Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0005304
UniProt IDP05362
Primary gene name(s)ICAM1
Synonym gene name(s)unknown
Protein nameIntercellular adhesion molecule 1
Protein functionICAM proteins are ligands for the leukocyte adhesion protein LFA-1, integrin alpha-L/beta-2. During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. {ECO:0000269|PubMed:11173916, ECO:0000269|PubMed:17875742}.; FUNCTION:, Microbial infection Acts as a receptor for major receptor group rhinovirus A-B capsid proteins, PubMed:1968231, PubMed:2538243. Acts as a receptor for Coxsackievirus A21 capsid proteins, PubMed:11160747, PubMed:16004874, PubMed:9539703. Upon Kaposi's sarcoma-associated herpesvirus/HHV-8 infection, is degraded by viral E3 ubiquitin ligase MIR2, presumably to prevent lysis of infected cells by cytotoxic T-lymphocytes and NK cell, PubMed:11413168. {ECO:0000269|PubMed:11160747, ECO:0000269|PubMed:11413168, ECO:0000269|PubMed:16004874, ECO:0000269|PubMed:1968231, ECO:0000269|PubMed:2538243, ECO:0000269|PubMed:9539703}.
Subcellular locationMembrane;
Single-pass type I membrane protein.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P05362
Gene Ontology
(Biological Process)
Complete annatation
acute inflammatory response to antigenic stimulus [GO:0002438];
adhesion of symbiont to host [GO:0044406];
cell adhesion [GO:0007155];
cell adhesion mediated by integrin [GO:0033627];
cell aging [GO:0007569];
cellular response to alkaloid [GO:0071312];
cellular response to glucose stimulus [GO:0071333];
cellular response to hypoxia [GO:0071456];
cellular response to interleukin-1 [GO:0071347];
cellular response to lipopolysaccharide [GO:0071222];
cellular response to nutrient levels [GO:0031669];
cellular response to tumor necrosis factor [GO:0071356];
establishment of endothelial barrier [GO:0061028];
establishment of Sertoli cell barrier [GO:0097368];
extracellular matrix organization [GO:0030198];
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157];
interferon-gamma-mediated signaling pathway [GO:0060333];
leukocyte cell-cell adhesion [GO:0007159];
leukocyte migration [GO:0050900];
membrane to membrane docking [GO:0022614];
negative regulation of calcium ion transport [GO:0051926];
negative regulation of endothelial cell apoptotic process [GO:2000352];
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042];
ovarian follicle development [GO:0001541];
positive regulation of actin filament polymerization [GO:0030838];
positive regulation of cellular extravasation [GO:0002693];
positive regulation of ERK1 and ERK2 cascade [GO:0070374];
positive regulation of GTPase activity [GO:0043547];
positive regulation of NF-kappaB transcription factor activity [GO:0051092];
positive regulation of nitric oxide biosynthetic process [GO:0045429];
positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731];
positive regulation of vasoconstriction [GO:0045907];
receptor-mediated virion attachment to host cell [GO:0046813];
regulation of cell adhesion [GO:0030155];
regulation of cell shape [GO:0008360];
regulation of immune response [GO:0050776];
regulation of leukocyte mediated cytotoxicity [GO:0001910];
regulation of ruffle assembly [GO:1900027];
response to amino acid [GO:0043200];
response to amphetamine [GO:0001975];
response to copper ion [GO:0046688];
response to drug [GO:0042493];
response to ethanol [GO:0045471];
response to gonadotropin [GO:0034698];
response to ionizing radiation [GO:0010212];
response to organic cyclic compound [GO:0014070];
response to sulfur dioxide [GO:0010477];
sensory perception of sound [GO:0007605];
T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell [GO:0002291];
T cell antigen processing and presentation [GO:0002457]
Gene Ontology
(Molecular Function)
Complete annatation
integrin binding [GO:0005178];
receptor activity [GO:0004872];
transmembrane signaling receptor activity [GO:0004888];
virus receptor activity [GO:0001618]
Gene Ontology
(Cellular Component)
Complete annatation
cell surface [GO:0009986];
external side of plasma membrane [GO:0009897];
extracellular exosome [GO:0070062];
extracellular space [GO:0005615];
focal adhesion [GO:0005925];
immunological synapse [GO:0001772];
integral component of plasma membrane [GO:0005887];
membrane [GO:0016020];
membrane raft [GO:0045121];
plasma membrane [GO:0005886]
Protein-protein interaction109610
Phylogenetic treeP05362
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD33.586461929620800
AZA vs. DISU0.3800514825160970.1424940893867280.718588431683073
AZA vs. IL70.1754187647889490.3835580181997230.999311006273513
AZA vs. SAHA-0.08829392431607360.7260119080315090.923626775006399
DISU vs. CD3-3.219630639952924.44089209850063e-162.71020273250196e-14
DISU vs. IL7-0.2149629599921630.4030555035059820.764226430756235
DISU vs. SAHA-0.4652003644418780.117135320755970.439578291611858
DMSO vs. AZA0.05259628376090770.7685370125637861
DMSO vs. CD3-3.546674226120100
DMSO vs. DISU-0.3298590583454760.1863047862566050.701868631421702
DMSO vs. IL70.1302924977923660.4891504538146460.884322644198525
DMSO vs. SAHA-0.1449728619441870.5508487127761960.838941200974091
HIV vs. Mock in Activation0.3496896614586440.5747836084771240.999983755607037
HIV vs. Mock in Latency-0.002204269326512540.9897574077548760.999834320637052
IL7 vs. CD3-3.4064074916449600
SAHA vs. CD3-3.6975762798317900
SAHA vs. IL7-0.2649358015637850.290301339366590.537328387722492
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock 0.975 2.75E-09 2.21E-07
Infected vs. Bystander 1.103 2.59E-10 1.81E-08
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) unknown
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.360222 0.00639837
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
1.384 0.97 0.706 0.859 1.006
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

Drugbank ID Drug Name Drug Status Pharmacological Action Drug Action
DB00108 Natalizumab approved, investigational unknown unknown
DB08818 Hyaluronic acid approved, vet_approved yes unknown

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
1D3E EM 28.0Å I=28-212.
1D3I EM 26.0Å I=28-212.
1D3L X-ray 3.2Å A=28-212.
1IAM X-ray 2.1Å A=28-212.
1IC1 X-ray 3.0Å A/B=28-217.
1IJ4 Model - I=44-109.
1MQ8 X-ray 3.3Å A/C=28-318.
1P53 X-ray 3.0Å A/B=212-477.
1Z7Z EM 8.0Å I=28-477.
2OZ4 X-ray 2.7Å A=213-477.
3TCX X-ray 3.6Å A/C/E/G/I/K/M/O/Q/S/U/W/Y/a=29-112.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Envelope surface glycoprotein gp120 induces rearrangement of 21850260
Envelope surface glycoprotein gp120 interacts with 15183063
matrix upregulates 22558273
Pr55(Gag) co-localizes with 7794538
Nef stimulates 24204260
Tat upregulates 18160848
matrix incorporates 25320314
Pr55(Gag) interacts with 15479832
Envelope surface glycoprotein gp160; precursor interacts with 7917519
matrix interacts with 25320314
reverse transcriptase p51 subunit interacts with 25320329
Envelope surface glycoprotein gp120 upregulates 11517385
Envelope surface glycoprotein gp120 regulated by 18632854
Pr55(Gag) incorporates 25320314
Nef interacts with 8086129
HIV-1 virus replication enhanced by expression of human gene 25985398
capsid interacts with 24663101
Tat interacts with 8568270
Pr55(Gag) upregulates 18945465
Nef co-localizes with 19912576
reverse transcriptase interacts with 25320329
Nef induces release of 12853962
matrix co-localizes with 7794538
Envelope surface glycoprotein gp120 incorporates 9865497
Vpu downregulates 25620704
Envelope surface glycoprotein gp120 activates 20083573
Nef upregulates 20056088
Envelope transmembrane glycoprotein gp41 upregulates 21668410

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04064 NF-kappa B signaling pathway - Homo sapiens (human)
hsa04514 Cell adhesion molecules (CAMs) - Homo sapiens (human)
hsa04650 Natural killer cell mediated cytotoxicity - Homo sapiens (human)
hsa04668 TNF signaling pathway - Homo sapiens (human)
hsa04670 Leukocyte transendothelial migration - Homo sapiens (human)
hsa04933 AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)
hsa05143 African trypanosomiasis - Homo sapiens (human)
hsa05144 Malaria - Homo sapiens (human)
hsa05150 Staphylococcus aureus infection - Homo sapiens (human)
hsa05164 Influenza A - Homo sapiens (human)
hsa05166 HTLV-I infection - Homo sapiens (human)
hsa05169 Epstein-Barr virus infection - Homo sapiens (human)
hsa05323 Rheumatoid arthritis - Homo sapiens (human)
hsa05416 Viral myocarditis - Homo sapiens (human)