [GO:0031100];
liver development [GO:0001889];
positive regulation of apoptotic process [GO:0043065];
post-embryonic development [GO:0009791];
receptor-mediated endocytosis [GO:0006898];
response to retinoic acid [GO:0032526];
signal transduction [GO:0007165];
spermatogenesis [GO:0007283]
Gene Ontology
(Molecular Function)
Complete annatation
glycoprotein binding [GO:0001948];
G-protein coupled receptor activity [GO:0004930];
identical protein binding [GO:0042802];
insulin-like growth factor-activated receptor activity [GO:0005010];
mannose binding [GO:0005537];
phosphoprotein binding [GO:0051219];
receptor activity [GO:0004872];
retinoic acid binding [GO:0001972];
transporter activity [GO:0005215]
Gene Ontology
(Cellular Component)
Complete annatation
cell surface [GO:0009986];
clathrin coat [GO:0030118];
early endosome [GO:0005769];
endocytic vesicle [GO:0030139];
endosome [GO:0005768];
extracellular exosome [GO:0070062];
extracellular space [GO:0005615];
focal adhesion [GO:0005925];
integral component of plasma membrane [GO:0005887];
late endosome [GO:0005770];
lysosomal membrane [GO:0005765];
membrane [GO:0016020];
nuclear envelope lumen [GO:0005641];
perinuclear region of cytoplasm [GO:0048471];
trans-Golgi network [GO:0005802];
trans-Golgi network membrane [GO:0032588];
trans-Golgi network transport vesicle [GO:0030140];
transport vesicle [GO:0030133]
Protein-protein interaction109703
Phylogenetic treeP11717
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-0.4334338909889450.1861272305720180.288404402095348
AZA vs. DISU0.2276888917013640.3674315694266110.896211275303082
AZA vs. IL7-0.04925250136173530.7974926419119270.999311006273513
AZA vs. SAHA0.3524985590735220.1488438133552980.491064049577098
DISU vs. CD30.6476751952863120.07472614451631390.148408682798276
DISU vs. IL7-0.2860975287675880.2562868294767980.642063823407414
DISU vs. SAHA0.126906232779830.6628419904502950.897238264315264
DMSO vs. AZA0.07994275066393670.6323831081210541
DMSO vs. CD30.5014075625127350.1180219465732630.19514878993812
DMSO vs. DISU-0.1498835557482440.5386514483517350.921311049648542
DMSO vs. IL7-0.1218220145003690.4971400557851590.885687081722074
DMSO vs. SAHA0.2661220730355730.2599753615319110.608493348912477
HIV vs. Mock in Activation0.4253656375458970.4975238642063910.999983755607037
HIV vs. Mock in Latency-0.04873504871250110.7669392758814440.999834320637052
IL7 vs. CD30.3910116805701340.2251601569398210.353267309831782
SAHA vs. CD30.7614973040655970.03181184872959350.0680972386867861
SAHA vs. IL70.3984099207671170.1033861380093930.293160768313315
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) unknown
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -0.20028 0.14875
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
0.997 0.968 1.064 1.088 1.228
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

Drugbank ID Drug Name Drug Status Pharmacological Action Drug Action
DB02900 alpha-D-mannose 6-phosphate experimental unknown unknown
DB01277 Mecasermin approved, investigational unknown unknown

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
1E6F X-ray 1.7Å A/B=1508-1650.
1GP0 X-ray 1.4Å A=1508-1650.
1GP3 X-ray 1.9Å A=1508-1650.
1GQB X-ray 1.8Å A/B=1508-1650.
1JPL X-ray 2.4Å E/F/G/H=2480-2491.
1JWG X-ray 2.0Å C/D=2479-2491.
1LF8 X-ray 2.3Å E/F/G/H=2480-2491.
2CNJ NMR - D=1508-1650.
2L29 NMR - A=1508-1647.
2L2A NMR - A=1508-1647.
2M68 NMR - A=1508-1647.
2M6T NMR - A=1508-1647.
2V5N X-ray 3.2Å A=1508-1799.
2V5O X-ray 2.9Å A=1508-2128.
2V5P X-ray 4.1Å A/B=1508-1992.
5IEI X-ray 2.8Å A=1508-1647.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
capsid co-localizes with 20889566

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04142 Lysosome - Homo sapiens (human)
hsa04144 Endocytosis - Homo sapiens (human)