Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0005293
UniProt IDP04792
Primary gene name(s)HSPB1
Synonym gene name(s)HSP27, HSP28
Protein nameHeat shock protein beta-1
Protein functionInvolved in stress resistance and actin organization.
Subcellular locationCytoplasm. Nucleus. Cytoplasm, cytoskeleton, spindle. Note=Cytoplasmic in interphase cells. Colocalizes with mitotic spindles in mitotic cells. Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P04792
Gene Ontology
(Biological Process)
Complete annatation
cellular response to vascular endothelial growth factor stimulus [GO:0035924];
intracellular signal transduction [GO:0035556];
movement of cell or subcellular component [GO:0006928];
negative regulation of apoptotic process [GO:0043066];
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902176];
negative regulation of protein kinase activity [GO:0006469];
platelet aggregation [GO:0070527];
positive regulation of angiogenesis [GO:0045766];
positive regulation of blood vessel endothelial cell migration [GO:0043536];
positive regulation of endothelial cell chemotaxis [GO:2001028];
positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway [GO:0038033];
positive regulation of interleukin-1 beta production [GO:0032731];
positive regulation of tumor necrosis factor biosynthetic process [GO:0042535];
regulation of autophagy [GO:0010506];
regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043122];
regulation of mRNA stability [GO:0043488];
regulation of translational initiation [GO:0006446];
response to unfolded protein [GO:0006986];
response to virus [GO:0009615];
retina homeostasis [GO:0001895];
vascular endothelial growth factor receptor signaling pathway [GO:0048010]
Gene Ontology
(Molecular Function)
Complete annatation
identical protein binding [GO:0042802];
poly(A RNA binding [GO:0044822];
protein kinase binding [GO:0019901];
protein kinase C binding [GO:0005080];
protein kinase C inhibitor activity [GO:0008426];
ubiquitin binding [GO:0043130]
Gene Ontology
(Cellular Component)
Complete annatation
cytoplasm [GO:0005737];
cytoskeleton [GO:0005856];
cytosol [GO:0005829];
extracellular exosome [GO:0070062];
extracellular space [GO:0005615];
focal adhesion [GO:0005925];
nucleus [GO:0005634];
plasma membrane [GO:0005886];
proteasome complex [GO:0000502];
spindle [GO:0005819];
Z disc [GO:0030018]
Protein-protein interaction109547
Phylogenetic treeP04792
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD30.7828349151988220.01786273170776310.0424313778249654
AZA vs. DISU-0.3082144942304770.2310540975961620.818063439936931
AZA vs. IL7-0.1319758426929540.5016756076990960.999311006273513
AZA vs. SAHA0.09967662934350930.6955430728517740.913853316459464
DISU vs. CD3-1.103080496642280.002839759535578130.0101030293224699
DISU vs. IL70.1664795268318320.5165256646094630.835624786176853
DISU vs. SAHA0.4093927565656630.2289109221539970.606474310802518
DMSO vs. AZA-0.1763517077001250.3070715862721391
DMSO vs. CD3-0.971215044404240.002703304100634910.00811907421771628
DMSO vs. DISU0.1295648215044330.6026250309161690.939289650701039
DMSO vs. IL70.05212673954798790.7770660773769080.954134798137059
DMSO vs. SAHA0.2702627057302260.2890876600008580.640806019101769
HIV vs. Mock in Activation0.3231886963208820.6116946925951910.999983755607037
HIV vs. Mock in Latency-0.6120361649103540.005038476289989770.20694820598176
IL7 vs. CD3-0.9084463228475340.005176861412503730.0172596399183076
SAHA vs. CD3-0.7076061772926990.04835919621154690.0962966552468304
SAHA vs. IL70.228990118289650.3759067144812190.625845628136488
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) unknown
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -1.04818 0.000305467
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
1.015 0.802 0.797 1.147 0.4
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
201841_s_at 1.85 No downregulated in CD8+ cells

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

Drugbank ID Drug Name Drug Status Pharmacological Action Drug Action
DB06094 OGX-427 investigational unknown unknown

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
2N3J NMR - A/B=80-176.
3Q9P X-ray 2.0Å A=90-171.
3Q9Q X-ray 2.2Å A/B=90-171.
4MJH X-ray 2.6Å A/C=84-176# B/D=179-186.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Vpr inhibited by 17622316
Vpr competes with 17622316

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04010 MAPK signaling pathway - Homo sapiens (human)
hsa04370 VEGF signaling pathway - Homo sapiens (human)
hsa05146 Amoebiasis - Homo sapiens (human)
hsa05169 Epstein-Barr virus infection - Homo sapiens (human)