Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0004414
UniProt IDP67870
Primary gene name(s)CSNK2B
Synonym gene name(s)CK2N, G5A
Protein nameCasein kinase II subunit beta
Protein functionParticipates in Wnt signaling, By similarity. Plays a complex role in regulating the basal catalytic activity of the alpha subunit. {ECO:0000250, ECO:0000269|PubMed:11239457, ECO:0000269|PubMed:16818610}.
Subcellular locationunknown
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P67870
Gene Ontology
(Biological Process)
Complete annatation
adiponectin-activated signaling pathway [GO:0033211];
cellular protein complex assembly [GO:0043623];
endothelial tube morphogenesis [GO:0061154];
negative regulation of blood vessel endothelial cell migration [GO:0043537];
negative regulation of cell proliferation [GO:0008285];
positive regulation of activin receptor signaling pathway [GO:0032927];
positive regulation of pathway-restricted SMAD protein phosphorylation [GO:0010862];
protein folding [GO:0006457];
protein phosphorylation [GO:0006468];
regulation of DNA binding [GO:0051101];
regulation of protein serine/threonine phosphatase activity [GO:0080163];
regulation of signal transduction by p53 class mediator [GO:1901796];
signal transduction [GO:0007165];
Wnt signaling pathway [GO:0016055]
Gene Ontology
(Molecular Function)
Complete annatation
chromatin binding [GO:0003682];
identical protein binding [GO:0042802];
metal ion binding [GO:0046872];
protein domain specific binding [GO:0019904];
protein kinase regulator activity [GO:0019887];
receptor binding [GO:0005102];
transcription factor binding [GO:0008134]
Gene Ontology
(Cellular Component)
Complete annatation
cytoplasm [GO:0005737];
cytosol [GO:0005829];
extracellular exosome [GO:0070062];
nucleoplasm [GO:0005654];
nucleus [GO:0005634];
protein kinase CK2 complex [GO:0005956]
Protein-protein interaction107843
Phylogenetic treeP67870
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD30.8511731918437620.009981846595808140.0260377971429596
AZA vs. DISU0.1971387678452860.4365993154194790.917637769190354
AZA vs. IL70.007145634333624410.9704844422728520.999311006273513
AZA vs. SAHA0.1930827569506520.4306638002035590.780064560856667
DISU vs. CD3-0.666624902080360.06706463368442780.136679484549074
DISU vs. IL7-0.1992996815816210.4295098819428560.783991641237844
DISU vs. SAHA-0.001581631942167180.995691370592730.999572425883731
DMSO vs. AZA-0.05379038699261970.7496384390134041
DMSO vs. CD3-0.9172282395325710.004491756398534610.0125149454677129
DMSO vs. DISU-0.2529802950788980.3007417189447530.807887568985919
DMSO vs. IL70.06851577121191510.7044880217554180.939492969659275
DMSO vs. SAHA0.2419101987812290.3072355206931070.659593523129034
HIV vs. Mock in Activation-0.04089362605427190.9476519260461450.999983755607037
HIV vs. Mock in Latency-0.01315234296923770.936774067453430.999834320637052
IL7 vs. CD3-0.8378470944435110.00957904943934440.0287848907893218
SAHA vs. CD3-0.6815863495625310.05686103539120750.110160032648241
SAHA vs. IL70.1837252738812540.4538103036053050.691192938925571
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) unknown
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.0526521 0.867539
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
1.032 0.999 1.056 1.12 0.947
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
1DS5 X-ray 3.1Å E/F/G/H=181-203.
1JWH X-ray 3.1Å C/D=1-215.
1QF8 X-ray 1.7Å A/B=1-182.
3EED X-ray 2.8Å A/B=1-193.
4DGL X-ray 3.0Å A/B=1-215.
4MD7 X-ray 3.1Å A/B/C/D=1-215.
4MD8 X-ray 3.3Å A/B/C/D=1-215.
4MD9 X-ray 3.5Å A/B/C/D/I/J/N/O=1-215.
4NH1 X-ray 3.3Å C/D=1-215.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Rev interacts with 22174317
reverse transcriptase stimulated by 9654140
Rev binds 11827166
matrix phosphorylated by 9151826
Rev activates 9654140
reverse transcriptase phosphorylated by 9654140
retropepsin phosphorylated by 10964683
Rev phosphorylated by 10984616
Vpu phosphorylated by 12954211
Rev modulated by 7794916

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa03008 Ribosome biogenesis in eukaryotes - Homo sapiens (human)
hsa04064 NF-kappa B signaling pathway - Homo sapiens (human)
hsa04310 Wnt signaling pathway - Homo sapiens (human)
hsa04520 Adherens junction - Homo sapiens (human)
hsa05162 Measles - Homo sapiens (human)
hsa05168 Herpes simplex infection - Homo sapiens (human)
hsa05169 Epstein-Barr virus infection - Homo sapiens (human)