Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0004626
UniProt IDO14641
Primary gene name(s)DVL2
Synonym gene name(s)unknown
Protein nameSegment polarity protein dishevelled homolog DVL-2
Protein functionPlays a role in the signal transduction pathways mediated by multiple Wnt genes. Participates both in canonical and non-canonical Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. {ECO:0000250|UniProtKB:Q60838, ECO:0000269|PubMed:19252499}.
Subcellular locationCell membrane {ECO:0000250|UniProtKB:Q60838};
Peripheral membrane protein {ECO:0000250|UniProtKB:Q60838};
Cytoplasmic side {ECO:0000250|UniProtKB:Q60838}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q60838}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:Q60838}. Nucleus {ECO:0000269|PubMed:25805136}. Note=Localizes at the cell membrane upon interaction with frizzled family members and promotes their internalization. Localizes to cytoplasmic puncta, By similarity. Interaction with FOXK1 and FOXK2 induces nuclear translocation, PubMed:25805136. {ECO:0000250|UniProtKB:Q60838, ECO:0000269|PubMed:25805136}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: O14641
Gene Ontology
(Biological Process)
Complete annatation
beta-catenin destruction complex disassembly [GO:1904886];
canonical Wnt signaling pathway [GO:0060070];
canonical Wnt signaling pathway involved in regulation of cell proliferation [GO:0044340];
cellular protein localization [GO:0034613];
cochlea morphogenesis [GO:0090103];
convergent extension involved in neural plate elongation [GO:0022007];
heart development [GO:0007507];
hippo signaling [GO:0035329];
negative regulation of canonical Wnt signaling pathway [GO:0090090];
neural tube closure [GO:0001843];
non-canonical Wnt signaling pathway [GO:0035567];
outflow tract morphogenesis [GO:0003151];
planar cell polarity pathway involved in neural tube closure [GO:0090179];
positive regulation of canonical Wnt signaling pathway [GO:0090263];
positive regulation of GTPase activity [GO:0043547];
positive regulation of JUN kinase activity [GO:0043507];
positive regulation of protein phosphorylation [GO:0001934];
positive regulation of protein tyrosine kinase activity [GO:0061098];
positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091];
positive regulation of transcription, DNA-templated [GO:0045893];
protein oligomerization [GO:0051259];
segment specification [GO:0007379];
transcription from RNA polymerase II promoter [GO:0006366];
Wnt signaling pathway [GO:0016055];
Wnt signaling pathway, planar cell polarity pathway [GO:0060071]
Gene Ontology
(Molecular Function)
Complete annatation
frizzled binding [GO:0005109];
identical protein binding [GO:0042802]
Gene Ontology
(Cellular Component)
Complete annatation
apical part of cell [GO:0045177];
clathrin-coated endocytic vesicle [GO:0045334];
cytoplasm [GO:0005737];
cytoplasmic vesicle [GO:0031410];
cytosol [GO:0005829];
nucleus [GO:0005634];
plasma membrane [GO:0005886]
Protein-protein interaction108189
Phylogenetic treeO14641
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD30.3544502053953490.2799093874794960.395573772910546
AZA vs. DISU0.216102195172060.3968872650327410.903045831411854
AZA vs. IL7-0.1162080977376440.5485393575362190.999311006273513
AZA vs. SAHA0.1921355466597280.4339347675152140.783065904819035
DISU vs. CD3-0.1509724169109090.6785670866864370.773496692733768
DISU vs. IL7-0.3418124656276990.1778916338472150.545729829110045
DISU vs. SAHA-0.02161193710148340.9418559095884420.986472910903827
DMSO vs. AZA0.08912334165084780.5981237581081221
DMSO vs. CD3-0.277897645558140.3853572537798580.499862840381742
DMSO vs. DISU-0.1290957635234670.5990838591747170.937521870059328
DMSO vs. IL7-0.1977858090346030.274908780914250.769860685669313
DMSO vs. SAHA0.09803584599758190.6796777371880880.899841584157544
HIV vs. Mock in Activation0.1100307057497410.8597487410644770.999983755607037
HIV vs. Mock in Latency0.07545999021660630.6510275404235590.999834320637052
IL7 vs. CD3-0.4649860991463160.1489514270163970.257677592036974
SAHA vs. CD3-0.1858495358230080.6001884585682060.697742811897158
SAHA vs. IL70.3059960295203480.2130463184634090.449847346199388
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) unknown
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -0.00109875 0.995936
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
0.884 1.155 1.069 1.301 1.223
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
2REY X-ray 1.5Å A=261-355.
3CBX X-ray 1.7Å A/B=264-354.
3CBY X-ray 1.5Å A/B=264-354.
3CBZ X-ray 1.3Å A=264-354.
3CC0 X-ray 1.7Å A/B/C=264-354.
4WIP X-ray 2.6Å A/B/C=12-106.
5LNP X-ray 1.9Å A/B/C/D=416-510.
5SUY X-ray 1.8Å A/B/C/D=416-510.
5SUZ X-ray 1.8Å A/B=416-509.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04150 mTOR signaling pathway - Homo sapiens (human)
hsa04310 Wnt signaling pathway - Homo sapiens (human)
hsa04330 Notch signaling pathway - Homo sapiens (human)
hsa04390 Hippo signaling pathway - Homo sapiens (human)
hsa04550 Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)
hsa04916 Melanogenesis - Homo sapiens (human)
hsa05166 HTLV-I infection - Homo sapiens (human)
hsa05200 Pathways in cancer - Homo sapiens (human)
hsa05217 Basal cell carcinoma - Homo sapiens (human)
hsa05224 Breast cancer - Homo sapiens (human)